WNK1 Antibody – Rabbit Polyclonal

Protein kinases represent a superfamily of over 400 members that share a catalytic domain of 250-300 amino acids. A conserved lysine, in subdomain II of the catalytic core of all 390 protein kinases, anchors a and b phosphoryl groups of ATP. The catalytic domain of WNK (With No K=Lysine) kinases contains all invariant residues, except for this lysine residue. There are 4 (identified) WNK genes (WNK1, WNK2, WNK3 and WNK4) in human (h) and rat (r). The hWNK kinases exhibit ~30% seq identity and 50% seq homology to human Mitogen Activated Protein kinases (MAPK) STK2, PAK2, MEKK3, PAK3 and Raf-1. The mutation in genes expressing WNK1 (chromosome 12p13.3) and WNK4 (chromosome 17q) causes Pseudohypoaldosteronism type II (PHAII), an autosomal disorder featuring hypertension, hyperkalemia (high serum K+ level), normal/elevated aldosterone level, increased renal salt absorption, and impaired K+ and H+ excretion.

• 1. Moorre TM et al (2000) JBC 275, 4311; Wilson et al. (2001) Science 293, 1107; Xu B et al. (2000) JBC 275, 16795; Verissimo and Jordan (2001) Oncogene 20, 5562; Ito et al. (2001) Cancer Res. 61, 2038.

Small volumes of anti-WNK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS618586 is an antibody targeting WNK1. Also known as Anti - WNK1 (Kinase deficient protein, Protein kinase lysine deficient 1, Protein kinase with no lysine 1, Serine/threonine protein kinase WNK1). Reactive in Human. Host: Rabbit
Source: Human.