ENPP3 Antibody – Mouse Monoclonal

The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Oct 2015]

ENPP3: Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

Protein type: Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Nucleotide Metabolism - purine; EC 3.1.4.1; Phosphodiesterase; Motility/polarity/chemotaxis; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cofactor and Vitamin Metabolism - riboflavin; Carbohydrate Metabolism - starch and sucrose; Membrane protein, integral; EC 3.6.1.9

Chromosomal Location of Human Ortholog: 6q22

Cellular Component: perinuclear region of cytoplasm; integral to plasma membrane

Molecular Function: nucleotide diphosphatase activity; phosphodiesterase I activity; nucleic acid binding; metal ion binding; nucleoside-triphosphate diphosphatase activity; scavenger receptor activity; polysaccharide binding

Biological Process: receptor-mediated endocytosis; nucleoside triphosphate catabolic process; immune response; phosphate metabolic process; inorganic diphosphate transport