Mouse Anti-RICTOR Monoclonal Antibody – Cat# MBS6192291

RICTOR Antibody – Mouse Monoclonal

Name: RICTOR Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6192291
Price: 960 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6192291

MBS6192291 is an antibody targeting RICTOR. Also known as RICTOR (Rapamycin-insensitive Companion of mTOR, AVO3 Homolog, hAVO3, KIAA1999, mAVO3, PIA) (MaxLight 405). Reactive in Human. Host: Mouse. More details

$960 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RICTOR, Monoclonal Antibody

Full Product Name

RICTOR (Rapamycin-insensitive Companion of mTOR, AVO3 Homolog, hAVO3, KIAA1999, mAVO3, PIA) (MaxLight 405)

Product Gene Name

anti-RICTOR antibody

Product Synonym Names

DKFZp686B11164; KIAA1999; MGC39830

Clonality

Monoclonal

Isotype

IgG2b,k

Clone Number

1F3

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Specificity

Recognizes human RICTOR.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

195,011 Da

OMIM

609022

3D Structure

ModBase 3D Structure for Q6R327

Immunogen

Partial recombinant protein corresponding to aa1-99 from human RICTOR (NP_689969) with GST tag. MW of the GST tag alone is 26kD.

Conjugate

MaxLight405

Product Categories/Family for anti-RICTOR antibody

Antibodies; Signal Transduction

Applications Tested/Suitable for anti-RICTOR antibody

FLISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

Application Notes for anti-RICTOR antibody

Sandwich FLISA: The detection limit for recombinant GST tagged RICTOR is ~0.03ng/ml as a capture antibody.
Applications are based on unconjugated antibody.

Product References and Citations for anti-RICTOR antibody

1. Nuclear Foxo1 Controls And Integrates Key Signaling Pathways In Hepatocytes. Naimi M, Gautier N, Chaussade C, Valverde AM, Accili D, Van Obberghen E.Endocrinology. 2007 May;148(5):2424-34. Epub 2007 Feb 15.

Other Notes

Small volumes of anti-RICTOR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RICTOR. It may not necessarily be applicable to this product.

NCBI GI #

59891448

NCBI GeneID

253260

NCBI Accession #

NP_689969

UniProt Primary Accession #

Q6R327

UniProt Secondary Accession #

Q68DT5; Q86UB7; Q8N3A0; Q8NCM6; B2RNX0; B7ZMF7

UniProt Related Accession #

Q6R327

GenBank Nucleotide #

NM_152756

NCBI Official Full Name

rapamycin-insensitive companion of mTOR isoform 1

NCBI Official Synonym Full Names

RPTOR independent companion of MTOR, complex 2

NCBI Official Symbol

RICTOR

NCBI Official Synonym Symbols

PIA; AVO3; hAVO3

UniProt Protein Name

Rapamycin-insensitive companion of mTOR

UniProt Synonym Protein Names

AVO3 homolog; hAVO3

Protein Family

Rapamycin-insensitive companion

UniProt Gene Name

RICTOR

UniProt Synonym Gene Names

hAVO3

UniProt Entry Name

RICTR_HUMAN

NCBI Protein Information

rapamycin-insensitive companion of mTOR; AVO3 homolog; RICTOR; TORC2-specific protein AVO3; pianissimo

UniProt Comments for RICTOR

RICTOR: a regulatory binding partner of the kinase mTOR. Part of a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Rictor interacts with Cullin1-Rbx1 to form an E3 ubiquitin ligase complex, and promotes ubiquitination and degradation of SGK1. Shares homology with pianissimo from D. discoidieum, STE20p from S. pombe, and AVO3p from S. cerevisiae.

Protein type: Cell cycle regulation; Ubiquitin conjugating system; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: TORC2 complex; cytosol

Molecular Function: protein binding; ribosome binding; protein kinase binding

Biological Process: epidermal growth factor receptor signaling pathway; TOR signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; regulation of protein kinase B signaling cascade; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; embryonic development; positive regulation of actin filament polymerization; regulation of actin cytoskeleton organization and biogenesis; T cell costimulation; actin cytoskeleton reorganization; innate immune response; positive regulation of endothelial cell proliferation; vascular endothelial growth factor receptor signaling pathway; positive regulation of TOR signaling pathway

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RICTOR antibody

Reference Product	PubMed Publications
MTOR antibody	>345 publications with RICTOR and MTOR
RPTOR antibody	>75 publications with RICTOR and RPTOR
MLST8 antibody	>31 publications with RICTOR and MLST8
AKT1 antibody	>21 publications with RICTOR and AKT1
MAPKAP1 antibody	>14 publications with RICTOR and MAPKAP1
SGK1 antibody	>13 publications with RICTOR and SGK1
PRR5 antibody	>8 publications with RICTOR and PRR5
ILK antibody	>7 publications with RICTOR and ILK
PRKCA antibody	>6 publications with RICTOR and PRKCA

Pathways associated with anti-RICTOR antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
CD28 Co-stimulation Pathway antibodies	CD28 Co-stimulation Pathway Diagram
CD28 Dependent PI3K/Akt Signaling Pathway antibodies	CD28 Dependent PI3K/Akt Signaling Pathway Diagram
CXCR3-mediated Signaling Events Pathway antibodies	CXCR3-mediated Signaling Events Pathway Diagram
CXCR4-mediated Signaling Events Pathway antibodies	CXCR4-mediated Signaling Events Pathway Diagram
Class I PI3K Signaling Events Mediated By Akt Pathway antibodies	Class I PI3K Signaling Events Mediated By Akt Pathway Diagram
Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies	Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
Costimulation By The CD28 Family Pathway antibodies	Costimulation By The CD28 Family Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
DAP12 Signaling Pathway antibodies	DAP12 Signaling Pathway Diagram

Diseases associated with anti-RICTOR antibody

Disease Name	Pubmed Publications
Insulin Resistance Antibodies	>27 publications with RICTOR and Insulin Resistance
Disease Models, Animal Antibodies	>20 publications with RICTOR and Disease Models, Animal
Brain Diseases Antibodies	>19 publications with RICTOR and Brain Diseases
Kidney Diseases Antibodies	>17 publications with RICTOR and Kidney Diseases
Breast Neoplasms Antibodies	>15 publications with RICTOR and Breast Neoplasms
Inflammation Antibodies	>13 publications with RICTOR and Inflammation
Neoplasms, Experimental Antibodies	>12 publications with RICTOR and Neoplasms, Experimental
Adenocarcinoma Antibodies	>12 publications with RICTOR and Adenocarcinoma
Neoplasm Invasiveness Antibodies	>11 publications with RICTOR and Neoplasm Invasiveness
Necrosis Antibodies	>11 publications with RICTOR and Necrosis

Organs/Tissues associated with anti-RICTOR antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>53 publications with RICTOR and Blood
Muscle Antibodies	>44 publications with RICTOR and Muscle
Kidney Antibodies	>27 publications with RICTOR and Kidney
Vascular Antibodies	>23 publications with RICTOR and Vascular
Brain Antibodies	>23 publications with RICTOR and Brain
Liver Antibodies	>21 publications with RICTOR and Liver
Prostate Antibodies	>21 publications with RICTOR and Prostate
Bone Antibodies	>19 publications with RICTOR and Bone
Lung Antibodies	>17 publications with RICTOR and Lung
Bone Marrow Antibodies	>13 publications with RICTOR and Bone Marrow