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c-ABL Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS618210

Bcr-Abl hybrid gene product is a 210kD protein known to be assembled in the K562 (human chronic myelogenous leukemia) cell line. The c-Abl proto-oncogene encodes a nonreceptor type protein tyrosine kinase that is ubiquitously expressed and highly conserved in… More details

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Product Overview

Online Datasheet in PDF
Product Name
c-Abl, Polyclonal Antibody
Full Product Name
Anti - c-Abl (ABL1, v-abl, Abelson Murine Leukemia Viral Oncogene Homolog 1, ABL, c-ABL, JTK7, p150, Proto-Oncogene Tyrosine-Protein Kanase ABL1, v-abl)
Product Gene Name
anti-c-Abl antibody
Product Synonym Names
c-Abl (ABL1, v-abl, Abelson Murine Leukemia Viral Oncogene Homolog 1, ABL, c-ABL, JTK7, p150, Proto-Oncogene Tyrosine-Protein Kanase ABL1, v-abl)
Clonality
Polyclonal
Isotype
IgG
Host
Host: Rabbit
Source: Human
Species Reactivity
Drosophila, Human, Mouse, Rat
Form/Format
Affinity Purified
Supplied as liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. No preservative added.
Purity/Purification
Purified by Protein A affinity chromatography.
Specificity
Detects overexpressed levels of Abl proteins. The antibody detects Abl proteins immunoprecipitated from various cell lines. It does not crossreact with other related tyrosine kinase family members. Species Crossreactivity: Human, mouse and rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
13,150 Da
Chromosome Location
chromosome: 9; Location: 9q34.1
3D Structure
ModBase 3D Structure for Q13915
Immunogen
Synthetic peptide (KLH coupled) derived from the C-terminus of human c-Abl.

Product Categories/Family for anti-c-Abl antibody

Abs to Apoptosis
Applications Tested/Suitable for anti-c-Abl antibody
ELISA, Western Blot, Immunoprecipitation, Immunofluorescence
Application Notes for anti-c-Abl antibody
Suitable for use in ELISA, Western Blot, Immunoprecipitation and Immunofluoroescence. Other applications not tested.
Dilution: Western Blot: 1:1000, incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight. Recognizes bands at 135kD (c-Abl) (210kD (Bcr-Abl)).
Immunoprecipitation: 1:100
Immunofluorescence: 1:25
Optimal dilutions to be determined by the researcher.

Western Blot (WB) of anti-c-Abl antibody

Western blot analysis of cell lysates from various cell lines, using MBS618210.
Rabbit Anti-c-ABL Polyclonal Antibody – Cat# MBS618210

Immunofluorescence (IF) of anti-c-Abl antibody

Confocal immunofluorescent analysis of HT-29 cells labeled with MBS618210 (green). Blue pseudocolor = DRAQ5™ (fluorescent DNA dye).
Rabbit Anti-c-ABL Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS618210

Immunohistochemistry (IHC) of anti-c-Abl antibody

Immunohistochemical staining of c-Abl in paraffin-embedded human breast carcinoma showing cytoplasmic localization, using c-Abl Antibody.
Rabbit Anti-c-ABL Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS618210

Product References and Citations for anti-c-Abl antibody

• 1. Wang, J.Y. (2000) Oncogene 19, 5643-5650.
• 2. Van Etten, R.A. (1999) Trends Cell. Biol. 9, 179-182.3. Danial, N.N. and Rothman, P. (2000) Oncogene 19, 2523-2531.
• 4. Shaul, Y. (2000) Cell Death Differ. 7, 10-16.
• 5. Brasher, B.B. and Van Etten, R.A. (2000) J. Biol. Chem. 275, 35631-35637.
• 6. Pluk, H. et al. (2002) Cell 108, 247-259.

