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Dcr3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS620825

Decoy Receptor 3 is a 33kD member of the tumor necrosis factor receptor superfamily. DcR3 acts as a receptor for FasL and LIGHT, preventing them from binding to their cell death receptors and thereby inhibiting apoptosis. DcR3 is a soluble decoy receptor… More details

$830 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DcR3, Polyclonal Antibody
Full Product Name
DcR3, NT (TR6, Decoy Receptor 3, TNFRSF6B, TR6, M68)
Product Synonym Names
Anti -DcR3, NT (TR6, Decoy Receptor 3, TNFRSF6B, TR6, M68)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Purity/Purification
Highly Purified
Purified by ion exchange chromatography.
Specificity
Recognizes the N-terminus of human DcR3, otherwise known as Decoy Receptor 3, at ~33kD. Species crossreactivity: mouse and rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Synthetic peptide corresponding to amino acids near the N-terminus of human DcR3 precursor.
Positive Control
WB: Human heart lysate

Product Categories/Family for anti-DcR3 antibody

Applications Tested/Suitable for anti-DcR3 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-DcR3 antibody
Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot: 0.5-1ug/ml
Immunohistochemistry (Paraffin): 1ug/ml. Requires heat induced epitope retrieval. Sodium citrate buffer pH 6.0 is recommended for this purpose.

Immunohistochemistry (IHC) of anti-DcR3 antibody

Immunohistochemistry staining of human heart with MBS620825.
Rabbit Anti-Dcr3 Polyclonal Antibody – Cat# MBS620825

Other Notes

Small volumes of anti-DcR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DcR3 purchase

MBS620825 is an antibody targeting DcR3. Also known as DcR3, NT (TR6, Decoy Receptor 3, TNFRSF6B, TR6, M68). Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DcR3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI Official Full Name
decoy receptor 3 variant 2

NCBI Summary for DcR3

This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]
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UniProt Comments for DcR3

TNFRSF6B: Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: extracellular space

Molecular Function: protein binding; receptor activity

Biological Process: apoptosis; negative regulation of apoptosis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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