Napi-4 (Npt2a) Antibody – Rabbit Polyclonal

Inorganic phosphate (Pi) levels are hormonally regulated that affectsthe physiological activity of bone, kidney, and small intestine. Majorityof the Pi is absorbed in the small intestine and reabsorbed in theproximal tubules in the kidney. At least 4 groups of structurally andfuncationally related proteins are in involved in Pi transport: TypeI-related NaPi transporters designated NPT1, Npt1, and NaPi-1respectively in humans, mouse, and rabbit are expressed in the kidneyand liver. Its expression and activity are not regulated by Pi deprivationor parathyroid hormone (PTH) and its role in Pi-homeostasis is notclear. Type IIa-related cotransporters, designated NaPi-2 in rat, NaPi-3or NPT2 in humans, NaPi-4 in opposum, NaPi-5 in flounder vessel,NaPi-6 or Npt-2 in mouse, and NaPi-7 in rabbit, is the primary targetfor Pi regulation by dietary, hormonal, and tubular Pi reabsorption.Deletion of Npt2 gene produces severe Pi wasting. Type II transportersare expressed in kidney, brain, lung, bone and small intestine. Type IIb,designated as NaPi-IIB or NaPi-2b in rat/mouse, and NaPi-3b inhuman, is closely related isoform of the NaPi-2 family. It is expressedin small intestine and lung. Type III NaPi transporters, originallydescribed as a family of cell surface receptors for gibbon ape leukemiavirus (GALV) and murine amphotropic retrovirus (A-MuLv), share verylow (<20%) sequence homology with Type I and II proteins, and arefound in most tissues. Human homolog are now desganted as PiT1(also known as GALV receptors or GLVR1) and PiT2 (A-MuLVreceptors or GLVR2 or Ram1). Pit1 and Pit2 are ~62% related andpredicted to contain 10 TM domains that is in contrast with Type 1/2transporters (6-8 TM). The N and C-termini are predicted to becytoplasmic.

1. Magnin S et al (1993) PNAS 90, 5979. 2. Collins JF et al (1996) FASEB J 8, 862. 3. Hartman CM et al (1996) PNAS 93, 7409. 4. Murer H et al (2000) Physiolo.Rev. 80, 1373. 5. Werner A et al (2001) Am. J. Physiol. Integ. Comp. Physiol. 280, R301

Small volumes of anti-NaPi-4 (Npt2a) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS618069 is an antibody targeting NaPi-4 (Npt2a). Also known as Rabbit anti-Opossum NaPi-4, NT (Npt2a). Host: Rabbit
Source: Opossum.