• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

GRIK4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS620371

Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons (1,2). Five subunits can… More details

$850 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Grik4, Polyclonal Antibody
Full Product Name
Grik4, CT (Glutamate receptor ionotropic kainate 4 precursor, EAA1, Excitatory amino acid receptor 1, Glutamate receptor KA-1, GRIK, KA1)
Product Gene Name
anti-GRIK4 antibody
Product Synonym Names
Anti -Grik4, CT (Glutamate receptor ionotropic kainate 4 precursor, EAA1, Excitatory amino acid receptor 1, Glutamate receptor KA-1, GRIK, KA1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human Grik4. Species crossreactivity: Mouse and rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
107,246 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (120531028..120856969). Location: 11q22.3
OMIM
600282
3D Structure
ModBase 3D Structure for Q16099
Immunogen
Synthetic peptide corresponding to 19aa from near the carboxy terminus of the human Grik4 (GenBank accession no. Q16099).

Product Categories/Family for anti-GRIK4 antibody

Antibodies; Abs to Receptors
Applications Tested/Suitable for anti-GRIK4 antibody
Western Blot (WB)
Application Notes for anti-GRIK4 antibody
Dilution: Western Blot: 0.5-1ug/ml

Western Blot (WB) of anti-GRIK4 antibody

Western blot analysis of Grik4 in rat brain lysate with Grik4 antibody at (A) 0.5 (B) 1 and (C) 2 ug/ml.
Rabbit Anti-GRIK4 Polyclonal Antibody – Cat# MBS620371

Other Notes

Small volumes of anti-GRIK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRIK4 purchase

MBS620371 is an antibody targeting GRIK4. Also known as Grik4, CT (Glutamate receptor ionotropic kainate 4 precursor, EAA1, Excitatory amino acid receptor 1, Glutamate receptor KA-1, GRIK, KA1). Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GRIK4. It may not necessarily be applicable to this product.

NCBI GI #
29029595
NCBI GeneID
2900
NCBI Accession #
NP_055434.2
UniProt Primary Accession #
Q16099
UniProt Secondary Accession #
A8K9L1
UniProt Related Accession #
Q16099; Q3C1X2
GenBank Nucleotide #
NM_014619.2
NCBI Official Full Name
glutamate receptor, ionotropic kainate 4
NCBI Official Synonym Full Names
glutamate receptor, ionotropic, kainate 4
NCBI Official Symbol
GRIK4
NCBI Official Synonym Symbols
KA1; EAA1; GRIK
UniProt Protein Name
Glutamate receptor, ionotropic kainate 4
UniProt Synonym Protein Names
Excitatory amino acid receptor 1; EAA1; Glutamate receptor KA-1
Protein Family
Glutamate receptor ionotropic
UniProt Gene Name
GRIK4
UniProt Synonym Gene Names
GRIK
UniProt Entry Name
GRIK4_HUMAN
NCBI Protein Information
glutamate receptor, ionotropic kainate 4; OTTHUMP00000045951; OTTHUMP00000231881; glutamate receptor KA1; glutamate receptor KA-1; excitatory amino acid receptor 1

NCBI Summary for GRIK4

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. [provided by RefSeq]
Show more

UniProt Comments for GRIK4

GluR KA1: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily.

Protein type: Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: presynaptic membrane; postsynaptic membrane; kainate selective glutamate receptor complex; integral to plasma membrane; dendrite; plasma membrane; terminal button; perikaryon; cell junction; nucleus

Molecular Function: kainate selective glutamate receptor activity; extracellular-glutamate-gated ion channel activity

Biological Process: synaptic transmission; synaptic transmission, glutamatergic; transport; ionotropic glutamate receptor signaling pathway; glutamate signaling pathway; response to corticosteroid stimulus
Show more

Research Articles on GRIK4

1. Activation of kainate receptors could serve as a novel mechanism for enhancing B cell activation and immunoglobulin production.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GRIK4 antibody

 Reference Product  PubMed Publications
 GRIK2 antibody  >3 publications with GRIK4 and GRIK2

Pathways associated with anti-GRIK4 antibody

 Products by Pathway  Pathway Diagram
 Activation Of Ca-permeable Kainate Receptor Pathway antibodies  Activation Of Ca-permeable Kainate Receptor Pathway Diagram
 Activation Of Kainate Receptors Upon Glutamate Binding Pathway antibodies  Activation Of Kainate Receptors Upon Glutamate Binding Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Ionotropic Activity Of Kainate Receptors Pathway antibodies  Ionotropic Activity Of Kainate Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies  Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram
 Synaptic Transmission Pathway antibodies  Synaptic Transmission Pathway Diagram
 Transmission Across Chemical Synapses Pathway antibodies  Transmission Across Chemical Synapses Pathway Diagram

Diseases associated with anti-GRIK4 antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >20 publications with GRIK4 and Mental Disorders
 Schizophrenia Antibodies  >9 publications with GRIK4 and Schizophrenia
 Nervous System Diseases Antibodies  >5 publications with GRIK4 and Nervous System Diseases
 Psychotic Disorders Antibodies  >2 publications with GRIK4 and Psychotic Disorders
 Dementia Antibodies  >1 publications with GRIK4 and Dementia

Organs/Tissues associated with anti-GRIK4 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with GRIK4 and Brain
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000