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FOXH1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS620886

Forkhead box H1 (FOXH1) is a member of the HNF-3FKH family of transcriptional activators. FOXH1 is a winged helix with two loops on the C-terminal side expressed in all human tissue. FOXH1 is an embryonic transcription regulator and is an essential… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
FOXH1, Polyclonal Antibody
Full Product Name
FOXH1 (Forkhead Box H1, Human Homolog of Xenopus Forkhead Activin Signal Transducer 1)
Product Gene Name
anti-FOXH1 antibody
Product Synonym Names
Anti -FOXH1 (Forkhead Box H1, Human Homolog of Xenopus Forkhead Activin Signal Transducer 1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied in liquid in 50% saturated ammonium sulfate and PBS. No preservative added.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human FOXH1. Species sequence homology: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
39,257 Da
Chromosome Location
Chromosome: 8; NC_000008.10 (145699115..145701718, complement). Location: 8q24.3
OMIM
603621
3D Structure
ModBase 3D Structure for O75593
Immunogen
Synthetic to peptide corresponding to FOXH1. Cellular Localization: Nucleus.

Product Categories/Family for anti-FOXH1 antibody

Antibodies; Abs to Transcription Factors
Applications Tested/Suitable for anti-FOXH1 antibody
Immunocytochemistry (ICC)
Application Notes for anti-FOXH1 antibody
Suitable for use in Immunocytochemistry.
Dilution: Immunocytochemistry: 1:500

Immunocytochemistry (ICC) of anti-FOXH1 antibody

Immunocytochemistry: Representative lot data. Confocal fluorescent analysis of HeLa, A431, and NIH/3T3 using anti-FOXH1 antibody (Red). Actin filaments have been labeled with Alexa Fluor 488 -Phalloidin (Green). Nuclei are stained with DAPI (Blue). Antibody shows positive nuclear staining.
Rabbit Anti-FOXH1 Polyclonal Antibody – Cat# MBS620886

Other Notes

Small volumes of anti-FOXH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FOXH1 purchase

MBS620886 is an antibody targeting FOXH1. Also known as FOXH1 (Forkhead Box H1, Human Homolog of Xenopus Forkhead Activin Signal Transducer 1). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FOXH1. It may not necessarily be applicable to this product.

NCBI GI #
4503657
NCBI GeneID
8928
NCBI Accession #
NP_003914.1
UniProt Primary Accession #
O75593
UniProt Secondary Accession #
D3DWM4
UniProt Related Accession #
O75593; Q6P0Y2
GenBank Nucleotide #
NM_003923.2
NCBI Official Full Name
forkhead box protein H1
NCBI Official Synonym Full Names
forkhead box H1
NCBI Official Symbol
FOXH1
NCBI Official Synonym Symbols
FAST1; FAST-1
UniProt Protein Name
Forkhead box protein H1
UniProt Synonym Protein Names
Forkhead activin signal transducer 1; Fast-1; hFAST-1; Forkhead activin signal transducer 2
Protein Family
Forkhead box protein
UniProt Gene Name
FOXH1
UniProt Synonym Gene Names
FAST1; FAST2
UniProt Entry Name
FOXH1_HUMAN
NCBI Protein Information
forkhead box protein H1; fast-2; hFAST-1; OTTHUMP00000228774; TGF-beta/activin signal transducer; forkhead activin signal transducer 1; forkhead activin signal transducer 2; forkhead activin signal transducer-1

NCBI Summary for FOXH1

FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT. [provided by RefSeq]

UniProt Comments for FOXH1

FOXH1: Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).

Protein type: DNA-binding; Nuclear receptor co-regulator; Transcription factor

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: nucleoplasm; transcription factor complex; nuclear chromatin; nucleus

Molecular Function: protein domain specific binding; protein binding; DNA binding; androgen receptor binding; sequence-specific DNA binding; bHLH transcription factor binding; SMAD binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; embryonic heart tube anterior/posterior pattern formation; positive regulation of transcription, DNA-dependent; axial mesoderm development; transforming growth factor beta receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; heart looping; negative regulation of estrogen receptor signaling pathway

Disease: Holoprosencephaly 1
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Research Articles on FOXH1

1. Results suggest that PKA can negatively regulate ERalpha, at least in part, through FoxH1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FOXH1 antibody

 Reference Product  PubMed Publications
 SMAD2 antibody  >48 publications with FOXH1 and SMAD2
 SMAD4 antibody  >28 publications with FOXH1 and SMAD4
 SMAD3 antibody  >21 publications with FOXH1 and SMAD3
 NKX2-5 antibody  >4 publications with FOXH1 and NKX2-5
 FOXG1 antibody  >2 publications with FOXH1 and FOXG1
 DRAP1 antibody  >2 publications with FOXH1 and DRAP1

Pathways associated with anti-FOXH1 antibody

 Products by Pathway  Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 Regulation Of Nuclear SMAD2/3 Signaling Pathway antibodies  Regulation Of Nuclear SMAD2/3 Signaling Pathway Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram

Diseases associated with anti-FOXH1 antibody

 Disease Name  Pubmed Publications
 Heart Defects, Congenital Antibodies  >4 publications with FOXH1 and Heart Defects, Congenital
 Craniofacial Abnormalities Antibodies  >3 publications with FOXH1 and Craniofacial Abnormalities
 Nervous System Malformations Antibodies  >3 publications with FOXH1 and Nervous System Malformations
 Breast Neoplasms Antibodies  >2 publications with FOXH1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >2 publications with FOXH1 and Adenocarcinoma
 Prostatic Neoplasms Antibodies  >1 publications with FOXH1 and Prostatic Neoplasms
 Eye Abnormalities Antibodies  >1 publications with FOXH1 and Eye Abnormalities
 Prostatic Diseases Antibodies  >1 publications with FOXH1 and Prostatic Diseases
 Gonadal Disorders Antibodies  >1 publications with FOXH1 and Gonadal Disorders

Organs/Tissues associated with anti-FOXH1 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >8 publications with FOXH1 and Embryonic Tissue
 Ovary Antibodies  >1 publications with FOXH1 and Ovary
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