Goat Anti-STXBP1 Polyclonal Antibody – Cat# MBS620460

Detection of Syntaxin-BP1. Tissue lysates were resolved by SDS-PAGE, transferred to an Immobilon-P membrane and immunoblotted with 1.0ug/ml goat anti-h/m/r Syntaxin-BP1.

Syntaxin-Binding Protein 1 (STXBP1) Antibody – Goat Polyclonal

Name: STXBP1 Antibody; Polyclonal; Goat; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS620460
Price: 1090 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS620460

STXBP1 (Syntaxin-binding protein 1; also p67, Munc18-1, N-Sec1 and Unc18A) is a 67kD member of the SNARE-interacting Sec1/Unc18/STXBP family of proteins. It is expressed in a variety of cells, presumably in those that exhibit granule exocytosis, and likely… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Syntaxin-binding protein 1 (Stxbp1), Polyclonal Antibody

Full Product Name

Syntaxin-binding protein 1 (Syntaxin-BP1, p67, Munc18-1, N-Sec1, Unc18A)

Product Gene Name

anti-Stxbp1 antibody

Product Synonym Names

Anti -Syntaxin-binding protein 1 (Syntaxin-BP1, p67, Munc18-1, N-Sec1, Unc18A)

Clonality

Polyclonal

Isotype

IgG

Host

Goat

Species Reactivity

Human, Mouse, Rat

Form/Format

Supplied as a lyophilized powder in 0.2um sterile-filtered solution, PBS, 5% trehalose. Reconstitute with 40-50% glycerol, PBS.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes human, mouse, rat Syntaxin-BP1.

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile 40-50% glycerol, PBS.. Aliquot and store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

67,569 Da

Chromosome Location

Chromosome: 3; NC_005102.2 (11762105..11825531, complement). Location: 3p11

3D Structure

ModBase 3D Structure for P61765

Immunogen

Recombinant human Syntaxin-BP1 aa80-226; P61764 (E. coli).

Product Categories/Family for anti-Stxbp1 antibody

Antibodies; Abs to Binding Proteins

Applications Tested/Suitable for anti-Stxbp1 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-Stxbp1 antibody

Dilution: ELISA: 0.5-1.0ug/ml
Western Blot: 1.0ug/ml

Other Notes

Small volumes of anti-Stxbp1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Stxbp1 purchase

MBS620460 is an antibody targeting Stxbp1. Also known as Syntaxin-binding protein 1 (Syntaxin-BP1, p67, Munc18-1, N-Sec1, Unc18A). Reactive in Human, Mouse, Rat. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for Stxbp1. It may not necessarily be applicable to this product.

NCBI GI #

6981602

NCBI GeneID

25558

NCBI Accession #

NP_037170.1

UniProt Primary Accession #

P61765

UniProt Secondary Accession #

Q28208; Q62759; Q64320; Q96TG8

UniProt Related Accession #

P61765

GenBank Nucleotide #

NM_013038.3

NCBI Official Full Name

syntaxin-binding protein 1

NCBI Official Synonym Full Names

syntaxin binding protein 1

NCBI Official Symbol

Stxbp1

NCBI Official Synonym Symbols

Sec1; nSec1; NSEC1A; n-sec1; rbSec1; ANC18HA; Unc18-1; rbSec1A; rbSec1B; Munc18-1

UniProt Protein Name

Syntaxin-binding protein 1

UniProt Synonym Protein Names

N-Sec1; Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A; p67; rbSec1

Protein Family

Syntaxin-binding protein

UniProt Gene Name

Stxbp1

UniProt Synonym Gene Names

Unc18a

UniProt Entry Name

STXB1_RAT

NCBI Protein Information

syntaxin-binding protein 1; p67; unc-18A; unc-18-1; unc-18 homolog; protein unc-18 homolog 1; protein unc-18 homolog A

NCBI Summary for Stxbp1

inhibits binding of synaptobrevin and SNAP-25 to syntaxin 1A to modulate SNARE complex formation; acts to regulate neurotransmission [RGD]

UniProt Comments for Stxbp1

STXBP1: may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. Two splice-variant isoforms have been described.

