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ACSL1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS619678

Mammalian long-chain acyl-CoA synthetase (ACSL) catalyzes the ligation of the fatty acid to CoA to form fatty acyl-CoA in a two-step reaction (1). Five isoforms of ACSL have been identified (1). These isoforms have different substrate preferences and… More details

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Product Overview

Online Datasheet in PDF
Product Name
ACSL1, Polyclonal Antibody
Full Product Name
ACSL1 (Acyl-CoA Synthetase Long-chain Family Member 1, Acyl-CoA Synthetase 1, ACS1, FACL1, FACL2, LACS, Long-chain-fatty-acid-CoA Ligase 1, Long-chain Fatty Acid-CoA Ligase 2, Long-chain Acyl-CoA Synthetase 1, LACS 1, LACS1, Long-chain Acyl-CoA Synthetase
Product Gene Name
anti-ACSL1 antibody
Product Synonym Names
Anti -ACSL1 (Acyl-CoA Synthetase Long-chain Family Member 1, Acyl-CoA Synthetase 1, ACS1, FACL1, FACL2, LACS, Long-chain-fatty-acid-CoA Ligase 1, Long-chain Fatty Acid-CoA Ligase 2, Long-chain Acyl-CoA Synthetase 1, LACS 1, LACS1, Long-chain Acyl-CoA Synthetase
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM NaCl, 0.1mg/ml BSA, 50% glycerol.
Purity/Purification
Affinity Purified
Purified by peptide affinity chromatography.
Specificity
Recognizes endogenous levels of human total ACSL1 protein. Species Crossreactivity: Mouse and rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
77,943 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (185676749..185747215, complement). Location: 4q35
OMIM
152425
3D Structure
ModBase 3D Structure for P33121
Immunogen
Synthetic peptide derived from a sequence of human ACSL1.

Product Categories/Family for anti-ACSL1 antibody

Antibodies; Abs to Enzymes; Synthetase
Applications Tested/Suitable for anti-ACSL1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ACSL1 antibody
Suitable for use in Western Blot and Immunohistochemistry (Paraffin).
Dilution: Western Blot: 1:1000
Immunohistochemistry: 1:25

Western Blot (WB) of anti-ACSL1 antibody

Western blot analysis of extracts from various cell types using A0195-90.
Rabbit Anti-ACSL1 Polyclonal Antibody – Cat# MBS619678

Immunohistochemistry (IHC) of anti-ACSL1 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma using A0195-90.
Rabbit Anti-ACSL1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS619678

Immunohistochemistry (IHC) of anti-ACSL1 antibody

Immunohistochemical analysis of paraffin-embedded human lung carcinoma using A0195-90.
Rabbit Anti-ACSL1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS619678

Immunohistochemistry (IHC) of anti-ACSL1 antibody

Immunohistochemical analysis of paraffin-embedded human lymphoma using A0195-90.
Rabbit Anti-ACSL1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS619678

Other Notes

Small volumes of anti-ACSL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACSL1 purchase

MBS619678 is an antibody targeting ACSL1. Also known as ACSL1 (Acyl-CoA Synthetase Long-chain Family Member 1, Acyl-CoA Synthetase 1, ACS1, FACL1, FACL2, LACS, Long-chain-fatty-acid-CoA Ligase 1, Long-chain Fatty Acid-CoA Ligase 2, Long-chain Acyl-CoA Synthetase 1, LACS 1, LACS1, Long-chain Acyl-CoA Synthetase. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ACSL1. It may not necessarily be applicable to this product.

