MARK1 Antibody – Goat Polyclonal

Microtubule associated proteins regulate the stability of microtubules, controlling processes such as cell polarity/differentiation, neurite outgrowth, cell division and organelle trafficking. The MARK (MAP/microtubule affinity-regulating kinases) family (MARK1-4) of serine/threonine kinases were identified based on their ability to phosphorylate microtubule associated proteins (MAPs) including tau, MAP2 and MAP4. MARKs phosphorylate MAPs within their microtubule binding domains, causing dissociation of MAPs from microtubules and increased microtubule dynamics. In the case of tau, phosphorylation has been hypothesized to contribute to the formation of neurofibrillary tangles observed in Alzheimer's disease. Overexpression of MARK leads to hyperphosphorylation of MAPs, morphological changes and cell death. The tumor suppressor kinase LKB1 phosphorylates MARK and the closely related AMP-kinases within their T-loops, leading to increased activity.

Small volumes of anti-MARK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS620659 is an antibody targeting MARK1. Also known as Mark1 (MAP/microtubule Affinity-regulating Kinase 1, ELKL Motif Serine/threonine-protein Kinase 3, Emk3, Kiaa1477, PAR1 Homolog c, Par-1c, mPar-1c, Serine/threonine-protein Kinase MARK1). Reactive in Mouse. Host: Goat.