Goat Anti-AKAP3 Polyclonal Antibody – Cat# MBS619013

Western blot analysis of AKAP3 in Human Testis lysate (35μg protein in RIPA buffer) using AKAP3 antibody (1μg/ml).

AKAP3 Antibody – Goat Polyclonal

Name: AKAP3 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS619013
Price: 980 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS619013

A-kinase anchor proteins (AKAPs) direct the activity of protein kinase A (PKA) by tethering the enzyme near its physiologic substrates. May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction… More details

$980 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AKAP3, Polyclonal Antibody

Full Product Name

AKAP3 (SOB1, FSP95, PRKA3, AKAP110, A Kinase (PRKA) Anchor Protein 3, Fibrousheathin 1, Sperm Oocyte Binding Protein 1)

Product Gene Name

anti-AKAP3 antibody

Product Synonym Names

Anti -AKAP3 (SOB1, FSP95, PRKA3, AKAP110, A Kinase (PRKA) Anchor Protein 3, Fibrousheathin 1, Sperm Oocyte Binding Protein 1)

Clonality

Polyclonal

Host

Goat

Species Reactivity

Human

Form/Format

Supplied as a liquid in Tris-saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes human AKAP3 at ~90kD in Human Testis lysates (calculated MW of 95kD according to NP_006413).

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

94,751 Da

Chromosome Location

Chromosome: 12; NC_000012.11 (4724676..4754343, complement). Location: 12p13.3

OMIM

604689

3D Structure

ModBase 3D Structure for O75969

Immunogen

Synthetic peptide corresponding to human AKAP3.

Product Categories/Family for anti-AKAP3 antibody

Antibodies; Abs to Protein Kinases

Applications Tested/Suitable for anti-AKAP3 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-AKAP3 antibody

Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:32000
Western Blot: 1-3ug/ml

Other Notes

Small volumes of anti-AKAP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AKAP3 purchase

MBS619013 is an antibody targeting AKAP3. Also known as AKAP3 (SOB1, FSP95, PRKA3, AKAP110, A Kinase (PRKA) Anchor Protein 3, Fibrousheathin 1, Sperm Oocyte Binding Protein 1). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for AKAP3. It may not necessarily be applicable to this product.

NCBI GI #

21493041

NCBI GeneID

10566

NCBI Accession #

NP_006413.2

UniProt Primary Accession #

O75969

UniProt Secondary Accession #

O75945; Q86X01; Q9UM61

UniProt Related Accession #

O75969

GenBank Nucleotide #

NM_006422.2

NCBI Official Full Name

A-kinase anchor protein 3

NCBI Official Synonym Full Names

A kinase (PRKA) anchor protein 3

NCBI Official Symbol

AKAP3

NCBI Official Synonym Symbols

CT82; SOB1; FSP95; PRKA3; AKAP110

UniProt Protein Name

A-kinase anchor protein 3

UniProt Synonym Protein Names

A-kinase anchor protein 110 kDa; AKAP 110; Cancer/testis antigen 82; CT82; Fibrous sheath protein of 95 kDa; FSP95; Fibrousheathin I; Fibrousheathin-1; Protein kinase A-anchoring protein 3; PRKA3; Sperm oocyte-binding protein

Protein Family

A-kinase anchor protein

UniProt Gene Name

AKAP3

UniProt Synonym Gene Names

AKAP110; SOB1

UniProt Entry Name

AKAP3_HUMAN

NCBI Protein Information

A-kinase anchor protein 3; AKAP-3; AKAP 110; fibrousheathin 1; fibrousheathin I; fibrousheathin-1; OTTHUMP00000238368; cancer/testis antigen 82; fibrous sheath protein, 95kDa; sperm oocyte-binding protein 1; A-kinase anchor protein 110 kDa; A-kinase anchor protein, 110kDa; Fibrous Sheath Protein of 95 kDa; protein kinase A anchoring protein 3; protein kinase A-anchoring protein 3

NCBI Summary for AKAP3

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family, and is expressed in testis only. The encoded protein contains an RII-binding domain, and is predicted to participate in protein-protein interactions with the R-subunit of the PKA. This protein is localized to the ribs of the fibrous sheath in the principal piece of the sperm tail. It may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. [provided by RefSeq]

UniProt Comments for AKAP3

AKAP3: May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. Belongs to the AKAP110 family.

Protein type: Adaptor/scaffold; Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: cytoplasm; acrosome; nucleus

Molecular Function: protein binding; protein kinase A binding

Biological Process: protein localization; single fertilization; acrosome reaction; transmembrane receptor protein serine/threonine kinase signaling pathway; cell motility

Research Articles on AKAP3

1. CABYR variants form a complex not only with the scaffolding protein AKAP3 but also with another RII-like domain-containing protein in the sperm fibrous sheath.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AKAP3 antibody

Reference Product	PubMed Publications
AKAP4 antibody	>13 publications with AKAP3 and AKAP4
SPA17 antibody	>1 publications with AKAP3 and SPA17
PRKAR2A antibody	>1 publications with AKAP3 and PRKAR2A
GNA13 antibody	>1 publications with AKAP3 and GNA13

Pathways associated with anti-AKAP3 antibody

Products by Pathway	Pathway Diagram
G Protein Signaling Pathways antibodies	G Protein Signaling Pathways Diagram

Diseases associated with anti-AKAP3 antibody

Disease Name	Pubmed Publications
Infertility, Male Antibodies	>8 publications with AKAP3 and Infertility, Male
Ovarian Neoplasms Antibodies	>2 publications with AKAP3 and Ovarian Neoplasms
Gonadal Disorders Antibodies	>2 publications with AKAP3 and Gonadal Disorders
Carcinoma Antibodies	>1 publications with AKAP3 and Carcinoma
Infertility, Female Antibodies	>1 publications with AKAP3 and Infertility, Female
Recurrence Antibodies	>1 publications with AKAP3 and Recurrence

Organs/Tissues associated with anti-AKAP3 antibody

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>7 publications with AKAP3 and Testis
Brain Antibodies	>1 publications with AKAP3 and Brain