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Melanin Concentrating Hormone Receptor 2 (MCHR2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS618018

The cyclic neuropeptide, Melanin-Concentrating Hormone (MCH), plays an important role in food intake and energy balance. MCH stimulates feeding, it is up regulated in obese mice and in fasting. Animals lacking MCH eat less and are lean. Most recently, a… More details

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Product Overview

Online Datasheet in PDF
Product Name
Melanin Concentrating Hormone Receptor 2 (MCHR2), Polyclonal Antibody
Full Product Name
Anti - Melanin Concentrating Hormone Receptor 2 (MCHR2)
Product Gene Name
anti-MCHR2 antibody
Product Synonym Names
Melanin Concentrating Hormone Receptor 2 (MCHR2)
Clonality
Polyclonal
Isotype
IgG
Host
Host: Rabbit
Source: Human
Species Reactivity
Human
Form/Format
Serum
Supplied as a liquid, neat serum, 40% glycerol.
Purity/Purification
Serum
Specificity
The human peptide sequence is 84% conserved in monkey MCHR2. No significant sequence homology is seen with other MCHR1 or other GPCR. Antibody crossreactivity in various species is not established. Control peptide, because of its low MW (<3kD), is not suitable for Western. It should be used in ELISA or antibody blocking experiments (use 5-10 ug of control peptide per 1 ug IgG or 1 ul of antiserum) to confirm antibody specificity.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
38,849 Da
Chromosome Location
Chromosome: 6; NC_000006.11 (100367786..100442114, complement). Location: 6q16
OMIM
606111
3D Structure
ModBase 3D Structure for Q969V1
Immunogen
A 19 amino acid peptide near the cytoplasmic C-terminus of human MCHR2 was synthesized, coupled to KLH

Product Categories/Family for anti-MCHR2 antibody

Abs to Receptors
Applications Tested/Suitable for anti-MCHR2 antibody
ELISA, Western Blot
Application Notes for anti-MCHR2 antibody
Suitable for use in ELISA, Western Blotting. Other applications not tested.
Dilution: Western Blot: 1:1000-1:5000 for neat serum (ECL).
ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well.
Optimal dilutions to be determined by the researcher.

Product References and Citations for anti-MCHR2 antibody

• 1. Chambers J et al (1999) nature 400, 261-265; Saito Y et al (1999) Nature 400, 265-269; Kolakowski LF et al (1996) FEBS Lett. 398, 253-259; Lakaye B et al (1998) BBA 1401, 216-220; (2). Hills J et al (2001) JBC 276, 20125-20129

Other Notes

Small volumes of anti-MCHR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MCHR2 purchase

MBS618018 is an antibody targeting MCHR2. Also known as Anti - Melanin Concentrating Hormone Receptor 2 (MCHR2). Reactive in Human. Host: Rabbit
Source: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for MCHR2. It may not necessarily be applicable to this product.

NCBI GI #
119220588
NCBI GeneID
84539
NCBI Accession #
NP_115892.2
UniProt Primary Accession #
Q969V1
UniProt Secondary Accession #
Q5VTV7; Q6Q377; Q9BXA8; B3KVW4; E1P5D7
UniProt Related Accession #
Q969V1
GenBank Nucleotide #
NM_032503.2
NCBI Official Full Name
melanin-concentrating hormone receptor 2
NCBI Official Synonym Full Names
melanin-concentrating hormone receptor 2
NCBI Official Symbol
MCHR2
NCBI Official Synonym Symbols
SLT; MCH2; MCH2R; GPR145; GPRv17; MCH-2R; MCH-R2; MCHR-2
UniProt Protein Name
Melanin-concentrating hormone receptor 2
UniProt Synonym Protein Names
G-protein coupled receptor 145; GPRv17; MCH-2R
Protein Family
Melanin-concentrating hormone receptor
UniProt Gene Name
MCHR2
UniProt Synonym Gene Names
GPR145; SLT
UniProt Entry Name
MCHR2_HUMAN
NCBI Protein Information
melanin-concentrating hormone receptor 2; MCH receptor 2; OTTHUMP00000016901; G protein-coupled receptor 145; G protein-coupled receptor slt; G-protein coupled receptor 145; melanin-concentrating hormone 2

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MCHR2 antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Organs/Tissues associated with anti-MCHR2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with MCHR2 and Brain
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