Dexras1 (RASD1) Antibody – Rabbit Polyclonal

This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65 which interacts with the Alzheimer's disease amyloid precursor protein (APP). This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have beeen found for this gene.

RASD1: Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65. Forms a ternary complex with CAPON and NOS1. Component of a complex, at least composed of APBB1, RASD1/DEXRAS1 and APP. Interacts with APBB1/FE65. By dexamethasone. Expressed in a variety of tissues including heart, cardiovascular tissues, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, gastrointestinal and reproductive tissues. Belongs to the small GTPase superfamily. RasD family.

Protein type: G protein; G protein, monomeric; G protein, monomeric, RasD

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: perinuclear region of cytoplasm; plasma membrane; nucleus

Molecular Function: GTPase activity; GTP binding

Biological Process: G-protein coupled receptor protein signaling pathway; metabolic process; small GTPase mediated signal transduction; negative regulation of transcription, DNA-dependent; signal transduction; nitric oxide mediated signal transduction