Binding Protein 2 (CUG) Antibody – Rabbit Polyclonal

RNA editing is an important mechanism for regulating genetic plasticity through the generation of alternative protein productsfrom a single structural gene. Substitutional RNA editing employsa variety of genetic mechanisms, the biochemical basis of whichhas been elucidated following the development of in vitro assaysthat recapitulate important elements of this process. There are two typesof substitutional RNA exist in mammals, namely A-to-I and C-to-URNA editing. The best-characterized example of C-to-U RNA editing involves the nuclear transcript encoding intestinal apolipoprotein B(apo B)). Apo B RNA editing changes a CAA to a UAA stop codon,generating a truncated protein, apoB48. The functional complex includes a minimal corecomposed of apobec-1 and ACF, that functionas an adaptor protein by binding both the deaminase and the RNAsubstrate. The RNA binding proteins also include CUGBP2 which along with Apobec-1 binds to the consensus binding sequence UUUN (A/U) U, present in c-myc, VEGF and Cyclooxygenase-2 (COX2).

• Shrikant Anant et al (2001) JBC, Vol. 276, No: 50, 47338-47351; Duanxiang Li et al (2001) Genomics 74, 396-401; Lu X et al (1999) Hum. Mol. Genet. 8 (1), 53-60.

Small volumes of anti-CUG-Binding Protein 2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS617933 is an antibody targeting CUG-Binding Protein 2. Also known as Anti - CUG-Binding Protein 2 (NAPOR). Reactive in Human. Host: Rabbit
Source: Human.