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KIF2A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS618973

Kif2a is a kinesin-like motor protein that depolymerizes microtubules. It is found in several vertebrate cell types but is strongly expressed in neuronal cells. In dividing cells it is required for bipolar spindle formation and chromosome segregation. In… More details

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Product Overview

Online Datasheet in PDF
Product Name
KIF2A, Polyclonal Antibody
Full Product Name
KIF2A (Kinesin Heavy Chain Member 2A, Kinesin-like Protein KIF2A, HK2, Kinesin 2, KNS2, M-Kinesin)
Product Gene Name
anti-KIF2A antibody
Product Synonym Names
Anti -KIF2A (Kinesin Heavy Chain Member 2A, Kinesin-like Protein KIF2A, HK2, Kinesin 2, KNS2, M-Kinesin)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Serum
Whole antisera
Specificity
This antibody is specific for Kif2a. Species Crossreactivity: Reactive to most vertebrate species.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
79,955 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (61601989..61682210). Location: 5q12-q13
OMIM
602591
3D Structure
ModBase 3D Structure for O00139
Immunogen
Produced by immunizing rabbits with a recombinant segment of the N-terminal domain of the human protein.

Product Categories/Family for anti-KIF2A antibody

Antibodies; Abs to Motor Proteins
Applications Tested/Suitable for anti-KIF2A antibody
Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
Application Notes for anti-KIF2A antibody
Suitable for use in Immunofluorescence, Western Blot and Immunoprecipitation.

Other Notes

Small volumes of anti-KIF2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KIF2A purchase

MBS618973 is an antibody targeting KIF2A. Also known as KIF2A (Kinesin Heavy Chain Member 2A, Kinesin-like Protein KIF2A, HK2, Kinesin 2, KNS2, M-Kinesin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KIF2A. It may not necessarily be applicable to this product.

NCBI GI #
148612877
NCBI GeneID
3796
NCBI Accession #
NP_004511.2
UniProt Primary Accession #
O00139
UniProt Secondary Accession #
Q7Z5I3; Q8N5Q7; A5YM42; A5YM54; B4DY54; D3DW97
UniProt Related Accession #
O00139
GenBank Nucleotide #
NM_004520.3
NCBI Official Full Name
kinesin-like protein KIF2A isoform 1
NCBI Official Synonym Full Names
kinesin heavy chain member 2A
NCBI Official Symbol
KIF2A
NCBI Official Synonym Symbols
HK2; KIF2
UniProt Protein Name
Kinesin-like protein KIF2A
UniProt Synonym Protein Names
Kinesin-2
Protein Family
Kinesin-like protein
UniProt Gene Name
KIF2A
UniProt Synonym Gene Names
KIF2; KNS2
UniProt Entry Name
KIF2A_HUMAN
NCBI Protein Information
kinesin-like protein KIF2A; kinesin-2; OTTHUMP00000123384; OTTHUMP00000197299; OTTHUMP00000197300; OTTHUMP00000221863; Kinesin, heavy chain, 2

NCBI Summary for KIF2A

Kinesins, such as KIF2, are microtubule-associated motor proteins. For background information on kinesins, see MIM 148760.[supplied by OMIM]

UniProt Comments for KIF2A

KIF2A: Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Microtubule-binding; Motor

Chromosomal Location of Human Ortholog: 5q12-q13

Cellular Component: spindle pole; centrosome; kinesin complex; membrane; spindle microtubule; cytosol

Molecular Function: protein binding; microtubule binding; ATPase activity; motor activity; microtubule motor activity; ATP binding

Biological Process: nervous system development; mitotic spindle organization and biogenesis; metabolic process; cell division; microtubule depolymerization; antigen processing and presentation of exogenous peptide antigen via MHC class II; mitotic cell cycle; blood coagulation; cell differentiation; microtubule-based movement

Disease: Cortical Dysplasia, Complex, With Other Brain Malformations 3
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Research Articles on KIF2A

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-KIF2A antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Kinesins Pathway antibodies  Kinesins Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic M-M/G1 Phases Pathway antibodies  Mitotic M-M/G1 Phases Pathway Diagram
 Mitotic Prometaphase Pathway antibodies  Mitotic Prometaphase Pathway Diagram
 PLK1 Signaling Events Pathway antibodies  PLK1 Signaling Events Pathway Diagram

Diseases associated with anti-KIF2A antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with KIF2A and Neoplasms
 Breast Neoplasms Antibodies  >1 publications with KIF2A and Breast Neoplasms
 Inflammation Antibodies  >1 publications with KIF2A and Inflammation

Organs/Tissues associated with anti-KIF2A antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >7 publications with KIF2A and Nerve
 Brain Antibodies  >7 publications with KIF2A and Brain
 Placenta Antibodies  >2 publications with KIF2A and Placenta
 Kidney Antibodies  >2 publications with KIF2A and Kidney
 Eye Antibodies  >1 publications with KIF2A and Eye
 Lymph Node Antibodies  >1 publications with KIF2A and Lymph Node
 Testis Antibodies  >1 publications with KIF2A and Testis
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