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PRKRA Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS618979

Principal Names: Retinal and anterior neural fold Homeobox (Rax); Retinal Homeobox protein Rx; Official Gene Symbol: RAX Gen Bank Accession Number: NP_038463 Gene ID: 30062 (Human) Gene Map Locus: 18q21.32 (Human) Rax, a novel transcription factor, is a human… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Protein Kinase, Interferon-inducible Double Stranded RNA Dependent Activator (PRKRA), Polyclonal Antibody
Full Product Name
Protein Kinase, Interferon-inducible Double Stranded RNA Dependent Activator (PRKRA, PACT, Retina and Anterior Neural Fold Homeobox Protein, RAX, Retinal Homeobox Protein, Retinal Homeobox Protein Rx, RX, RX Homeobox)
Product Gene Name
anti-PRKRA antibody
Product Synonym Names
Anti -Protein Kinase, Interferon-inducible Double Stranded RNA Dependent Activator (PRKRA, PACT, Retina and Anterior Neural Fold Homeobox Protein, RAX, Retinal Homeobox Protein, Retinal Homeobox Protein Rx, RX, RX Homeobox)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Canine, Human, Monkey
Form/Format
Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
Purity/Purification
Affinity Purified
Purified by peptide immunoaffinity chromatography.
Specificity
The amino acid sequence used as immunogen is 100% homologous in human, canine, monkey, 85% homologous in chicken and 78% homologous in zebrafish, mouse and rat. Species Crossreactivity: canine, Human, Monkey
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
34,404 Da
Chromosome Location
chromosome: 2; Location: 2q31.2
OMIM
603424
3D Structure
ModBase 3D Structure for O75569
Positive Control
Jurkat cell lysate

Product Categories/Family for anti-PRKRA antibody

Antibodies; Abs to Transcription Factors; Homeobox (HOX)
Applications Tested/Suitable for anti-PRKRA antibody
Western Blot (WB)
Application Notes for anti-PRKRA antibody
Suitable for use in Western Blot.

Other Notes

Small volumes of anti-PRKRA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRKRA purchase

MBS618979 is an antibody targeting PRKRA. Also known as Protein Kinase, Interferon-inducible Double Stranded RNA Dependent Activator (PRKRA, PACT, Retina and Anterior Neural Fold Homeobox Protein, RAX, Retinal Homeobox Protein, Retinal Homeobox Protein Rx, RX, RX Homeobox). Reactive in Canine, Human, Monkey. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PRKRA. It may not necessarily be applicable to this product.

NCBI GI #
30583325
NCBI GeneID
8575
UniProt Primary Accession #
O75569
UniProt Secondary Accession #
Q53G24; Q6X7T5; Q8NDK4; A8K3I6
UniProt Related Accession #
O75569
NCBI Official Full Name
protein kinase, interferon-inducible double stranded RNA dependent activator
NCBI Official Synonym Full Names
protein kinase, interferon-inducible double stranded RNA dependent activator
NCBI Official Symbol
PRKRA
NCBI Official Synonym Symbols
RAX; PACT; DYT16; HSD14; PRKRA
UniProt Protein Name
Interferon-inducible double stranded RNA-dependent protein kinase activator A
UniProt Synonym Protein Names
PKR-associated protein X; PKR-associating protein X; Protein activator of the interferon-induced protein kinase; Protein kinase, interferon-inducible double stranded RNA-dependent activator
Protein Family
Interferon-inducible double-stranded RNA-dependent protein kinase activator
UniProt Gene Name
PRKRA
UniProt Synonym Gene Names
PACT; RAX
UniProt Entry Name
PRKRA_HUMAN
NCBI Protein Information
interferon-inducible double stranded RNA-dependent protein kinase activator A; OTTHUMP00000205652; PKR-associated protein X; PKR-associating protein X; protein activator of the interferon-induced protein kinase; protein kinase, interferon-inducible double stranded RNA-dependent activator

NCBI Summary for PRKRA

This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

UniProt Comments for PRKRA

PACT: a double strand RNA binding protein (dsRBP). Interacts with TRBP and Dicer to stimulate the cleavage of double-stranded or short hairpin RNA to siRNA. Appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor. Activates the interferon-induced protein kinase PKR. Three alternatively spliced human isoforms have been reported.

