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RBBP5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS619518

Retinoblastoma binding protein 5 (RbBP5) belongs to a highly conserved subfamily of WD-repeat proteins and it is also a subunit of a human Set1-like histone methyltransferase (HMT) complex. The encoded RbBP 5protein interacts preferentially with the… More details

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Product Overview

Online Datasheet in PDF
Product Name
RbBP5, Polyclonal Antibody
Full Product Name
RbBP5 (Retinoblastoma Binding Protein 5, RbBP-5, RBQ3, Retinoblastoma Binding Protein RBQ3, SWD1, SWD1 Set1c WD40 Repeat Protein Homolog)
Product Gene Name
anti-RBBP5 antibody
Product Synonym Names
Anti -RbBP5 (Retinoblastoma Binding Protein 5, RbBP-5, RBQ3, Retinoblastoma Binding Protein RBQ3, SWD1, SWD1 Set1c WD40 Repeat Protein Homolog)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Specificity
Recognizes mouse RbBP5 at~59kD. Species crossreactivity: human and rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
59,153 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (205055270..205091150, complement). Location: 1q32
OMIM
600697
3D Structure
ModBase 3D Structure for Q15291
Immunogen
Synthetic peptide surrounding amino acid 504 of mouse RbBP5.

Product Categories/Family for anti-RBBP5 antibody

Antibodies; Abs to Retinoblastoma Proteins
Applications Tested/Suitable for anti-RBBP5 antibody
Western Blot (WB)
Application Notes for anti-RBBP5 antibody
Suitable for use in Western Blot.
Dilution: Western Blot: 0.5-4ug/ml

Western Blot (WB) of anti-RBBP5 antibody

Western blot analysis of RbBP5 in Jurkat cell lysate (Lane 1) and in 3T3 cell lysate (Lane 2).
Rabbit Anti-RBBP5 Polyclonal Antibody – Cat# MBS619518

Other Notes

Small volumes of anti-RBBP5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RBBP5 purchase

MBS619518 is an antibody targeting RBBP5. Also known as RbBP5 (Retinoblastoma Binding Protein 5, RbBP-5, RBQ3, Retinoblastoma Binding Protein RBQ3, SWD1, SWD1 Set1c WD40 Repeat Protein Homolog). Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RBBP5. It may not necessarily be applicable to this product.

NCBI GI #
300796343
NCBI GeneID
5929
NCBI Accession #
NP_001180202.1
UniProt Primary Accession #
Q15291
UniProt Secondary Accession #
Q7Z6D8; Q8NDZ7; A8K272
UniProt Related Accession #
Q15291
GenBank Nucleotide #
NM_001193273.1
NCBI Official Full Name
retinoblastoma-binding protein 5 isoform 3
NCBI Official Synonym Full Names
retinoblastoma binding protein 5
NCBI Official Symbol
RBBP5
NCBI Official Synonym Symbols
RBQ3; SWD1
UniProt Protein Name
Retinoblastoma-binding protein 5
UniProt Synonym Protein Names
Retinoblastoma-binding protein RBQ-3
Protein Family
Retinoblastoma-binding protein
UniProt Gene Name
RBBP5
UniProt Synonym Gene Names
RBQ3
UniProt Entry Name
RBBP5_HUMAN
NCBI Protein Information
retinoblastoma-binding protein 5; RBBP-5; OTTHUMP00000035177; OTTHUMP00000035178; retinoblastoma-binding protein RBQ-3; SWD1, Set1c WD40 repeat protein, homolog

NCBI Summary for RBBP5

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq]
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UniProt Comments for RBBP5

RBBP5: As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Core component of several methyltransferase-containing complexes including MLL1/MLL, ASCOM, MLL2/MLL3 and MLL3/MLL4. Each complex is at least composed of ASH2L, RBBP5, DPY30, WDR5, one or more specific histone methyltransferases (MLL, MLL2, MLL3 and MLL4), and the facultative components C16orf53/PA1, C17orf49, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with WDR5 and ASH2L; the interaction is direct. Interacts with WDR82 and SETD1A. Ubiquitously expressed. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: nucleoplasm; histone methyltransferase complex; nucleolus; nucleus

Molecular Function: protein binding; histone lysine N-methyltransferase activity (H3-K4 specific); methylated histone residue binding

Biological Process: establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription, DNA-dependent; response to estrogen stimulus; histone H3-K4 methylation; response to DNA damage stimulus
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Research Articles on RBBP5

1. MLL1 SET domain make direct contacts with the substrates and contribute to the formation of a joint catalytic center.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RBBP5 antibody

 Reference Product  PubMed Publications
 MLL antibody  >17 publications with RBBP5 and MLL
 MEN1 antibody  >4 publications with RBBP5 and MEN1

Diseases associated with anti-RBBP5 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with RBBP5 and Neoplasms
 Neuroectodermal Tumors Antibodies  >2 publications with RBBP5 and Neuroectodermal Tumors
 Hyperplasia Antibodies  >1 publications with RBBP5 and Hyperplasia

Organs/Tissues associated with anti-RBBP5 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with RBBP5 and Blood
 Embryonic Tissue Antibodies  >2 publications with RBBP5 and Embryonic Tissue
 Bone Marrow Antibodies  >1 publications with RBBP5 and Bone Marrow
 Bone Antibodies  >1 publications with RBBP5 and Bone
 Connective Tissue Antibodies  >1 publications with RBBP5 and Connective Tissue
 Kidney Antibodies  >1 publications with RBBP5 and Kidney
 Brain Antibodies  >1 publications with RBBP5 and Brain
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