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LGALS3 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6209949

This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
LGALS3, Monoclonal Antibody
Full Product Name
LGALS3, CT (LGALS3, MAC2, Galectin-3, 35kD lectin, Carbohydrate-binding protein 35, Galactose-specific lectin 3, Galactoside-binding protein, IgE-binding protein, L-31, Laminin-binding protein, Lectin L-29, Mac-2 antigen) (MaxLight 550)
Product Gene Name
anti-LGALS3 antibody
Product Synonym Names
LGALS3; MAC2; Galectin-3; 35kD lectin; Carbohydrate-binding protein 35; Galactose-specific lectin 3; Galactoside-binding protein; IgE-binding protein; L-31; Laminin-binding protein; Lectin L-29; Mac-2 antigen
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
320CT4.5.2
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Protein G Affinity Chromatography
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
26,152 Da
Chromosome Location
Chromosome: 14; NC_000014.8 (55595935..55612148). Location: 14q22.3
OMIM
153619
3D Structure
ModBase 3D Structure for P17931
Immunogen
LGALS3 Mab is generated from mouse immunized with LGALS3 recombinant protein.
Conjugate
MaxLight550

Product Categories/Family for anti-LGALS3 antibody

Antibodies; Lamin; Laminin
Applications Tested/Suitable for anti-LGALS3 antibody
FLISA, Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-LGALS3 antibody
FLISA: 1:1000
IHC: 1:10-50
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-LGALS3 antibody

Salomonsson, E., et al. J. Biol. Chem. 285(45):35079-35091(2010) Debierre-Grockiego, F., et al. J. Biol. Chem. 285(43):32744-32750(2010) Zhou, J.Y., et al. J. Proteome Res. 9(10):5133-5141(2010) Markowska, A.I., et al. J. Exp. Med. 207(9):1981-1993(2010) Mazurek, N., et al. J. Biol. Chem. 275(46):36311-36315(2000)

Other Notes

Small volumes of anti-LGALS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LGALS3 purchase

MBS6209949 is an antibody targeting LGALS3. Also known as LGALS3, CT (LGALS3, MAC2, Galectin-3, 35kD lectin, Carbohydrate-binding protein 35, Galactose-specific lectin 3, Galactoside-binding protein, IgE-binding protein, L-31, Laminin-binding protein, Lectin L-29, Mac-2 antigen) (MaxLight 550). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for LGALS3. It may not necessarily be applicable to this product.

NCBI GI #
115430223
NCBI GeneID
3958
NCBI Accession #
NP_002297.2
UniProt Primary Accession #
P17931
UniProt Secondary Accession #
Q16005; Q6IBA7; Q96J47; B2RC38
UniProt Related Accession #
P17931
GenBank Nucleotide #
NM_002306.3
NCBI Official Full Name
galectin-3 isoform 1
NCBI Official Synonym Full Names
lectin, galactoside-binding, soluble, 3
NCBI Official Symbol
LGALS3
NCBI Official Synonym Symbols
L31; GAL3; MAC2; CBP35; GALBP; GALIG; LGALS2
UniProt Protein Name
Galectin-3
UniProt Synonym Protein Names
35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; Galactose-specific lectin 3; Galactoside-binding protein; GALBP; IgE-binding protein; L-31; Laminin-binding protein; Lectin L-29; Mac-2 antigen
UniProt Gene Name
LGALS3
UniProt Synonym Gene Names
MAC2; Gal-3; CBP 35; GALBP
UniProt Entry Name
LEG3_HUMAN
NCBI Protein Information
galectin-3; lectin L-29; 35 kDa lectin; MAC-2 antigen; IgE-binding protein; laminin-binding protein; galactose-specific lectin 3; carbohydrate-binding protein 35

UniProt Comments for LGALS3

Galectin-3: galactose-specific lectin which binds IgE. Expressed at a high level in the colonic epithelium. Also abundant in activated macrophages.

Protein type: Cell surface; Motility/polarity/chemotaxis; Extracellular matrix

Chromosomal Location of Human Ortholog: 14q22.3

Cellular Component: extracellular matrix; spliceosome; extracellular space; proteinaceous extracellular matrix; membrane; mitochondrial inner membrane; cytoplasm; plasma membrane; immunological synapse; nucleus; external side of plasma membrane

Molecular Function: protein binding; laminin binding; IgE binding; carbohydrate binding; chemoattractant activity

Biological Process: monocyte chemotaxis; neutrophil chemotaxis; extracellular matrix organization and biogenesis; epithelial cell differentiation; positive chemotaxis; RNA splicing; negative regulation of endocytosis; regulation of T cell proliferation; eosinophil chemotaxis; negative regulation of T cell receptor signaling pathway; innate immune response; mRNA processing; skeletal development; macrophage chemotaxis
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Research Articles on LGALS3

1. high circulating galectin-3 level may serve as a useful biomarker for predicting 30-day major adverse clinical outcome in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LGALS3 antibody

 Reference Product  PubMed Publications
 LGALS3BP antibody  >34 publications with LGALS3 and LGALS3BP
 GEMIN4 antibody  >5 publications with LGALS3 and GEMIN4
 MMP2 antibody  >2 publications with LGALS3 and MMP2
 LIM2 antibody  >2 publications with LGALS3 and LIM2
 SUFU antibody  >1 publications with LGALS3 and SUFU

Pathways associated with anti-LGALS3 antibody

 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Advanced Glycosylation Endproduct Receptor Signaling Pathway antibodies  Advanced Glycosylation Endproduct Receptor Signaling Pathway Diagram
 Hedgehog Signaling Events Mediated By Gli Proteins Pathway antibodies  Hedgehog Signaling Events Mediated By Gli Proteins Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram

Diseases associated with anti-LGALS3 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >783 publications with LGALS3 and Neoplasms
 Carcinoma Antibodies  >483 publications with LGALS3 and Carcinoma
 Adenocarcinoma Antibodies  >207 publications with LGALS3 and Adenocarcinoma
 Inflammation Antibodies  >192 publications with LGALS3 and Inflammation
 Adenoma Antibodies  >130 publications with LGALS3 and Adenoma
 Neoplasm Metastasis Antibodies  >129 publications with LGALS3 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >124 publications with LGALS3 and Disease Models, Animal
 Nervous System Diseases Antibodies  >121 publications with LGALS3 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >113 publications with LGALS3 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >100 publications with LGALS3 and Breast Neoplasms

Organs/Tissues associated with anti-LGALS3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >459 publications with LGALS3 and Blood
 Thyroid Antibodies  >267 publications with LGALS3 and Thyroid
 Vascular Antibodies  >137 publications with LGALS3 and Vascular
 Brain Antibodies  >112 publications with LGALS3 and Brain
 Lung Antibodies  >101 publications with LGALS3 and Lung
 Bone Antibodies  >99 publications with LGALS3 and Bone
 Liver Antibodies  >97 publications with LGALS3 and Liver
 Kidney Antibodies  >94 publications with LGALS3 and Kidney
 Heart Antibodies  >92 publications with LGALS3 and Heart
 Skin Antibodies  >74 publications with LGALS3 and Skin
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