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Nucleus Accumbens-Associated Protein 1 (NACC1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS619787

NAC1 or nuclear accumbens-1 is a nuclear factor that belongs to the POZ/BTB (Pox virus and zinc finger/bric-a-brac tramtrack broad complex) domain family. Also known as BTBD14B, it was originally identified in a unique neuronal forebrain structure responsible… More details

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Product Overview

Online Datasheet in PDF
Product Name
Nucleus accumbens-associated protein 1 (NACC1), Polyclonal Antibody
Full Product Name
Nucleus accumbens-associated protein 1 (NACC1, Nucleus accumbens associated 1, BEN and BTB (POZ) domain containing, BEND8, BTB/POZ domain-containing protein 14B, BTBD14B, FLJ37383, NAC1, NAC-1)
Product Gene Name
anti-NACC1 antibody
Product Synonym Names
Anti -Nucleus accumbens-associated protein 1 (NACC1, Nucleus accumbens associated 1, BEN and BTB (POZ) domain containing, BEND8, BTB/POZ domain-containing protein 14B, BTBD14B, FLJ37383, NAC1, NAC-1)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Supplied in 10mM sodium HEPES (pH 7.5), 150mM NaCl, 100ug/ml BSA and 50% glycerol.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes mouse NAC1. Species crossreactivity
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
57,258 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (13229109..13251959). Location: 19p13.2
OMIM
610672
3D Structure
ModBase 3D Structure for Q96RE7
Immunogen
Synthetic peptide corresponding to the amino acid sequence surrounding Ala321 of human NAC1 protein (KLH-coupled).

Product Categories/Family for anti-NACC1 antibody

Antibodies; Abs to Transcription Factors
Applications Tested/Suitable for anti-NACC1 antibody
Western Blot (WB)
Application Notes for anti-NACC1 antibody
Suitable for use in Western Blot.
Dilution: Western Blot: 1:1000. Incubate membrane with diluted antibody in 5% w/v BSA, 1X TBS, 0.1%
Tween-20 at 4 degree C with gentle shaking, overnight.

Western Blot (WB) of anti-NACC1 antibody

Western blot analysis of extracts from adult mouse brain using MBS619787.
Rabbit Anti-NACC1 Polyclonal Antibody – Cat# MBS619787

Western Blot (WB) of anti-NACC1 antibody

Western blot analysis of extracts from fetal and adult rat brain using MBS619787.
Rabbit Anti-NACC1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS619787

Other Notes

Small volumes of anti-NACC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NACC1 purchase

MBS619787 is an antibody targeting NACC1. Also known as Nucleus accumbens-associated protein 1 (NACC1, Nucleus accumbens associated 1, BEN and BTB (POZ) domain containing, BEND8, BTB/POZ domain-containing protein 14B, BTBD14B, FLJ37383, NAC1, NAC-1). Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NACC1. It may not necessarily be applicable to this product.

NCBI GI #
16418383
NCBI GeneID
112939
NCBI Accession #
NP_443108.1
UniProt Primary Accession #
Q96RE7
UniProt Related Accession #
Q96RE7
GenBank Nucleotide #
NM_052876.2
NCBI Official Full Name
nucleus accumbens-associated protein 1
NCBI Official Synonym Full Names
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
NCBI Official Symbol
NACC1
NCBI Official Synonym Symbols
NAC1; BEND8; NAC-1; BTBD14B; FLJ37383
UniProt Protein Name
Nucleus accumbens-associated protein 1
UniProt Synonym Protein Names
BTB/POZ domain-containing protein 14B
Protein Family
Nucleus accumbens-associated protein
UniProt Gene Name
NACC1
UniProt Synonym Gene Names
BTBD14B; NAC1
UniProt Entry Name
NACC1_HUMAN
NCBI Protein Information
nucleus accumbens-associated protein 1; BEN domain containing 8; transcriptional repressor NAC1; BTB (POZ) domain containing 14B; BTB/POZ domain-containing protein 14B

NCBI Summary for NACC1

Members of the BTB/POZ family of transcriptional regulators, including BTBD14B, contain a conserved motif in the N-terminal region critical for protein-protein interactions and assembly of high molecular mass complexes (Korutla et al., 2002 [PubMed 11906783]).[supplied by OMIM]

UniProt Comments for NACC1

NAC1: Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. Homooligomer; mediated by the BTB domain. Interacts with HDAC3 and HDAC4. Interacts (via BTB domain) with CUL3, PSMD7 AND RCOR1. Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: nucleoplasm; nuclear body; intracellular membrane-bound organelle; cytoplasm; cell junction; nucleus

Biological Process: transcription, DNA-dependent; positive regulation of cell proliferation; negative regulation of transcription, DNA-dependent; protein homooligomerization
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Research Articles on NACC1

1. These results indicate that a cell cycle-dependent regulatory mechanism controls NAC1 body formation in the nucleus and suggest that NAC1 body dynamics are associated with mitosis or cytokinesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NACC1 antibody

 Reference Product  PubMed Publications
 HDAC4 antibody  >2 publications with NACC1 and HDAC4

Diseases associated with anti-NACC1 antibody

 Disease Name  Pubmed Publications
 Substance-Related Disorders Antibodies  >3 publications with NACC1 and Substance-Related Disorders
 Psychoses, Substance-Induced Antibodies  >1 publications with NACC1 and Psychoses, Substance-Induced
 Psychotic Disorders Antibodies  >1 publications with NACC1 and Psychotic Disorders
 Drug Toxicity Antibodies  >1 publications with NACC1 and Drug Toxicity

Organs/Tissues associated with anti-NACC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >1 publications with NACC1 and Lymph Node
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