• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Cytochrome P450 46a1 (CYP46A1) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS619866

CYP46A1 converts cholesterol into the biologically active oxysterol and 24(S)-hydroxycholesterol, in the first step of the enzymatic degradation of cholesterol in the brain. CYP46A1 is also thought to play a role in the metabolism of neurosteroids and drugs… More details

$760 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cytochrome P450 46A1 (CYP46A1), Polyclonal Antibody
Full Product Name
Cytochrome P450 46A1, CT (CYP46A1, Cholesterol 24-hydroxylase, CH24H, CYP46)
Product Gene Name
Product Synonym Names
Anti -Cytochrome P450 46A1, CT (CYP46A1, Cholesterol 24-hydroxylase, CH24H, CYP46)
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Human
Form/Format
Supplied as a liquid, 0.09% sodium azide.
Purity/Purification
Serum
Serum
Specificity
Recognizes human cholesterol 24-hydroxylase (CYP46A1).
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
56,821 Da
Chromosome Location
Chromosome: 14; NC_000014.8 (100150755..100193638). Location: 14q32.1
OMIM
604087
3D Structure
ModBase 3D Structure for Q9Y6A2
Immunogen
Synthetic peptide corresponding to aa sequence 254-270 of human cholesterol 24-hydroxylase protein.
Applications Tested/Suitable for anti-CYP46A1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CYP46A1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:15,000
Western Blot: 1:3,000

Other Notes

Small volumes of anti-CYP46A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CYP46A1 purchase

MBS619866 is an antibody targeting CYP46A1. Also known as Cytochrome P450 46A1, CT (CYP46A1, Cholesterol 24-hydroxylase, CH24H, CYP46). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for CYP46A1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
cholesterol 24-hydroxylase
NCBI Official Synonym Full Names
cytochrome P450, family 46, subfamily A, polypeptide 1
NCBI Official Symbol
CYP46A1
NCBI Official Synonym Symbols
CP46; CYP46
UniProt Protein Name
Cholesterol 24-hydroxylase
UniProt Synonym Protein Names
Cytochrome P450 46A1
UniProt Gene Name
CYP46A1
UniProt Synonym Gene Names
CYP46; CH24H
UniProt Entry Name
CP46A_HUMAN
NCBI Protein Information
cholesterol 24-hydroxylase; CH24H; cytochrome P450 46A1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)

NCBI Summary for CYP46A1

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for CYP46A1

CYP46A1: Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Belongs to the cytochrome P450 family.

Protein type: Oxidoreductase; Lipid Metabolism - primary bile acid biosynthesis; EC 1.14.13.98; Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane

Molecular Function: iron ion binding; cholesterol 24-hydroxylase activity; heme binding; steroid hydroxylase activity

Biological Process: nervous system development; bile acid biosynthetic process; bile acid metabolic process; xenobiotic metabolic process; cholesterol catabolic process; sterol metabolic process
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000