Rabbit Anti-ARHGEF10 Polyclonal Antibody – Cat# MBS620209

ARHGEF10 (20ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human brain, cerebellum, followed by biotinylated goat rabbit IgG secondary, alkaline phosphatase-streptavidin and chromogen.

Rho Guanine Nucleotide Exchange Factor 10 (ARHGEF10) Antibody – Rabbit Polyclonal

Name: ARHGEF10 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS620209
Price: 785 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS620209

MBS620209 is an antibody targeting ARHGEF10. Also known as Rho Guanine Nucleotide Exchange Factor 10 (ARHGEF10, DKFZP686H0726, GEF10, KIAA0294, MGC131664). Reactive in Human. Host: Rabbit. More details

$785 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Rho Guanine Nucleotide Exchange Factor 10 (ARHGEF10), Polyclonal Antibody

Full Product Name

Rho Guanine Nucleotide Exchange Factor 10 (ARHGEF10, DKFZP686H0726, GEF10, KIAA0294, MGC131664)

Product Gene Name

anti-ARHGEF10 antibody

Product Synonym Names

Anti -Rho Guanine Nucleotide Exchange Factor 10 (ARHGEF10, DKFZP686H0726, GEF10, KIAA0294, MGC131664)

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, 0.1% sodium azide.

Specificity

Recognizes Human Rho Guanine Nucleotide Exchange Factor (GEF) 10 (ARHGEF10). Species Crossreactivity: Human.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

151,612 Da

Chromosome Location

Chromosome: 8; NC_000008.10 (1772149..1906807). Location: 8p23

OMIM

608136

3D Structure

ModBase 3D Structure for O15013

Immunogen

Synthetic peptide - KLH conjugated

Product Categories/Family for anti-ARHGEF10 antibody

Antibodies; Abs to GTPase; Rab; Ras; Rho Proteins

Applications Tested/Suitable for anti-ARHGEF10 antibody

ELISA (EL/EIA), Immunohistochemistry (IHC)

Application Notes for anti-ARHGEF10 antibody

Suitable for use in ELISA and Immunohistochemistry.
Dilution: ELISA: 1:10-1:1000
Immunohistochemistry: 20ug/ml

Other Notes

Small volumes of anti-ARHGEF10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ARHGEF10. It may not necessarily be applicable to this product.

NCBI GI #

62548864

NCBI GeneID

9639

NCBI Accession #

NP_055444.2

UniProt Primary Accession #

O15013

UniProt Secondary Accession #

O14665; Q2KHR8; Q68D55; Q8IWD9; Q8IY77

UniProt Related Accession #

O15013; Q69YW1

GenBank Nucleotide #

NM_014629.2

NCBI Official Full Name

rho guanine nucleotide exchange factor 10

NCBI Official Synonym Full Names

Rho guanine nucleotide exchange factor (GEF) 10

NCBI Official Symbol

ARHGEF10

NCBI Official Synonym Symbols

GEF10; MGC131664; DKFZp686H0726

UniProt Protein Name

Rho guanine nucleotide exchange factor 10

Protein Family

Rho guanine nucleotide exchange factor

UniProt Gene Name

ARHGEF10

UniProt Synonym Gene Names

KIAA0294

UniProt Entry Name

ARHGA_HUMAN

NCBI Protein Information

rho guanine nucleotide exchange factor 10; OTTHUMP00000224478; OTTHUMP00000224479; OTTHUMP00000224480; OTTHUMP00000224481

NCBI Summary for ARHGEF10

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. [provided by RefSeq]

UniProt Comments for ARHGEF10

ARHGEF10: May play a role in developmental myelination of peripheral nerves. Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV). Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho

Chromosomal Location of Human Ortholog: 8p23

Cellular Component: centrosome; cytosol

Molecular Function: protein binding; Rho guanyl-nucleotide exchange factor activity; kinesin binding

Biological Process: positive regulation of stress fiber formation; centrosome duplication; myelination in the peripheral nervous system

Disease: Slowed Nerve Conduction Velocity, Autosomal Dominant

Research Articles on ARHGEF10

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ARHGEF10 antibody

Products by Pathway	Pathway Diagram
Regulation Of RhoA Activity Pathway antibodies	Regulation Of RhoA Activity Pathway Diagram

Diseases associated with anti-ARHGEF10 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>4 publications with ARHGEF10 and Neoplasms
Pancreatic Neoplasms Antibodies	>2 publications with ARHGEF10 and Pancreatic Neoplasms
Liver Neoplasms Antibodies	>1 publications with ARHGEF10 and Liver Neoplasms
Breast Neoplasms Antibodies	>1 publications with ARHGEF10 and Breast Neoplasms
Urologic Neoplasms Antibodies	>1 publications with ARHGEF10 and Urologic Neoplasms
Urinary Bladder Neoplasms Antibodies	>1 publications with ARHGEF10 and Urinary Bladder Neoplasms
Endocrine Gland Neoplasms Antibodies	>1 publications with ARHGEF10 and Endocrine Gland Neoplasms

Organs/Tissues associated with anti-ARHGEF10 antibody

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>4 publications with ARHGEF10 and Nerve
Brain Antibodies	>2 publications with ARHGEF10 and Brain
Pancreas Antibodies	>1 publications with ARHGEF10 and Pancreas
Liver Antibodies	>1 publications with ARHGEF10 and Liver
Muscle Antibodies	>1 publications with ARHGEF10 and Muscle