Rabbit Anti-CDCA8 Polyclonal Antibody – Cat# MBS620401

Western blot analysis of CDCA8 in Rat kidney lysate with CDCA8 antibody at (A) 1 and (B) 2 ug/ml.

Cell Division Cycle Associated 8 (CDCA8) Antibody – Rabbit Polyclonal

Name: CDCA8 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS620401
Price: 850 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS620401

CDCA8 is a component of a chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle. The chromosomal passenger complex, which includes Survivin, CDCA8, INCENP and Aurora-B, is known to play crucial roles during mitosis and cell… More details

$850 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cell division cycle associated 8 (CDCA8), Polyclonal Antibody

Full Product Name

Cell division cycle associated 8 (BOR, Borealin, BOREALIN, Cell division cycle-associated protein 8, Dasra-B, FLJ10468, FLJ12042, hDasra-B, PESCRG3, Pluripotent embryonic stem cell-related gene 3 protein)

Product Gene Name

anti-CDCA8 antibody

Product Synonym Names

Anti -Cell division cycle associated 8 (BOR, Borealin, BOREALIN, Cell division cycle-associated protein 8, Dasra-B, FLJ10468, FLJ12042, hDasra-B, PESCRG3, Pluripotent embryonic stem cell-related gene 3 protein)

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Supplied as a liquid in PBS containing 0.02% sodium azide.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes human CDCA8. Species Crossreactivity: Mouse and rat.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

31,323 Da

Chromosome Location

Chromosome: 1; NC_000001.10 (38158159..38175391). Location: 1p34.3

OMIM

609977

3D Structure

ModBase 3D Structure for Q53HL2

Immunogen

Synthetic peptide corresponding to 19aa near the amino terminus of the human CDCA8.

Positive Control

Rat Kidney Tissue Lysate

Product Categories/Family for anti-CDCA8 antibody

Antibodies; Abs to Cell Division Cycle (CDC)

Applications Tested/Suitable for anti-CDCA8 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-CDCA8 antibody

Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1ug/ml

Other Notes

Small volumes of anti-CDCA8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDCA8 purchase

MBS620401 is an antibody targeting CDCA8. Also known as Cell division cycle associated 8 (BOR, Borealin, BOREALIN, Cell division cycle-associated protein 8, Dasra-B, FLJ10468, FLJ12042, hDasra-B, PESCRG3, Pluripotent embryonic stem cell-related gene 3 protein). Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CDCA8. It may not necessarily be applicable to this product.

NCBI GI #

16877392

NCBI GeneID

55143

UniProt Primary Accession #

Q53HL2

UniProt Secondary Accession #

Q53HN1; Q96AM3; Q9NVW5; D3DPT4

UniProt Related Accession #

Q53HL2

NCBI Official Full Name

Cell division cycle associated 8

NCBI Official Synonym Full Names

cell division cycle associated 8

NCBI Official Symbol

CDCA8

NCBI Official Synonym Symbols

BOR; DasraB; MESRGP; BOREALIN; FLJ10468; FLJ12042

UniProt Protein Name

Borealin

UniProt Synonym Protein Names

Cell division cycle-associated protein 8; Dasra-B; hDasra-B; Pluripotent embryonic stem cell-related gene 3 protein

UniProt Gene Name

CDCA8

UniProt Synonym Gene Names

PESCRG3

UniProt Entry Name

BOREA_HUMAN

NCBI Protein Information

borealin; Dasra B; dasra-B; hDasra-B; OTTHUMP00000004514; OTTHUMP00000004515; cell division cycle-associated protein 8; pluripotent embryonic stem cell-related gene 3 protein

NCBI Summary for CDCA8

CDCA8 is a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle (Gassmann et al., 2004 [PubMed 15249581]).[supplied by OMIM]

UniProt Comments for CDCA8

Borealin: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. Belongs to the borealin family.

Protein type: Nucleolus; Cell cycle regulation

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: intercellular bridge; protein complex; nucleolus; spindle; midbody; cytosol; nucleus; chromosome, pericentric region; chromocenter

Molecular Function: protein binding

Biological Process: cell division; mitotic cell cycle; mitotic metaphase plate congression; chromosome organization and biogenesis

Research Articles on CDCA8

1. important role for phosphorylation of Borealin at S219 in the proper progression through mitosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CDCA8 antibody

Reference Product	PubMed Publications
BIRC5 antibody	>19 publications with CDCA8 and BIRC5
INCENP antibody	>18 publications with CDCA8 and INCENP
AURKB antibody	>1 publications with CDCA8 and AURKB

Pathways associated with anti-CDCA8 antibody

Products by Pathway	Pathway Diagram
Aurora B Signaling Pathway antibodies	Aurora B Signaling Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram
DNA Replication Pathway antibodies	DNA Replication Pathway Diagram
M Phase Pathway antibodies	M Phase Pathway Diagram
Mitotic M-M/G1 Phases Pathway antibodies	Mitotic M-M/G1 Phases Pathway Diagram
Mitotic Prometaphase Pathway antibodies	Mitotic Prometaphase Pathway Diagram

Diseases associated with anti-CDCA8 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>7 publications with CDCA8 and Neoplasms
Genital Neoplasms, Female Antibodies	>2 publications with CDCA8 and Genital Neoplasms, Female
Stomach Neoplasms Antibodies	>1 publications with CDCA8 and Stomach Neoplasms
Ovarian Diseases Antibodies	>1 publications with CDCA8 and Ovarian Diseases
Uterine Diseases Antibodies	>1 publications with CDCA8 and Uterine Diseases
Drug Toxicity Antibodies	>1 publications with CDCA8 and Drug Toxicity
Anemia Antibodies	>1 publications with CDCA8 and Anemia
Uterine Cervical Neoplasms Antibodies	>1 publications with CDCA8 and Uterine Cervical Neoplasms
Lung Neoplasms Antibodies	>1 publications with CDCA8 and Lung Neoplasms
Ovarian Neoplasms Antibodies	>1 publications with CDCA8 and Ovarian Neoplasms

Organs/Tissues associated with anti-CDCA8 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>2 publications with CDCA8 and Blood
Uterus Antibodies	>2 publications with CDCA8 and Uterus
Spleen Antibodies	>1 publications with CDCA8 and Spleen
Bone Marrow Antibodies	>1 publications with CDCA8 and Bone Marrow
Bone Antibodies	>1 publications with CDCA8 and Bone
Stomach Antibodies	>1 publications with CDCA8 and Stomach
Lung Antibodies	>1 publications with CDCA8 and Lung
Cervix Antibodies	>1 publications with CDCA8 and Cervix
Embryonic Tissue Antibodies	>1 publications with CDCA8 and Embryonic Tissue
Brain Antibodies	>1 publications with CDCA8 and Brain