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Eukaryotic Translation Initiation Factor 4h (EIF4H) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS618246

A variety of factors contribute to the initiation of translation. Eukaryotic initiation factor 4H (eIF4H) was purified to near homogeneity from rabbit reticulocyte lysate and shown to stimulate translation in an assay deficient in eIF4F and eIF4B (1). eIF4H… More details

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Product Overview

Online Datasheet in PDF
Product Name
Eukaryotic Translation Initiation Factor 4H (Eif4h), Polyclonal Antibody
Full Product Name
Eukaryotic Translation Initiation Factor 4H (eIF4H)
Product Gene Name
anti-Eif4h antibody
Product Synonym Names
Anti -Eukaryotic Translation Initiation Factor 4H (eIF4H)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Monkey, Mouse, Rat
Form/Format
Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol.
Purity/Purification
Purified by protein A and peptide affinity chromatography.
Specificity
Detects endogenous levels of total eIF4H protein (both long and short isoforms).
Preparation and Storage
For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
27,324 Da
Chromosome Location
Chromosome: 12; NC_005111.2 (23148332..23164980). Location: 12q12
3D Structure
ModBase 3D Structure for Q5XI72
Immunogen
Synthetic peptide (KLH-coupled) derived from a sequence of human eIF4H.

Product Categories/Family for anti-Eif4h antibody

Antibodies; Abs to Translation Initiation Factors
Applications Tested/Suitable for anti-Eif4h antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-Eif4h antibody
Suitable for use in Immunofluorescence and Western Blot.
Dilution: Western blotting: 1:1000
Immunofluorescence: 1:100

Western Blot (WB) of anti-Eif4h antibody

Western blot analysis of extracts from various cell types using MBS618246.
Rabbit Anti-EIF4H Polyclonal Antibody – Cat# MBS618246

Immunofluorescence (IF) of anti-Eif4h antibody

Confocal immunofluorescent analysis of PANC-1 cells using eIF4H Antibody (green). Actin filaments have been labeled with Alexa Fluor® 555 phalloidin (red). Blue pseudocolor = DRAQ5™ (fluorescent DNA dye).
Rabbit Anti-EIF4H Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS618246

Other Notes

Small volumes of anti-Eif4h antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Eif4h purchase

MBS618246 is an antibody targeting Eif4h. Also known as Eukaryotic Translation Initiation Factor 4H (eIF4H). Reactive in Human, Monkey, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Eif4h. It may not necessarily be applicable to this product.

NCBI GI #
55741853
NCBI GeneID
288599
NCBI Accession #
NP_001006958.1
UniProt Primary Accession #
Q5XI72
UniProt Related Accession #
Q5XI72
GenBank Nucleotide #
NM_001006957.1
NCBI Official Full Name
eukaryotic translation initiation factor 4H
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 4H
NCBI Official Symbol
Eif4h
NCBI Official Synonym Symbols
Wbscr1; MGC94887
UniProt Protein Name
Eukaryotic translation initiation factor 4H
UniProt Synonym Protein Names
Williams-Beuren syndrome chromosomal region 1 protein homolog
Protein Family
Eukaryotic translation initiation factor
UniProt Gene Name
Eif4h
UniProt Synonym Gene Names
Wbscr1
UniProt Entry Name
IF4H_RAT
NCBI Protein Information
eukaryotic translation initiation factor 4H; eIF-4H; Williams-Beuren syndrome chromosome region 1 homolog; williams-Beuren syndrome chromosomal region 1 protein homolog

UniProt Comments for Eif4h

EIF4H: eukaryotic translation initiation factor 4H stimulates protein translation. May stimulate the activities of EIF4A, EIF4B and EIF4F during the steps involving mRNA binding and utilization in the initiation of protein biosynthesis. Binds mRNA. Two alternatively spliced isoforms have been described. The short isoform is the predominant isoform and is expressed alone in liver and skeletal muscle. Both isoforms are expressed in fibroblast, spleen, testis and bone marrow. Levels are high in lung and pancreas and low in heart, frontal cortex and kidney.

Protein type: RNA-binding; Translation initiation; Translation

Cellular Component: membrane; perinuclear region of cytoplasm

Molecular Function: translation initiation factor activity; nucleotide binding

Biological Process: developmental growth; sexual reproduction; translational initiation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Eif4h antibody

 Products by Pathway  Pathway Diagram
 Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies  Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 Eukaryotic Translation Initiation Pathway antibodies  Eukaryotic Translation Initiation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Translation Pathway antibodies  Translation Pathway Diagram
 Translation Factors Pathway antibodies  Translation Factors Pathway Diagram

Diseases associated with anti-Eif4h antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with Eif4h and Neoplasms
 Colorectal Neoplasms Antibodies  >1 publications with Eif4h and Colorectal Neoplasms
 Breast Neoplasms Antibodies  >1 publications with Eif4h and Breast Neoplasms
 Esophageal Neoplasms Antibodies  >1 publications with Eif4h and Esophageal Neoplasms
 Head and Neck Neoplasms Antibodies  >1 publications with Eif4h and Head and Neck Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with Eif4h and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-Eif4h antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >1 publications with Eif4h and Eye
 Colon Antibodies  >1 publications with Eif4h and Colon
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