Protein type: Vesicle

Cellular Component: nucleoplasm; protein complex; mitochondrion; cell; cytoplasm; plasma membrane; terminal button; cytosol; myelin sheath

Molecular Function: protein domain specific binding; identical protein binding; SNARE binding; protein binding; syntaxin binding; syntaxin-1 binding; protein N-terminus binding; protein kinase binding

Biological Process: positive regulation of calcium ion-dependent exocytosis; protein transport; exocytosis; axon target recognition; platelet degranulation; protein stabilization; synaptic vesicle maturation; neurotransmitter secretion; neuromuscular synaptic transmission; negative regulation of neuron apoptosis; negative regulation of synaptic transmission, GABAergic; vesicle docking during exocytosis; positive regulation of exocytosis

Research Articles on Stxbp1

1. The results of molecular dynamics simulations suggest that the free wild-type munc18a exhibits a dynamic equilibrium between several conformations differing in the size of its cavity (the main syntaxin-binding site).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Stxbp1 antibody

Reference Product	PubMed Publications
Stx1a antibody	>17 publications with Stxbp1 and Stx1a
Apba1 antibody	>3 publications with Stxbp1 and Apba1
Sytl4 antibody	>1 publications with Stxbp1 and Sytl4
Pld2 antibody	>1 publications with Stxbp1 and Pld2

Pathways associated with anti-Stxbp1 antibody

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Glutamate Neurotransmitter Release Cycle Pathway antibodies	Glutamate Neurotransmitter Release Cycle Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram
Integration Of Energy Metabolism Pathway antibodies	Integration Of Energy Metabolism Pathway Diagram
Neurotransmitter Release Cycle Pathway antibodies	Neurotransmitter Release Cycle Pathway Diagram
Norepinephrine Neurotransmitter Release Cycle Pathway antibodies	Norepinephrine Neurotransmitter Release Cycle Pathway Diagram
Regulation Of Insulin Secretion Pathway antibodies	Regulation Of Insulin Secretion Pathway Diagram
Synaptic Transmission Pathway antibodies	Synaptic Transmission Pathway Diagram

Diseases associated with anti-Stxbp1 antibody

Disease Name	Pubmed Publications
Mental Disorders Antibodies	>8 publications with Stxbp1 and Mental Disorders
Neoplasms Antibodies	>3 publications with Stxbp1 and Neoplasms
Epilepsies, Myoclonic Antibodies	>3 publications with Stxbp1 and Epilepsies, Myoclonic
Schizophrenia Antibodies	>2 publications with Stxbp1 and Schizophrenia
Death Antibodies	>2 publications with Stxbp1 and Death
Carcinoma Antibodies	>1 publications with Stxbp1 and Carcinoma
Hyperglycemia Antibodies	>1 publications with Stxbp1 and Hyperglycemia
Ataxia Antibodies	>1 publications with Stxbp1 and Ataxia
Necrosis Antibodies	>1 publications with Stxbp1 and Necrosis
Embryo Loss Antibodies	>1 publications with Stxbp1 and Embryo Loss

Organs/Tissues associated with anti-Stxbp1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>50 publications with Stxbp1 and Brain
Embryonic Tissue Antibodies	>10 publications with Stxbp1 and Embryonic Tissue
Pancreas Antibodies	>3 publications with Stxbp1 and Pancreas
Testis Antibodies	>3 publications with Stxbp1 and Testis
Adrenal Gland Antibodies	>2 publications with Stxbp1 and Adrenal Gland
Ovary Antibodies	>2 publications with Stxbp1 and Ovary
Eye Antibodies	>2 publications with Stxbp1 and Eye
Pineal Gland Antibodies	>2 publications with Stxbp1 and Pineal Gland
Dorsal Root Ganglion Antibodies	>2 publications with Stxbp1 and Dorsal Root Ganglion
Pituitary Gland Antibodies	>1 publications with Stxbp1 and Pituitary Gland