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KCNQ5 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS619537

This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form… More details

$610 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Kv7.5 (KCNQ5), Polyclonal Antibody
Full Product Name
Kv7.5 (KCNQ5, Potassium Voltage-gated Channel, KQT-like Subfamily, Member 5, KQT-like 5, Potassium Channel Subunit alpha KvLQT5, Potassium Channel Protein, Voltage-gated Potassium Channel Subunit Kv7.5)
Product Gene Name
anti-KCNQ5 antibody
Product Synonym Names
Anti -Kv7.5 (KCNQ5, Potassium Voltage-gated Channel, KQT-like Subfamily, Member 5, KQT-like 5, Potassium Channel Subunit alpha KvLQT5, Potassium Channel Protein, Voltage-gated Potassium Channel Subunit Kv7.5)
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Human
Form/Format
Supplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human KCNQ5. Species sequence homology: mouse, rat, pig, canine.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 monthsat -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
102,179 Da
Chromosome Location
Chromosome: 6; NC_000006.11 (73331571..73908574). Location: 6q14
OMIM
607357
3D Structure
ModBase 3D Structure for Q9NR82
Immunogen
Synthetic peptide, C-ESTDALSLPHVKLK, from the C-Terminus of human KCNQ5.
Positive Control
Human Skeletal Muscle lysates

Product Categories/Family for anti-KCNQ5 antibody

Antibodies; Abs to Ion Channel
Applications Tested/Suitable for anti-KCNQ5 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-KCNQ5 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:64000
Western Blot: 0.3 ug/ml

Other Notes

Small volumes of anti-KCNQ5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KCNQ5 purchase

MBS619537 is an antibody targeting KCNQ5. Also known as Kv7.5 (KCNQ5, Potassium Voltage-gated Channel, KQT-like Subfamily, Member 5, KQT-like 5, Potassium Channel Subunit alpha KvLQT5, Potassium Channel Protein, Voltage-gated Potassium Channel Subunit Kv7.5). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNQ5. It may not necessarily be applicable to this product.

NCBI GI #
219517889
NCBI GeneID
56479
NCBI Accession #
AAI43555.1
UniProt Primary Accession #
Q9NR82
UniProt Secondary Accession #
Q17RE1; Q5VVP3; Q86W40; Q9NRN0; Q9NYA6; B4DS33; B5MC83; B7ZL37; F5GZV0
UniProt Related Accession #
Q9NR82
NCBI Official Full Name
KCNQ5 protein
NCBI Official Synonym Full Names
potassium voltage-gated channel, KQT-like subfamily, member 5
NCBI Official Symbol
KCNQ5
NCBI Official Synonym Symbols
Kv7.5
UniProt Protein Name
Potassium voltage-gated channel subfamily KQT member 5
UniProt Synonym Protein Names
KQT-like 5; Potassium channel subunit alpha KvLQT5; Voltage-gated potassium channel subunit Kv7.5
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
KCNQ5
UniProt Entry Name
KCNQ5_HUMAN
NCBI Protein Information
potassium voltage-gated channel subfamily KQT member 5; KQT-like 5; potassium channel protein; potassium channel subunit alpha KvLQT5; voltage-gated potassium channel subunit Kv7.5

UniProt Comments for KCNQ5

Kv7.5: Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Channel, potassium; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6q14

Cellular Component: voltage-gated potassium channel complex; integral to membrane; plasma membrane

Molecular Function: delayed rectifier potassium channel activity; inward rectifier potassium channel activity

Biological Process: synaptic transmission; protein complex assembly
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Research Articles on KCNQ5

1. characterized the cell-type specific spatial organization of the kcnq5 gene locus mediated by CTCF in detail using chromosome conformation capture (3C) and 3C-derived techniques

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KCNQ5 antibody

 Reference Product  PubMed Publications
 KCNQ3 antibody  >52 publications with KCNQ5 and KCNQ3

Pathways associated with anti-KCNQ5 antibody

 Products by Pathway  Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram

Diseases associated with anti-KCNQ5 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >14 publications with KCNQ5 and Nervous System Diseases
 Pain Antibodies  >8 publications with KCNQ5 and Pain
 Heart Diseases Antibodies  >3 publications with KCNQ5 and Heart Diseases
 Disease Models, Animal Antibodies  >2 publications with KCNQ5 and Disease Models, Animal
 Liver Diseases Antibodies  >1 publications with KCNQ5 and Liver Diseases
 Lung Diseases Antibodies  >1 publications with KCNQ5 and Lung Diseases
 Fibrosis Antibodies  >1 publications with KCNQ5 and Fibrosis
 Myopia Antibodies  >1 publications with KCNQ5 and Myopia

Organs/Tissues associated with anti-KCNQ5 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >28 publications with KCNQ5 and Brain
 Liver Antibodies  >3 publications with KCNQ5 and Liver
 Eye Antibodies  >3 publications with KCNQ5 and Eye
 Lung Antibodies  >2 publications with KCNQ5 and Lung
 Bone Antibodies  >1 publications with KCNQ5 and Bone
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