NCBI GI #
20072835
NCBI GeneID
2180
UniProt Primary Accession #
P33121
UniProt Secondary Accession #
P41215; Q8N8V7; Q8TA99; D3DP57
UniProt Related Accession #
P33121; Q108N1; Q108N2
NCBI Official Full Name
ACSL1 protein
NCBI Official Synonym Full Names
acyl-CoA synthetase long-chain family member 1
NCBI Official Symbol
ACSL1
NCBI Official Synonym Symbols
ACS1; LACS; FACL1; FACL2; LACS1; LACS2
UniProt Protein Name
Long-chain-fatty-acid--CoA ligase 1
UniProt Synonym Protein Names
Acyl-CoA synthetase 1; ACS1; Long-chain acyl-CoA synthetase 1; LACS 1; Long-chain acyl-CoA synthetase 2; LACS 2; Long-chain fatty acid-CoA ligase 2; Palmitoyl-CoA ligase 1; Palmitoyl-CoA ligase 2
Protein Family
Long-chain-fatty-acid--CoA ligase
UniProt Gene Name
ACSL1
UniProt Synonym Gene Names
FACL1; FACL2; LACS; LACS1; LACS2
UniProt Entry Name
ACSL1_HUMAN
NCBI Protein Information
long-chain-fatty-acid--CoA ligase 1; LACS 1; LACS 2; OTTHUMP00000218456; OTTHUMP00000218457; OTTHUMP00000218460; OTTHUMP00000218461; OTTHUMP00000218462; OTTHUMP00000218465; acyl-CoA synthetase 1; palmitoyl-CoA ligase 1; palmitoyl-CoA ligase 2; paltimoyl-CoA ligase 1; lignoceroyl-CoA synthase; long-chain acyl-CoA synthetase 1; long-chain acyl-CoA synthetase 2; long-chain fatty acid-CoA ligase 2; long-chain fatty-acid-coenzyme A ligase 1; fatty-acid-Coenzyme A ligase, long-chain 1; fatty-acid-Coenzyme A ligase, long-chain 2

NCBI Summary for ACSL1

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. [provided by RefSeq]
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UniProt Comments for ACSL1

ACSL1: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate. Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.2.1.3; Ligase; Membrane protein, integral; Lipid Metabolism - fatty acid

Chromosomal Location of Human Ortholog: 4q35.1

Cellular Component: peroxisomal membrane; mitochondrial outer membrane; endoplasmic reticulum membrane; membrane; mitochondrion; plasma membrane; integral to membrane

Molecular Function: ATP binding; long-chain-fatty-acid-CoA ligase activity

Biological Process: response to drug; response to oleate; unsaturated fatty acid metabolic process; lipid biosynthetic process; linoleic acid metabolic process; adiponectin-mediated signaling pathway; triacylglycerol biosynthetic process; cellular lipid metabolic process; long-chain fatty acid metabolic process; response to organic cyclic substance; response to nutrient; xenobiotic catabolic process
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Research Articles on ACSL1

1. Data show that ACSL1 rs9997745 polymorphism influences metabolic syndrome risk, most likely via disturbances in fatty acid metabolism, which was modulated by dietary fat consumption, particularly PUFA intake, suggesting novel gene-nutrient interactions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ACSL1 antibody

 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Fatty Acid Biosynthesis Pathway antibodies  Fatty Acid Biosynthesis Pathway Diagram
 Fatty Acyl-CoA Biosynthesis Pathway antibodies  Fatty Acyl-CoA Biosynthesis Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram

Diseases associated with anti-ACSL1 antibody

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >10 publications with ACSL1 and Fatty Liver
 Insulin Resistance Antibodies  >6 publications with ACSL1 and Insulin Resistance
 Obesity Antibodies  >5 publications with ACSL1 and Obesity
 Liver Diseases Antibodies  >5 publications with ACSL1 and Liver Diseases
 Hepatitis Antibodies  >3 publications with ACSL1 and Hepatitis
 Drug Toxicity Antibodies  >2 publications with ACSL1 and Drug Toxicity
 Neoplasms Antibodies  >2 publications with ACSL1 and Neoplasms
 Diabetes Mellitus Antibodies  >1 publications with ACSL1 and Diabetes Mellitus
 Adenocarcinoma Antibodies  >1 publications with ACSL1 and Adenocarcinoma
 Liver Failure, Acute Antibodies  >1 publications with ACSL1 and Liver Failure, Acute

Organs/Tissues associated with anti-ACSL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >16 publications with ACSL1 and Liver
 Blood Antibodies  >8 publications with ACSL1 and Blood
 Muscle Antibodies  >7 publications with ACSL1 and Muscle
 Adipose Tissue Antibodies  >5 publications with ACSL1 and Adipose Tissue
 Heart Antibodies  >5 publications with ACSL1 and Heart
 Connective Tissue Antibodies  >3 publications with ACSL1 and Connective Tissue
 Brain Antibodies  >3 publications with ACSL1 and Brain
 Placenta Antibodies  >2 publications with ACSL1 and Placenta
 Mammary Gland Antibodies  >2 publications with ACSL1 and Mammary Gland
 Kidney Antibodies  >1 publications with ACSL1 and Kidney
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