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Transforming Growth Factor Beta Receptor III (TGFBR3) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS618581

Most cell types express three different sizes of TGF-Beta receptors. These are designated Type I (53kD), Type II (70-85kD), and Type III (250-350kD). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the… More details

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Product Overview

Online Datasheet in PDF
Product Name
Transforming Growth Factor beta Receptor III (TGFBR3), Polyclonal Antibody
Full Product Name
Transforming Growth Factor beta Receptor III (TGF beta Receptor III, TGF beta RIII, TGFR-3, Betaglycan) (PE)
Product Gene Name
anti-TGFBR3 antibody
Product Synonym Names
Anti -Transforming Growth Factor beta Receptor III (TGF beta Receptor III, TGF beta RIII, TGFR-3, Betaglycan) (PE)
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.1% sodium azide. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human TGF-Beta RIII.
Preparation and Storage
May be stored at 4 degree C before opening. DO NOT FREEZE! Stable at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months at 4 degree C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Molecular Weight
93,499 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (92145900..92351787, complement). Location: 1p33-p32
OMIM
600742
3D Structure
ModBase 3D Structure for Q03167
Immunogen
NS0-derived rhTGF-beta sRIII extracellular domain

Product Categories/Family for anti-TGFBR3 antibody

Antibodies; Abs to Receptors
Applications Tested/Suitable for anti-TGFBR3 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-TGFBR3 antibody
Suitable for use in Flow Cytometry.
Dilution: Flow Cytometry: Neat; Use 10ul to label 10e5 cells.

Testing Data of anti-TGFBR3 antibody

Human lymphocytes were stained with MBS618581 or isotype control
Goat Anti-TGFBR3 Polyclonal Antibody – Cat# MBS618581

Other Notes

Small volumes of anti-TGFBR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TGFBR3 purchase

MBS618581 is an antibody targeting TGFBR3. Also known as Transforming Growth Factor beta Receptor III (TGF beta Receptor III, TGF beta RIII, TGFR-3, Betaglycan) (PE). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for TGFBR3. It may not necessarily be applicable to this product.

NCBI GI #
119593519
NCBI GeneID
7049
UniProt Primary Accession #
Q03167
UniProt Secondary Accession #
Q5T2T4; Q5U731; Q9UGI2; A0AUW8; B9EG88
UniProt Related Accession #
Q03167
NCBI Official Full Name
transforming growth factor, beta receptor III (betaglycan, 300kDa), isoform CRA_b
NCBI Official Synonym Full Names
transforming growth factor, beta receptor III
NCBI Official Symbol
TGFBR3
NCBI Official Synonym Symbols
BGCAN; betaglycan
UniProt Protein Name
Transforming growth factor beta receptor type 3
UniProt Synonym Protein Names
Betaglycan; Transforming growth factor beta receptor III
Protein Family
Transforming growth factor
UniProt Gene Name
TGFBR3
UniProt Entry Name
TGBR3_HUMAN
NCBI Protein Information
transforming growth factor beta receptor type 3; TGFR-3; OTTHUMP00000011787; OTTHUMP00000011807; OTTHUMP00000228692; betaglycan proteoglycan; TGF-beta receptor type 3; TGF-beta receptor type III

NCBI Summary for TGFBR3

This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
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UniProt Comments for TGFBR3

TGFBR3: Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. Interacts with TCTEX1D4. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p33-p32

Cellular Component: proteinaceous extracellular matrix; extracellular space; cell surface; endoplasmic reticulum; integral to plasma membrane; receptor complex; external side of plasma membrane

Molecular Function: heparin binding; transforming growth factor beta receptor activity; protein binding; fibroblast growth factor binding; glycosaminoglycan binding; transforming growth factor beta binding; punt binding; activin binding; coreceptor activity; SMAD binding; transforming growth factor beta receptor binding; PDZ domain binding

Biological Process: heart morphogenesis; transforming growth factor beta receptor complex assembly; blood vessel development; blastocyst development; organ regeneration; cell migration; positive regulation of transforming growth factor beta receptor signaling pathway; cardiac muscle cell proliferation; negative regulation of cell motility; palate development; liver development; activation of NF-kappaB transcription factor; BMP signaling pathway; regulation of protein binding; transforming growth factor beta receptor signaling pathway; response to hypoxia; ventricular cardiac muscle morphogenesis; epithelial to mesenchymal transition; immune response; negative regulation of transforming growth factor beta receptor signaling pathway; cell growth; response to follicle-stimulating hormone stimulus; negative regulation of epithelial cell proliferation
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Research Articles on TGFBR3

1. endometrial cancer is associated with disruption of accessory receptor betaglycan expression, what may alter TGFbeta2-induced signaling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TGFBR3 antibody

 Reference Product  PubMed Publications
 TGFB1 antibody  >79 publications with TGFBR3 and TGFB1
 TGFB2 antibody  >39 publications with TGFBR3 and TGFB2
 TGFB3 antibody  >22 publications with TGFBR3 and TGFB3
 ENG antibody  >21 publications with TGFBR3 and ENG
 TGFBR2 antibody  >9 publications with TGFBR3 and TGFBR2
 SDC2 antibody  >3 publications with TGFBR3 and SDC2

Pathways associated with anti-TGFBR3 antibody

 Products by Pathway  Pathway Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram

Diseases associated with anti-TGFBR3 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >81 publications with TGFBR3 and Neoplasms
 Carcinoma Antibodies  >30 publications with TGFBR3 and Carcinoma
 Fibrosis Antibodies  >17 publications with TGFBR3 and Fibrosis
 Adenocarcinoma Antibodies  >16 publications with TGFBR3 and Adenocarcinoma
 Inflammation Antibodies  >14 publications with TGFBR3 and Inflammation
 Breast Neoplasms Antibodies  >14 publications with TGFBR3 and Breast Neoplasms
 Gonadal Disorders Antibodies  >11 publications with TGFBR3 and Gonadal Disorders
 Lung Neoplasms Antibodies  >9 publications with TGFBR3 and Lung Neoplasms
 Prostatic Neoplasms Antibodies  >8 publications with TGFBR3 and Prostatic Neoplasms
 Ovarian Neoplasms Antibodies  >8 publications with TGFBR3 and Ovarian Neoplasms

Organs/Tissues associated with anti-TGFBR3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >52 publications with TGFBR3 and Blood
 Bone Antibodies  >48 publications with TGFBR3 and Bone
 Vascular Antibodies  >40 publications with TGFBR3 and Vascular
 Lung Antibodies  >32 publications with TGFBR3 and Lung
 Ovary Antibodies  >29 publications with TGFBR3 and Ovary
 Muscle Antibodies  >26 publications with TGFBR3 and Muscle
 Brain Antibodies  >26 publications with TGFBR3 and Brain
 Pituitary Gland Antibodies  >23 publications with TGFBR3 and Pituitary Gland
 Connective Tissue Antibodies  >19 publications with TGFBR3 and Connective Tissue
 Kidney Antibodies  >16 publications with TGFBR3 and Kidney
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