Other Notes

Small volumes of anti-c-Abl antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for c-Abl purchase

MBS618210 is an antibody targeting c-Abl. Also known as Anti - c-Abl (ABL1, v-abl, Abelson Murine Leukemia Viral Oncogene Homolog 1, ABL, c-ABL, JTK7, p150, Proto-Oncogene Tyrosine-Protein Kanase ABL1, v-abl). Reactive in Drosophila, Human, Mouse, Rat. Host: Rabbit
Source: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for c-Abl. It may not necessarily be applicable to this product.

NCBI GI #
179750
NCBI GeneID
25
UniProt Primary Accession #
Q13915
UniProt Related Accession #
P00519; Q13688; Q13689; Q13690; Q13691; Q13848; Q13914; Q13915; Q14020; Q3B836
NCBI Official Full Name
c-abl
NCBI Official Synonym Full Names
c-abl oncogene 1, non-receptor tyrosine kinase
NCBI Official Symbol
ABL1
NCBI Official Synonym Symbols
ABL; JTK7; p150; c-ABL; v-abl; bcr/abl; ABL1
UniProt Protein Name
C-abl
Protein Family
Probable protein
UniProt Gene Name
ABL1
UniProt Entry Name
Q13915_HUMAN
NCBI Protein Information
tyrosine-protein kinase ABL1; proto-oncogene c-Abl; bcr/c-abl oncogene protein; c-abl oncogene 1, receptor tyrosine kinase; proto-oncogene tyrosine-protein kinase ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-c-Abl antibody

 Reference Product  PubMed Publications
 BCR antibody  >440 publications with c-Abl and BCR
 JAK2 antibody  >59 publications with c-Abl and JAK2
 SRC antibody  >32 publications with c-Abl and SRC
 ABL2 antibody  >16 publications with c-Abl and ABL2
 KIT antibody  >13 publications with c-Abl and KIT
 ABI1 antibody  >7 publications with c-Abl and ABI1
 JAK1 antibody  >7 publications with c-Abl and JAK1
 CBL antibody  >7 publications with c-Abl and CBL
 CRKL antibody  >6 publications with c-Abl and CRKL
 CD19 antibody  >6 publications with c-Abl and CD19

Pathways associated with anti-c-Abl antibody

 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CDO In Myogenesis Pathway antibodies  CDO In Myogenesis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram

Diseases associated with anti-c-Abl antibody

 Disease Name  Pubmed Publications
 Leukemia Antibodies  >453 publications with c-Abl and Leukemia
 Neoplasms Antibodies  >426 publications with c-Abl and Neoplasms
 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies  >225 publications with c-Abl and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
 Precursor Cell Lymphoblastic Leukemia-Lymphoma Antibodies  >95 publications with c-Abl and Precursor Cell Lymphoblastic Leukemia-Lymphoma
 Leukemia, Myeloid, Acute Antibodies  >72 publications with c-Abl and Leukemia, Myeloid, Acute
 Cell Transformation, Neoplastic Antibodies  >43 publications with c-Abl and Cell Transformation, Neoplastic
 Anemia Antibodies  >15 publications with c-Abl and Anemia
 Drug Toxicity Antibodies  >12 publications with c-Abl and Drug Toxicity
 Neoplasms, Experimental Antibodies  >11 publications with c-Abl and Neoplasms, Experimental
 Bone Diseases Antibodies  >9 publications with c-Abl and Bone Diseases

Organs/Tissues associated with anti-c-Abl antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >99 publications with c-Abl and Blood
 Bone Antibodies  >59 publications with c-Abl and Bone
 Bone Marrow Antibodies  >55 publications with c-Abl and Bone Marrow
 Prostate Antibodies  >4 publications with c-Abl and Prostate
 Spleen Antibodies  >4 publications with c-Abl and Spleen
 Muscle Antibodies  >3 publications with c-Abl and Muscle
 Lymph Node Antibodies  >3 publications with c-Abl and Lymph Node
 Lymph Antibodies  >3 publications with c-Abl and Lymph
 Brain Antibodies  >3 publications with c-Abl and Brain
 Heart Antibodies  >2 publications with c-Abl and Heart
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