Rabbit Anti-CYR61 Polyclonal Antibody – Cat# MBS618208

Detection of cleaved CYR61 in MDA-MB-231 cell lysate using MBS618208 Photo courtesy of Dr. Lupu's Lab, Northwestern University. Image by Dr. Ingrid Espinoza.

Cysteine-Rich, Angiogenic Inducer 61 (CYR61) Antibody – Rabbit Polyclonal

Name: CYR61 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS618208
Price: 710 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS618208

CYR61 is a cysteine-rich, heparin-binding, growth factor belonging to the CCN family of secreted regulatory proteins. It stimulates chondrogensis and angiogenesis, playing an important role in cartilage and bone formation, as well as tumor growth and… More details

$710 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cysteine-rich, Angiogenic Inducer 61 (CYR61), Polyclonal Antibody

Full Product Name

Cysteine-rich, Angiogenic Inducer 61 (CYR61)

Product Gene Name

anti-CYR61 antibody

Product Synonym Names

Anti -Cysteine-rich, Angiogenic Inducer 61 (CYR61)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in Tris-citrate/phosphate buffer, pH 7.5 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes human CYR61 protein. Species sequence homology: rat,100% and mouse, 96%.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

42,027 Da

Chromosome Location

Chromosome: 1; NC_000001.10 (86046444..86049650). Location: 1p22.3

OMIM

602369

3D Structure

ModBase 3D Structure for O00622

Immunogen

Synthetic peptide corresponding to the human CYR61 protein sequence (between residues 250-350). Cellular Localization: Secreted.

Positive Control

MDA-MB-231 breast cancer cell lysate

Product Categories/Family for anti-CYR61 antibody

Antibodies; Abs to Growth Factors; Cytokines

Applications Tested/Suitable for anti-CYR61 antibody

Western Blot (WB)

Application Notes for anti-CYR61 antibody

Suitable for use in Western Blot.
Dilution: Western Blot: 1:200 (ECL). Recognizes a band at ~37kD (processed form) and ~45kD (full-length form).

Other Notes

Small volumes of anti-CYR61 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CYR61 purchase

MBS618208 is an antibody targeting CYR61. Also known as Cysteine-rich, Angiogenic Inducer 61 (CYR61). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CYR61. It may not necessarily be applicable to this product.

NCBI GI #

119593604

NCBI GeneID

3491

UniProt Primary Accession #

O00622

UniProt Secondary Accession #

O14934; O43775; Q9BZL7

UniProt Related Accession #

O00622; O95694; Q53FA4; Q6FI18; Q9UID7

NCBI Official Full Name

cysteine-rich, angiogenic inducer, 61, isoform CRA_a

NCBI Official Synonym Full Names

cysteine-rich, angiogenic inducer, 61

NCBI Official Symbol

CYR61

NCBI Official Synonym Symbols

CCN1; GIG1; IGFBP10

UniProt Protein Name

Protein CYR61

UniProt Synonym Protein Names

CCN family member 1; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10; IGFBP-10; Protein GIG1

Protein Family

Protein

UniProt Gene Name

CYR61

UniProt Synonym Gene Names

CCN1; GIG1; IGFBP10

UniProt Entry Name

CYR61_HUMAN

NCBI Protein Information

protein CYR61; IBP-10; IGFBP-10; OTTHUMP00000012303; CCN family member 1; IGF-binding protein 10; cysteine-rich, anigogenic inducer, 61; cysteine-rich heparin-binding protein 61; insulin-like growth factor-binding protein 10

NCBI Summary for CYR61

CYR61 is a secreted, cysteine-rich, heparin-binding protein encoded by a growth factor-inducible immediate-early gene. Acting as an extracellular, matrix-associated signaling molecule, CYR61 promotes the adhesion of endothelial cells through interaction with integrin and augments growth factor-induced DNA synthesis in the same cell type.[supplied by OMIM]

UniProt Comments for CYR61

CYR61: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Belongs to the CCN family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p22.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix

Molecular Function: heparin binding; integrin binding; insulin-like growth factor binding; extracellular matrix binding

Biological Process: extracellular matrix organization and biogenesis; anatomical structure morphogenesis; positive regulation of caspase activity; chemotaxis; intussusceptive angiogenesis; osteoblast differentiation; cell proliferation; positive regulation of osteoblast differentiation; cell-cell signaling; positive regulation of protein kinase activity; positive regulation of osteoblast proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; regulation of cell growth; cell adhesion; positive regulation of BMP signaling pathway; negative regulation of apoptosis; positive regulation of cell migration

Research Articles on CYR61

1. Findings define the TAZ-TEAD-Cyr61/CTGF signaling pathway as an important modifier of the Taxol response in breast cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CYR61 antibody

Reference Product	PubMed Publications
ITGAV antibody	>1 publications with CYR61 and ITGAV

Pathways associated with anti-CYR61 antibody

Products by Pathway	Pathway Diagram
Hypertrophy Model Pathway antibodies	Hypertrophy Model Pathway Diagram
Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies	Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
RhoA Signaling Pathway antibodies	RhoA Signaling Pathway Diagram
Amb2 Integrin Signaling Pathway antibodies	Amb2 Integrin Signaling Pathway Diagram

Diseases associated with anti-CYR61 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>147 publications with CYR61 and Neoplasms
Carcinoma Antibodies	>60 publications with CYR61 and Carcinoma
Vascular Diseases Antibodies	>33 publications with CYR61 and Vascular Diseases
Inflammation Antibodies	>30 publications with CYR61 and Inflammation
Breast Neoplasms Antibodies	>30 publications with CYR61 and Breast Neoplasms
Adenocarcinoma Antibodies	>30 publications with CYR61 and Adenocarcinoma
Neoplasm Invasiveness Antibodies	>24 publications with CYR61 and Neoplasm Invasiveness
Fibrosis Antibodies	>24 publications with CYR61 and Fibrosis
Neuroectodermal Tumors Antibodies	>22 publications with CYR61 and Neuroectodermal Tumors
Neoplasm Metastasis Antibodies	>21 publications with CYR61 and Neoplasm Metastasis

Organs/Tissues associated with anti-CYR61 antibody

Organ/Tissue Name	Pubmed Publications
Connective Tissue Antibodies	>143 publications with CYR61 and Connective Tissue
Vascular Antibodies	>96 publications with CYR61 and Vascular
Muscle Antibodies	>58 publications with CYR61 and Muscle
Bone Antibodies	>51 publications with CYR61 and Bone
Embryonic Tissue Antibodies	>45 publications with CYR61 and Embryonic Tissue
Lung Antibodies	>30 publications with CYR61 and Lung
Brain Antibodies	>30 publications with CYR61 and Brain
Prostate Antibodies	>23 publications with CYR61 and Prostate
Kidney Antibodies	>21 publications with CYR61 and Kidney
Skin Antibodies	>19 publications with CYR61 and Skin