Protein type: RNA processing; RNA-binding; Activator

Chromosomal Location of Human Ortholog: 2q31.2

Cellular Component: nucleoplasm; membrane; perinuclear region of cytoplasm; cytoplasm; cytosol

Molecular Function: protein binding; protein homodimerization activity; enzyme activator activity

Biological Process: positive regulation of catalytic activity; negative regulation of cell proliferation; skeletal morphogenesis; response to virus; outer ear morphogenesis; gene expression; immune response; middle ear morphogenesis; protein amino acid phosphorylation; RNA interference, production of siRNA

Disease: Dystonia 16
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Research Articles on PRKRA

1. Observational study of gene-disease association. (HuGE Navigator)
2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
3. writer's cramp as presenting symptom is not associated with mutations in DYT11, DYT16, but it can be the sole manifestation of DYT1 GAG deletion mutation carriers.
4. Strong protein kinase R (PKR) binding is needed for PACT-mediated PKR activation and phosphorylation in vivo.
5. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
6. DYT16, a novel young-onset dystonia-parkinsonism disorder, identification of a segregating mutation in the stress-response protein PRKRA.
7. TRBP controls PACT activation of PKR, an activity that is reversed by stress.
8. A heterozygous frameshift mutation in PRKRA (DYT16) associated with generalised dystonia in a German patient.
9. Results indicate that human TRBP and PACT directly interact with each other and associate with Dicer to stimulate the cleavage of double-stranded or short hairpin RNA to siRNA.
10. Us11 protein of herpes simplex virus type 1 can block PKR activation by PACT both in vitro and in vivo
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PRKRA antibody

 Reference Product  PubMed Publications
 RB1 antibody  >5 publications with PRKRA and RB1
 TARBP2 antibody  >2 publications with PRKRA and TARBP2
 EIF2C2 antibody  >2 publications with PRKRA and EIF2C2
 DICER1 antibody  >2 publications with PRKRA and DICER1

Pathways associated with anti-PRKRA antibody

 Products by Pathway  Pathway Diagram
 Ceramide Signaling Pathway antibodies  Ceramide Signaling Pathway Diagram

Diseases associated with anti-PRKRA antibody

 Disease Name  Pubmed Publications
 Dystonia Antibodies  >9 publications with PRKRA and Dystonia
 Neoplasms Antibodies  >5 publications with PRKRA and Neoplasms
 Neurodegenerative Diseases Antibodies  >4 publications with PRKRA and Neurodegenerative Diseases
 Adenocarcinoma Antibodies  >2 publications with PRKRA and Adenocarcinoma
 Breast Neoplasms Antibodies  >1 publications with PRKRA and Breast Neoplasms
 Adenoma Antibodies  >1 publications with PRKRA and Adenoma
 Hyperplasia Antibodies  >1 publications with PRKRA and Hyperplasia

Organs/Tissues associated with anti-PRKRA antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with PRKRA and Brain
 Blood Antibodies  >3 publications with PRKRA and Blood
 Muscle Antibodies  >2 publications with PRKRA and Muscle
 Ganglia Antibodies  >2 publications with PRKRA and Ganglia
 Testis Antibodies  >2 publications with PRKRA and Testis
 Intestine Antibodies  >1 publications with PRKRA and Intestine
 Eye Antibodies  >1 publications with PRKRA and Eye
 Ear Antibodies  >1 publications with PRKRA and Ear
 Pituitary Gland Antibodies  >1 publications with PRKRA and Pituitary Gland
 Lung Antibodies  >1 publications with PRKRA and Lung
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