Endoplasmic Reticulum Associated Amyloid Beta Binding Protein Antibody – Rabbit Polyclonal

An intracellular protein termed ERAB (Endoplasmic reticulum associated Ab binding protein on chromosome X) has been cloned and linked with Ab neurotoxicity (1). ERAB has structural homology with short-chain alcohol dehydrogenases (hydroxysteroid dehydrogenases and acetyl-CoA reductases). Interestingly, ERAB localizes to endoplasmic reticulum despite the absence of a classical transmembrane sequence. However, in the presence of Ab, ERAB- Ab complex translates to the inner plasma membrane. Alzheimer patients have strong ERAB activity. Normal brains have virtually no ERAB. In addition, Ab neurotoxicity can be reduced by blocking ERAB and increased by its overexpression.

• 1. Yan SD et al (1997) Nature 389:689.
• 2. Zuchenko OP et al (1997) Accession # Q99717; Furuta S et al (1997) BBA 1350:317-324.

Small volumes of anti-Endoplasmic Reticulum Associated Amyloid Beta Binding Protein antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS618377 is an antibody targeting Endoplasmic Reticulum Associated Amyloid Beta Binding Protein. Also known as Anti - Endoplasmic Reticulum Associated Amyloid Beta Binding Protein (ERAB). Reactive in Bovine, Human, Mouse. Host: Rabbit
Source: Human.