CREM Antibody – Mouse Monoclonal

This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]

CREM: a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. An important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative splice isoforms allow this protein to exert spatial and temporal specificity to cAMP responsiveness. Twentyeight alternatively spliced isoforms of the human protein have been described, with some of them functioning as activators and some as repressors of transcription.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 10p11.21

Cellular Component: transcription factor complex; cytoplasm; nucleus

Molecular Function: protein binding; DNA binding; cAMP response element binding protein binding; transcription factor activity

Biological Process: response to cAMP; regulation of transcription, DNA-dependent; transcription, DNA-dependent; multicellular organismal development; positive regulation of transcription from RNA polymerase II promoter; glycosphingolipid metabolic process; spermatogenesis; circadian regulation of gene expression; signal transduction; negative regulation of transcription, DNA-dependent; cell differentiation