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TCF21 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS619032

The basic helix-loop-helix transcription factor TCF21/Pod1 (also called capsulin or epicardin) is involved in kidney, lung and spleen organogenesis. It is also essential for normal development of the testes and ovaries. TCF21/Pod1 is involved in the… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
TCF21, Polyclonal Antibody
Full Product Name
TCF21 (Transcription Factor 21, Capsulin, Epicardin, Podocyte-expressed 1, POD 1, POD1, POD-1)
Product Gene Name
anti-TCF21 antibody
Product Synonym Names
Anti -TCF21 (Transcription Factor 21, Capsulin, Epicardin, Podocyte-expressed 1, POD 1, POD1, POD-1)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Tris-citrate/phosphate [pH 7-8]
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
This antibody is specific for TCF21 protein.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 3 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
19,715 Da
Chromosome Location
Chromosome: 6; NC_000006.11 (134210259..134216675). Location: 6q23-q24
OMIM
603306
3D Structure
ModBase 3D Structure for O43680
Immunogen
A synthetic peptide made to an internal region of human TCF21 protein (within residues 100-179). [Swiss-Prot# O43680]. Homology: 100% Hu, Rt, Bv 90% Mu, Xp

Product Categories/Family for anti-TCF21 antibody

Antibodies; Abs to Transcription Factors
Applications Tested/Suitable for anti-TCF21 antibody
Western Blot (WB)
Application Notes for anti-TCF21 antibody
Suitable for use in Western Blot.

Other Notes

Small volumes of anti-TCF21 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TCF21 purchase

MBS619032 is an antibody targeting TCF21. Also known as TCF21 (Transcription Factor 21, Capsulin, Epicardin, Podocyte-expressed 1, POD 1, POD1, POD-1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TCF21. It may not necessarily be applicable to this product.

NCBI GI #
38202239
NCBI GeneID
6943
NCBI Accession #
NP_938206.1
UniProt Primary Accession #
O43680
UniProt Secondary Accession #
O43545; Q6ICV0; Q9BZ14; E1P581
UniProt Related Accession #
O43680
GenBank Nucleotide #
NM_198392.2
NCBI Official Full Name
transcription factor 21
NCBI Official Synonym Full Names
transcription factor 21
NCBI Official Symbol
TCF21
NCBI Official Synonym Symbols
POD1; bHLHa23
UniProt Protein Name
Transcription factor 21
UniProt Synonym Protein Names
Capsulin; Class A basic helix-loop-helix protein 23; bHLHa23; Epicardin; Podocyte-expressed 1
Protein Family
Transcription factor
UniProt Gene Name
TCF21
UniProt Synonym Gene Names
BHLHA23; POD1
UniProt Entry Name
TCF21_HUMAN
NCBI Protein Information
transcription factor 21; pod-1; TCF-21; capsulin; epicardin; OTTHUMP00000017238; OTTHUMP00000017239; podocyte-expressed 1; class A basic helix-loop-helix protein 23

NCBI Summary for TCF21

TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
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UniProt Comments for TCF21

TCF21: Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.

Protein type: DNA-binding; Deacetylase; Motility/polarity/chemotaxis; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 6q23.2

Cellular Component: nucleus

Molecular Function: protein dimerization activity; androgen receptor binding; histone deacetylase binding; bHLH transcription factor binding

Biological Process: spleen development; gland development; transcription, DNA-dependent; Sertoli cell differentiation; branchiomeric skeletal muscle development; morphogenesis of a branching structure; negative regulation of transcription from RNA polymerase II promoter; palate development; glomerulus development; sex determination; vasculature development; epithelial cell differentiation; embryonic digestive tract morphogenesis; ureteric bud development; ureteric bud branching; positive regulation of transcription from RNA polymerase II promoter; kidney development; alveolus development; reproductive structure development
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Research Articles on TCF21

1. Hypermethylation and decreased expression of TCF21 were tumor specific and very frequent in all NSCLCs, even early-stage disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TCF21 antibody

 Reference Product  PubMed Publications
 TCF3 antibody  >2 publications with TCF21 and TCF3

Diseases associated with anti-TCF21 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >8 publications with TCF21 and Neoplasms
 Lung Neoplasms Antibodies  >6 publications with TCF21 and Lung Neoplasms
 Carcinoma Antibodies  >6 publications with TCF21 and Carcinoma
 Lung Diseases Antibodies  >5 publications with TCF21 and Lung Diseases
 Kidney Diseases Antibodies  >5 publications with TCF21 and Kidney Diseases
 Female Urogenital Diseases Antibodies  >4 publications with TCF21 and Female Urogenital Diseases
 Male Urogenital Diseases Antibodies  >4 publications with TCF21 and Male Urogenital Diseases
 Adenocarcinoma Antibodies  >3 publications with TCF21 and Adenocarcinoma
 Congenital Abnormalities Antibodies  >3 publications with TCF21 and Congenital Abnormalities
 Cardiovascular Diseases Antibodies  >2 publications with TCF21 and Cardiovascular Diseases

Organs/Tissues associated with anti-TCF21 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >20 publications with TCF21 and Kidney
 Lung Antibodies  >15 publications with TCF21 and Lung
 Embryonic Tissue Antibodies  >14 publications with TCF21 and Embryonic Tissue
 Heart Antibodies  >12 publications with TCF21 and Heart
 Spleen Antibodies  >7 publications with TCF21 and Spleen
 Connective Tissue Antibodies  >2 publications with TCF21 and Connective Tissue
 Stomach Antibodies  >2 publications with TCF21 and Stomach
 Intestine Antibodies  >1 publications with TCF21 and Intestine
 Liver Antibodies  >1 publications with TCF21 and Liver
 Pancreas Antibodies  >1 publications with TCF21 and Pancreas
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