Rabbit Anti-IL3 Polyclonal Antibody – Cat# MBS618559

Western blot analysis of extracts from COS, NIH/3T3, HeLa, C6 and MvlLu cells, using MBS618559.

Il-3, Il-5, Gm-CSF Receptor, Beta-Common (IL3) Antibody – Rabbit Polyclonal

Name: IL3 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS618559
Price: 760 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS618559

The common beta-chain (beta-c) of the granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and IL-5 receptors is the major signaling subunit of these receptors coupling ligand binding to multiple biological activities (1-3).… More details

$760 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IL-3, IL-5, GM-CSF Receptor, beta-common (IL3), Polyclonal Antibody

Full Product Name

IL-3, IL-5, GM-CSF Receptor, beta-common (bc)

Product Gene Name

anti-IL3 antibody

Product Synonym Names

Anti -IL-3, IL-5, GM-CSF Receptor, beta-common (bc)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Monkey, Mouse, Rat

Form/Format

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.

Purity/Purification

Affinity Purified
Purified by Protein A and peptide affinity chromatography.

Specificity

Recognizes endogenous levels of total human cytokine receptor common beta-chain protein at ~100kD independent of phosphorylation. Species Crossreactivity: Mouse, rat, monkey, mink

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

17,233 Da

Chromosome Location

Chromosome: 5; NC_000005.9 (131396347..131398896). Location: 5q31.1

OMIM

147740

3D Structure

ModBase 3D Structure for P08700

Immunogen

Synthetic peptide derived from the C-terminus of human cytokine receptor common beta-chain.

Product Categories/Family for anti-IL3 antibody

Antibodies; Abs to Receptors

Applications Tested/Suitable for anti-IL3 antibody

Western Blot (WB)

Application Notes for anti-IL3 antibody

Suitable for use in Western Blot.
Dilution: Western Blot: 1:1000

Other Notes

Small volumes of anti-IL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL3 purchase

MBS618559 is an antibody targeting IL3. Also known as IL-3, IL-5, GM-CSF Receptor, beta-common (bc). Reactive in Human, Monkey, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IL3. It may not necessarily be applicable to this product.

NCBI GI #

3002475

NCBI GeneID

3562

UniProt Primary Accession #

P08700

UniProt Secondary Accession #

Q6GS87

UniProt Related Accession #

P08700; Q6NZ78; Q6NZ79

NCBI Official Full Name

IL-3

NCBI Official Synonym Full Names

interleukin 3 (colony-stimulating factor, multiple)

NCBI Official Symbol

IL3

NCBI Official Synonym Symbols

IL-3; MCGF; MGC79398; MGC79399; MULTI-CSF

UniProt Protein Name

Interleukin-3

UniProt Synonym Protein Names

Hematopoietic growth factor; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor

Protein Family

Interleukin

UniProt Gene Name

IL3

UniProt Entry Name

IL3_HUMAN

NCBI Protein Information

interleukin-3; OTTHUMP00000065963; mast cell growth factor; mast-cell growth factor; P-cell stimulating factor; P-cell-stimulating factor; hematopoietic growth factor; multilineage-colony-stimulating factor; multipotential colony-stimulating factor

NCBI Summary for IL3

The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq]

UniProt Comments for IL3

IL3: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family.

Protein type: Oncoprotein; Cell cycle regulation; Apoptosis; Secreted, signal peptide; Cytokine; Secreted

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: extracellular space; extracellular region

Molecular Function: interleukin-3 receptor binding; growth factor activity; cytokine activity

Biological Process: nervous system development; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of tyrosine phosphorylation of Stat5 protein; cell-cell signaling; embryonic hemopoiesis; cytokine and chemokine mediated signaling pathway; positive regulation of cell proliferation; immune response; positive regulation of myeloid leukocyte differentiation; positive regulation of DNA replication

Research Articles on IL3

1. The IL3 genotypes rs40401 and rs40401 were found to exert a protective effect against malaria attacks.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL3 antibody

Reference Product	PubMed Publications
CSF2RB antibody	>10 publications with IL3 and CSF2RB
IL3RA antibody	>6 publications with IL3 and IL3RA
PIK3CD antibody	>1 publications with IL3 and PIK3CD
PIK3CA antibody	>1 publications with IL3 and PIK3CA
HRAS antibody	>1 publications with IL3 and HRAS

Pathways associated with anti-IL3 antibody

Products by Pathway	Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Asthma Pathway antibodies	Asthma Pathway Diagram
Asthma Pathway antibodies	Asthma Pathway Diagram
Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies	Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
Calcium Signaling In The CD4+ TCR Pathway antibodies	Calcium Signaling In The CD4+ TCR Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Fc Epsilon RI Signaling Pathway antibodies	Fc Epsilon RI Signaling Pathway Diagram

Diseases associated with anti-IL3 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>115 publications with IL3 and Neoplasms
Leukemia Antibodies	>99 publications with IL3 and Leukemia
Leukemia, Myeloid Antibodies	>67 publications with IL3 and Leukemia, Myeloid
Hematologic Diseases Antibodies	>47 publications with IL3 and Hematologic Diseases
Leukemia, Myeloid, Acute Antibodies	>39 publications with IL3 and Leukemia, Myeloid, Acute
Bone Marrow Diseases Antibodies	>35 publications with IL3 and Bone Marrow Diseases
Hypersensitivity Antibodies	>21 publications with IL3 and Hypersensitivity
Lung Diseases Antibodies	>18 publications with IL3 and Lung Diseases
Neoplasms, Experimental Antibodies	>18 publications with IL3 and Neoplasms, Experimental
Drug Toxicity Antibodies	>17 publications with IL3 and Drug Toxicity

Organs/Tissues associated with anti-IL3 antibody

Organ/Tissue Name	Pubmed Publications
Mixed Antibodies	>11 publications with IL3 and Mixed