Glutamic Acid Decarboxylase Antibody – Rabbit Polyclonal

g-Aminobutyric acid (GABA) is the major known inhibitory neurotransmitter. The rate-limiting step in the synthesis of GABA is the decarboxylation of glutamate by glutamate decarboxylase (GAD; L-glutamate 1-carboxy-lyase, EC 4.1.115). In the CNS GAB is entirely restricted to GABAergic neurons. GAD is also present in the b-cells of the pancreas and autoantibodies to various GAD polypeptides are detected in insulin-dependent diabetes mellitus. Cloning of GAD genes have identified two subtypes: GAD65 (65kD; human 585 AA chromosome 10) and GAD67 (67kD; human 594 AA, chromosome 2) share approx. 65% amino acid homology. The N-terminus is the most divergent while the C-terminus is highly conserved. Although both GAD isoforms catalyzes the conversion of GABA but interact differently with the co-factor pyridoxal 5\'-phosphate suggesting their activities are differentially regulated. GAD67 is cytosolic, while GAD65 is membrane associated. GAD65 is a major autoantigen in diabetes mellitus and stiff-man syndrome, a rare disease of the brain.

• 1. Wyborksi RJ et al (1990) Mol. Brain,. Res. 8, 193-198;  Julien JF et al (1990) J Neurochem.  54, 703;  Katarove Z et al (1990) Ewur. J. Neurosci.  2, 190;  Michelson BK et al (1992) Diabetes 41, 1182;  Faulkner-Jones BE (1993) Endocrinol.  133, 2962; 
• 2. Dirkxx R et al (1995) JBC 270, 2241;  Solimena M (unpublihsed results on file).

Small volumes of anti-Glutamic Acid Decarboxylase antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS620847 is an antibody targeting Glutamic Acid Decarboxylase. Also known as Anti - Glutamic Acid Decarboxylase (GAD). Reactive in Human. Host: Rabbit.