DKK1 Antibody – Mouse Monoclonal

This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq]

1. Genetic grouping of medulloblastomas by representative markers in pathologic diagnosis. Min HS, Lee JY, Kim SK, Park SHTransl Oncol. 2013 Jun 1;6(3):265-72. Print 2013 Jun. 2.RNA interference?mediated targeting of DKK1 gene expression in Ishikawa endometrial carcinoma cells causes increased tumor cell invasion and migration.Yi N, Liao QP, Li ZH, Xie BJ, Hu YH, Yi W, Liu M.ONCOLOGY LETTERS 6: 756-762, 2013 3.Molecular subgroups of medulloblastoma: the current consensus. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, Eberhart CG, Parsons DW, Rutkowski S, Gajjar A, Ellison DW, Lichter P, Gilbertson RJ, Pomeroy SL, Kool M, Pfister SM.Acta Neuropathol. 2011 Dec 2. 4.Prokineticin 1 induces Dickkopf 1 expression and regulates cell proliferation and decidualization in the human endometrium. Macdonald LJ, Sales KJ, Grant V, Brown P, Jabbour HN, Catalano RD.Mol Hum Reprod. 2011 May 5. 5. Carbonic anhydrase IX (CA9) modulates tumor-associated cell migration and invasion.Shin HJ, Rho SB, Jung DC, Han IO, Oh ES, Kim JY.J Cell Sci. 2011 Apr 1;124(Pt 7):1077-87. Epub 2011 Mar 1. 6.Bone and bone marrow pro-osteoclastogenic cytokines are up-regulated in osteoporosis fragility fractures.D'Amelio P, Roato I, D'Amico L, Veneziano L, Suman E, Sassi F, Bisignano G, Ferracini R, Gargiulo G, Castoldi F, Pescarmona GP, Isaia GC.Osteoporos Int. 2010 Nov 30.

Small volumes of anti-DKK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS6185894 is an antibody targeting DKK1. Also known as DKK1 (Dickkopf Homolog 1 (Xenopus laevis), DKK-1, SK) (PE). Host: Mouse.