Receptor Interacting Protein 140 (NRIP1) Antibody – Goat Polyclonal

RIP140: Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Interacts with RARA and RXRB homodimers and RARA/RXRB heterodimers in the presence of ligand. Interacts with HDAC1 and HDAC3 via its N-terminal domain. Interacts with NR2C1 (sumoylated form and via the ligand-binding domain); the interaction results in promoting the repressor activity of NR2C1. Interacts with CTBP1, CTBP2, ESR1, HDAC1, HDAC2, HDAC5, HDAC6, NR2C2, NR3C1, NR3C2, YWHAH, JUN and FOS. Found in a complex with both NR3C1 and YWHAH. Interacts with ZNF366.

Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Cellular Component: nucleoplasm; histone deacetylase complex; nucleolus; nuclear speck; cell junction; nucleus

Molecular Function: retinoid X receptor binding; protein binding; retinoic acid receptor binding; histone deacetylase binding; transcription coactivator activity; transcription cofactor activity; estrogen receptor binding; transcription corepressor activity; receptor binding; glucocorticoid receptor binding; nuclear hormone receptor binding

Biological Process: ovulation; regulation of transcription from RNA polymerase II promoter; sequestering of lipid; regulation of transcription, DNA-dependent; transcription, DNA-dependent; rhythmic process; positive regulation of transcription from RNA polymerase II promoter; circadian regulation of gene expression; negative regulation of transcription from RNA polymerase II promoter; ovarian follicle rupture