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SFRP2 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS619998

MBS619998 is an antibody targeting SFRP2. Also known as SFRP2 (Secreted Frizzled-related Protein 2, FRP-2, SARP1, SDF-5, Secreted Apoptosis Related Protein 1). Reactive in Canine, Human, Mouse, Rat. Host: Goat. More details

$835 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SFRP2, Polyclonal Antibody
Full Product Name
SFRP2 (Secreted Frizzled-related Protein 2, FRP-2, SARP1, SDF-5, Secreted Apoptosis Related Protein 1)
Product Gene Name
anti-SFRP2 antibody
Product Synonym Names
Anti -SFRP2 (Secreted Frizzled-related Protein 2, FRP-2, SARP1, SDF-5, Secreted Apoptosis Related Protein 1)
Clonality
Polyclonal
Host
Goat
Species Reactivity
Canine, Human, Mouse, Rat
Form/Format
Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Specificity
Recognizes human SFRP2. Species Crossreactivity: mouse, rat, canine.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
33,490 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (154701742..154710228, complement). Location: 4q31.3
OMIM
604157
3D Structure
ModBase 3D Structure for Q96HF1
Immunogen
A synthetic peptide from the C-terminus of aa-KRWQKGQREFKR.

Product Categories/Family for anti-SFRP2 antibody

Antibodies; Abs to Wnt Proteins
Applications Tested/Suitable for anti-SFRP2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-SFRP2 antibody
Suitable for use in ELISA, Western Blot.
Dilution: Peptide ELISA: 1:32,000.
Western Blot: 1-3ug/ml. Approx 38kD band observed in Human Duodenum lysates (calculated MW of 33.5kD according to NP_003004.1). Optimal dilutions to be determined by the researcher.

Chemiluminescence of anti-SFRP2 antibody

MBS619998(0.1ug/ml) staining of Human Duodenum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-SFRP2 Polyclonal Antibody – Cat# MBS619998

Other Notes

Small volumes of anti-SFRP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SFRP2. It may not necessarily be applicable to this product.

NCBI GI #
48475052
NCBI GeneID
6423
NCBI Accession #
NP_003004.1
UniProt Primary Accession #
Q96HF1
UniProt Secondary Accession #
O14778; Q9HAP5; B3KQR2
UniProt Related Accession #
Q96HF1
GenBank Nucleotide #
NM_003013.2
NCBI Official Full Name
secreted frizzled-related protein 2
NCBI Official Synonym Full Names
secreted frizzled-related protein 2
NCBI Official Symbol
SFRP2
NCBI Official Synonym Symbols
FRP-2; SARP1; SDF-5
UniProt Protein Name
Secreted frizzled-related protein 2
UniProt Synonym Protein Names
Secreted apoptosis-related protein 1
Protein Family
Secreted frizzled-related protein
UniProt Gene Name
SFRP2
UniProt Synonym Gene Names
FRP2; SARP1
UniProt Entry Name
SFRP2_HUMAN
NCBI Protein Information
secreted frizzled-related protein 2; SARP-1; sFRP-2; OTTHUMP00000220373; secreted apoptosis related protein 1; secreted apoptosis-related protein 1

NCBI Summary for SFRP2

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq]
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UniProt Comments for SFRP2

SFRP2: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis. Belongs to the secreted frizzled-related protein (sFRP) family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q31.3

Cellular Component: extracellular matrix; extracellular space; integral to membrane

Molecular Function: G-protein coupled receptor activity; integrin binding; Wnt-protein binding; Wnt receptor activity; fibronectin binding; receptor agonist activity

Biological Process: convergent extension involved in axis elongation; collagen fibril organization; negative regulation of Wnt receptor signaling pathway; positive regulation of apoptosis; negative regulation of caspase activity; negative regulation of BMP signaling pathway; negative regulation of cell proliferation; negative regulation of mesodermal cell fate specification; cell-cell signaling; positive regulation of cell proliferation; negative regulation of cell migration; response to nutrient; negative regulation of epithelial cell proliferation; response to drug; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of JNK activity; male gonad development; positive regulation of cell adhesion mediated by integrin; digestive tract morphogenesis; chondrocyte development; positive regulation of peptidyl-serine phosphorylation; positive regulation of cell growth; patterning of blood vessels; positive regulation of osteoblast differentiation; positive regulation of angiogenesis; neural tube closure; cellular response to extracellular stimulus; positive regulation of fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; negative regulation of cell growth; negative regulation of transcription, DNA-dependent
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Research Articles on SFRP2

1. serum SFRP2 methylation status represents a promising, non-invasive marker for colorectal carcinoma detection and staging

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SFRP2 antibody

 Reference Product  PubMed Publications
 WNT4 antibody  >9 publications with SFRP2 and WNT4
 WNT1 antibody  >6 publications with SFRP2 and WNT1
 PAX2 antibody  >2 publications with SFRP2 and PAX2

Pathways associated with anti-SFRP2 antibody

 Products by Pathway  Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram

Diseases associated with anti-SFRP2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >90 publications with SFRP2 and Neoplasms
 Carcinoma Antibodies  >40 publications with SFRP2 and Carcinoma
 Colorectal Neoplasms Antibodies  >26 publications with SFRP2 and Colorectal Neoplasms
 Adenocarcinoma Antibodies  >18 publications with SFRP2 and Adenocarcinoma
 Leukemia Antibodies  >15 publications with SFRP2 and Leukemia
 Cardiovascular Diseases Antibodies  >12 publications with SFRP2 and Cardiovascular Diseases
 Colonic Neoplasms Antibodies  >11 publications with SFRP2 and Colonic Neoplasms
 Carcinoma, Squamous Cell Antibodies  >9 publications with SFRP2 and Carcinoma, Squamous Cell
 Skin Diseases Antibodies  >8 publications with SFRP2 and Skin Diseases
 Fibrosis Antibodies  >8 publications with SFRP2 and Fibrosis

Organs/Tissues associated with anti-SFRP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >41 publications with SFRP2 and Eye
 Bone Antibodies  >28 publications with SFRP2 and Bone
 Muscle Antibodies  >26 publications with SFRP2 and Muscle
 Embryonic Tissue Antibodies  >26 publications with SFRP2 and Embryonic Tissue
 Kidney Antibodies  >12 publications with SFRP2 and Kidney
 Brain Antibodies  >12 publications with SFRP2 and Brain
 Heart Antibodies  >11 publications with SFRP2 and Heart
 Intestine Antibodies  >10 publications with SFRP2 and Intestine
 Nerve Antibodies  >8 publications with SFRP2 and Nerve
 Connective Tissue Antibodies  >8 publications with SFRP2 and Connective Tissue
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