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Renin-1 (REN1) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS619395

Mouse Renin is a secreted, 42-47kD glycosylated member of the peptidase A1 family. It is an aspartyl protease that cleaves angiotensinogen to form angiotensin I. In mouse, there are two genes that code for Renin. One is in the submandibular gland and the… More details

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Product Overview

Online Datasheet in PDF
Product Name
Renin-1 (Ren1), Polyclonal Antibody
Full Product Name
Renin-1 (Angiotensinogenase, Kidney Renin) (Biotin)
Product Gene Name
anti-Ren1 antibody
Product Synonym Names
Anti -Renin-1 (Angiotensinogenase, Kidney Renin) (Biotin)
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Mouse
Form/Format
Supplied as a lyophilized powder in PBS, BSA. Reconstitute with sterile Tris-buffered saline, pH7.3, 0.1% BSA. Labeled with Biotin.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes mouse Renin 1. Species sequence homology: human (70%), rat (85%).
Preparation and Storage
Lyophilized powder may be stored at -20 degree C for short-term only. Reconstitute with sterile 40-50% glycerol, aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
44,343 Da
Chromosome Location
Chromosome: 1; NC_000067.5 (135247251..135256894). Location: 1 E4; 1 69.9 cM
3D Structure
ModBase 3D Structure for P06281
Immunogen
NS0-derived recombinant mouse Renin 1.

Product Categories/Family for anti-Ren1 antibody

Antibodies; Abs to Angiotensin; Angiotensinogen
Applications Tested/Suitable for anti-Ren1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-Ren1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 0.1-0.4ug/ml
Western Blot: 0.1-0.2ug/ml

Other Notes

Small volumes of anti-Ren1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ren1 purchase

MBS619395 is an antibody targeting Ren1. Also known as Renin-1 (Angiotensinogenase, Kidney Renin) (Biotin). Reactive in Mouse. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for Ren1. It may not necessarily be applicable to this product.

NCBI GI #
13676837
NCBI GeneID
19701
NCBI Accession #
NP_112469.1
UniProt Primary Accession #
P06281
UniProt Secondary Accession #
P97911; Q543E5; Q62153; Q62154
UniProt Related Accession #
P06281; Q9R259
GenBank Nucleotide #
NM_031192.3
NCBI Official Full Name
renin-1
NCBI Official Synonym Full Names
renin 1 structural
NCBI Official Symbol
Ren1
NCBI Official Synonym Symbols
Ren; Rnr; Rn-1; Ren-1; Ren-A; Ren1c; Ren1d; D19352
UniProt Protein Name
Renin-1
UniProt Synonym Protein Names
Angiotensinogenase; Kidney renin
Protein Family
Renin
UniProt Gene Name
Ren1
UniProt Synonym Gene Names
Ren; Ren-1
UniProt Entry Name
RENI1_MOUSE
NCBI Protein Information
renin-1; renin b; kidney renin; aspartyl-protease; OTTMUSP00000024128; angiotensinogenase

UniProt Comments for Ren1

REN: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Interacts with ATP6AP2. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Protease; Secreted; EC 3.4.23.15

Cellular Component: extracellular space; membrane; cytoplasm; extracellular region; intracellular

Molecular Function: peptidase activity; insulin-like growth factor receptor binding; hydrolase activity; endopeptidase activity; aspartic-type endopeptidase activity; receptor binding

Biological Process: response to drug; response to cAMP; hormone-mediated signaling; establishment of blood-nerve barrier; drinking behavior; renin-angiotensin regulation of aldosterone production; cell maturation; proteolysis; angiotensin maturation; response to organic substance; regulation of blood pressure; regulation of MAPKKK cascade; renin-angiotensin regulation of blood volume; kidney development
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Research Articles on Ren1

1. In addition to its direct effect on renin gene transcription, PPARgamma "sensitizes" renin gene to cAMP via trans-activation of AC6 gene.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Ren1 antibody

 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram

Diseases associated with anti-Ren1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with Ren1 and Neoplasms
 Cardiovascular Diseases Antibodies  >2 publications with Ren1 and Cardiovascular Diseases
 Hypertension Antibodies  >2 publications with Ren1 and Hypertension
 Body Weight Changes Antibodies  >1 publications with Ren1 and Body Weight Changes
 Gonadal Disorders Antibodies  >1 publications with Ren1 and Gonadal Disorders
 Kidney Neoplasms Antibodies  >1 publications with Ren1 and Kidney Neoplasms
 Fibrosis Antibodies  >1 publications with Ren1 and Fibrosis

Organs/Tissues associated with anti-Ren1 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >13 publications with Ren1 and Kidney
 Salivary Gland Antibodies  >3 publications with Ren1 and Salivary Gland
 Liver Antibodies  >1 publications with Ren1 and Liver
 Brain Antibodies  >1 publications with Ren1 and Brain
 Testis Antibodies  >1 publications with Ren1 and Testis
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