Rabbit Anti-SUV420H1 Polyclonal Antibody – Cat# MBS618756

SUV420H1 Antibody – Rabbit Polyclonal

Name: SUV420H1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS618756
Price: 1045 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS618756

The Hey family of bHLH transcription factors are direct targets of Notch signaling. HEY2 (gridlock) is an important determinant of mammalian heart development, loss of which in mouse leads to cardiac defects with high postnatal lethality. Mouse Hey1 knockouts… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HEY 2 (SUV420H1), Polyclonal Antibody

Full Product Name

HEY 2 (Helix-loop-helix Transcription Factor, Hairy/enhancer-of-split related with YRPW motif 2, bHLHb32, BHLHB32, Cardiovascular helix-loop-helix factor 1, CHF1, Class B basic helix-loop-helix protein 32, GRIDLOCK, GRL, Hairy and enhancer of split-relate

Product Gene Name

anti-SUV420H1 antibody

Product Synonym Names

Anti -HEY 2 (Helix-loop-helix Transcription Factor, Hairy/enhancer-of-split related with YRPW motif 2, bHLHb32, BHLHB32, Cardiovascular helix-loop-helix factor 1, CHF1, Class B basic helix-loop-helix protein 32, GRIDLOCK, GRL, Hairy and enhancer of split-relate

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Rodent

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added.

Purity/Purification

Affinity Purified
Purified by affinity chromatography.

Specificity

Recognizes human Hey 2/HRT2. Species Crossreactivity: rodent.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

99,187 Da

Chromosome Location

Chromosome: 11; NC_000011.9 (67922330..67981250, complement). Location: 11q13.2

OMIM

610881

3D Structure

ModBase 3D Structure for Q4FZB7

Immunogen

Synthetic peptide corresponding to aa314-330 of human Hey 2/HRT2.

Product Categories/Family for anti-SUV420H1 antibody

Antibodies; Abs to Transcription Factors

Applications Tested/Suitable for anti-SUV420H1 antibody

Immunohistochemistry (IHC)

Application Notes for anti-SUV420H1 antibody

Suitable for use in Immunohistochemistry.
Dilution: Immunohistochemistry: 1:200-1:1000

Other Notes

Small volumes of anti-SUV420H1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SUV420H1 purchase

MBS618756 is an antibody targeting SUV420H1. Also known as HEY 2 (Helix-loop-helix Transcription Factor, Hairy/enhancer-of-split related with YRPW motif 2, bHLHb32, BHLHB32, Cardiovascular helix-loop-helix factor 1, CHF1, Class B basic helix-loop-helix protein 32, GRIDLOCK, GRL, Hairy and enhancer of split-relate. Reactive in Human, Rodent. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SUV420H1. It may not necessarily be applicable to this product.

NCBI GI #

50659084

NCBI GeneID

51111

NCBI Accession #

NP_057112.3

UniProt Primary Accession #

Q4FZB7

UniProt Secondary Accession #

Q3SX56; Q4V775; Q6P150; Q96E44; Q9BUL0; Q9H022; Q9H2K3; Q9NXV3; Q9Y393; B7WNX7

UniProt Related Accession #

Q4FZB7

GenBank Nucleotide #

NM_016028.4

NCBI Official Full Name

histone-lysine N-methyltransferase SUV420H1 isoform 2

NCBI Official Synonym Full Names

suppressor of variegation 4-20 homolog 1 (Drosophila)

NCBI Official Symbol

SUV420H1

NCBI Official Synonym Symbols

CGI85; KMT5B; CGI-85

UniProt Protein Name

Histone-lysine N-methyltransferase SUV420H1

UniProt Synonym Protein Names

Lysine N-methyltransferase 5B; Suppressor of variegation 4-20 homolog 1

UniProt Gene Name

SUV420H1

UniProt Synonym Gene Names

KMT5B; Su(var)4-20 homolog 1; Suv4-20h1

UniProt Entry Name

SV421_HUMAN

NCBI Protein Information

histone-lysine N-methyltransferase SUV420H1; suv4-20h1; C630029K18Rik; su(var)4-20 homolog 1; lysine N-methyltransferase 5B

NCBI Summary for SUV420H1

This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for SUV420H1

SUV420H1: a protein methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Strongly down-regulated in breast cancer cells. Belongs to the histone-lysine methyltransferase family. Suvar4-20 subfamily. Three alternatively-spliced isoforms have been described.

Protein type: Methyltransferase; Methyltransferase, protein lysine; EC 2.1.1.43; Amino Acid Metabolism - lysine degradation

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: condensed nuclear chromosome, pericentric region

Molecular Function: histone lysine N-methyltransferase activity (H4-K20 specific); histone-lysine N-methyltransferase activity

Biological Process: muscle development; transcription, DNA-dependent; regulation of transcription, DNA-dependent

Research Articles on SUV420H1

1. SUV420H1 and SUV420H2 isoforms have different in their cellular localization and effects on myogenic differentiation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SUV420H1 antibody

Products by Pathway	Pathway Diagram
Glucocorticoid Receptor Regulatory Network Pathway antibodies	Glucocorticoid Receptor Regulatory Network Pathway Diagram
Lysine Degradation Pathway antibodies	Lysine Degradation Pathway Diagram
Lysine Degradation Pathway antibodies	Lysine Degradation Pathway Diagram

Diseases associated with anti-SUV420H1 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>1 publications with SUV420H1 and Neoplasms

Organs/Tissues associated with anti-SUV420H1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1 publications with SUV420H1 and Blood
Muscle Antibodies	>1 publications with SUV420H1 and Muscle
Brain Antibodies	>1 publications with SUV420H1 and Brain