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Eukaryotic Translation Initiation Factor 5a2 (EIF5A2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS617935

Eukaryotic translation initiation factor 5A (eIF5A) is an essential protein tightly linked to cellular polyamine homeostasis. EIF5A2, a novel phylogenetically conserved gene for eIF5A islocalized in an area of the genome often noted for chromosomal… More details

$625 / 0.1 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
Eukaryotic Translation Initiation Factor 5A2 (EIF5A2), Polyclonal Antibody
Full Product Name
Eukaryotic Translation Initiation Factor 5A2 (eIF 5A2, eIF5A2 Protein Synthesis Initiation Factor)
Product Gene Name
anti-EIF5A2 antibody
Product Synonym Names
Anti -Eukaryotic Translation Initiation Factor 5A2 (eIF 5A2, eIF5A2 Protein Synthesis Initiation Factor)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Reacts with the human EIF5 A2 protein. Cross-reactivity with human eIF5 A1 protein has been shown in endogenous samples. Species Crossreactivity: Human. Others not unknown.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
16,793 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (170606204..170626426, complement). Location: 3q26.2
OMIM
605782
3D Structure
ModBase 3D Structure for Q9GZV4
Immunogen
A synthetic peptide representing the C-terminus of the Human EIF5 A2 protein.

Product Categories/Family for anti-EIF5A2 antibody

Antibodies; Abs to Translation Initiation Factors
Applications Tested/Suitable for anti-EIF5A2 antibody
Western Blot (WB)
Application Notes for anti-EIF5A2 antibody
Suitable for use in Western Blot.

Other Notes

Small volumes of anti-EIF5A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EIF5A2 purchase

MBS617935 is an antibody targeting EIF5A2. Also known as Eukaryotic Translation Initiation Factor 5A2 (eIF 5A2, eIF5A2 Protein Synthesis Initiation Factor). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EIF5A2. It may not necessarily be applicable to this product.

NCBI GI #
119598907
NCBI GeneID
56648
UniProt Primary Accession #
Q9GZV4
UniProt Secondary Accession #
B2R4V5
UniProt Related Accession #
Q9GZV4
NCBI Official Full Name
eukaryotic translation initiation factor 5A2
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 5A2
NCBI Official Symbol
EIF5A2
NCBI Official Synonym Symbols
EIF-5A2; eIF5AII
UniProt Protein Name
Eukaryotic translation initiation factor 5A-2
UniProt Synonym Protein Names
Eukaryotic initiation factor 5A isoform 2
UniProt Gene Name
EIF5A2
UniProt Entry Name
IF5A2_HUMAN
NCBI Protein Information
eukaryotic translation initiation factor 5A-2; eIF-5A-2; OTTHUMP00000213742; OTTHUMP00000213744; OTTHUMP00000213745; eukaryotic initiation factor 5A

UniProt Comments for EIF5A2

EIF5A2: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Belongs to the eIF-5A family.

Chromosomal Location of Human Ortholog: 3q26.2

Cellular Component: endoplasmic reticulum membrane; nuclear pore; cytosol

Molecular Function: protein binding; ribosome binding; translation elongation factor activity

Biological Process: protein transport; cellular protein metabolic process; translational frameshifting; mRNA transport; positive regulation of cell proliferation; positive regulation of translational elongation; spermatogenesis; hypusine biosynthetic process from peptidyl-lysine; polyamine homeostasis; post-translational protein modification; positive regulation of translational termination
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Research Articles on EIF5A2

1. EIF5A2 plays an important role in hepatocellular carcinoma invasion and metastasis by inducing epithelial-mesenchymal transition, as well as stimulating cytoskeleton rearrangement through activation of RhoA and Rac1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-EIF5A2 antibody

 Reference Product  PubMed Publications
 DHPS antibody  >1 publications with EIF5A2 and DHPS

Pathways associated with anti-EIF5A2 antibody

 Products by Pathway  Pathway Diagram
 Hypusine Synthesis From EIF5A-lysine Pathway antibodies  Hypusine Synthesis From EIF5A-lysine Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Post-translational Modification: Gamma Carboxylation And Hypusine Formation Pathway antibodies  Post-translational Modification: Gamma Carboxylation And Hypusine Formation Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram

Diseases associated with anti-EIF5A2 antibody

 Disease Name  Pubmed Publications
 Carcinoma, Squamous Cell Antibodies  >1 publications with EIF5A2 and Carcinoma, Squamous Cell
 Liver Neoplasms, Experimental Antibodies  >1 publications with EIF5A2 and Liver Neoplasms, Experimental

Organs/Tissues associated with anti-EIF5A2 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >2 publications with EIF5A2 and Testis
 Brain Antibodies  >2 publications with EIF5A2 and Brain
 Embryonic Tissue Antibodies  >1 publications with EIF5A2 and Embryonic Tissue
 Stomach Antibodies  >1 publications with EIF5A2 and Stomach
 Lung Antibodies  >1 publications with EIF5A2 and Lung
 Pancreas Antibodies  >1 publications with EIF5A2 and Pancreas
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