Protein Kinase C, Alpha/Beta2 (PRKCB) Antibody – Rabbit Polyclonal

PKCB iso2: an AGC kinase of the PKC family. A classical PKC downstream of many mitogenic receptors. Activates the NF-kappaB signaling pathway in B cells after antigen-receptor signaling. Two splice-variant isoforms have been described.

Protein type: Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; EC 2.7.11.13; Protein kinase, Ser/Thr (non-receptor); AGC group; PKC family; Alpha subfamily

Cellular Component: centrosome; membrane; brush border membrane; cytoplasm; plasma membrane; cytosol; nucleus

Molecular Function: protein kinase C activity; zinc ion binding; histone binding; metal ion binding; calcium channel regulator activity; nucleotide binding; protein kinase activity; transferase activity; protein serine/threonine kinase activity; protein binding; ligand-dependent nuclear receptor transcription coactivator activity; androgen receptor binding; protein kinase C binding; transferase activity, transferring phosphorus-containing groups; chromatin binding; kinase activity; ATP binding

Biological Process: response to drug; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; B cell activation; apoptosis; immune system process; positive regulation of B cell receptor signaling pathway; negative regulation of insulin receptor signaling pathway; chromatin modification; regulation of dopamine secretion; protein amino acid phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; activation of NF-kappaB transcription factor; cellular calcium ion homeostasis; regulation of transcription from RNA polymerase II promoter; B cell receptor signaling pathway; positive regulation of angiogenesis; regulation of transcription, DNA-dependent; regulation of growth; calcium ion transport; response to hypoxia; phosphorylation