Mouse Anti-COASY Monoclonal Antibody – Cat# MBS6210885

COASY Antibody – Mouse Monoclonal

Name: COASY Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6210885
Price: 1140 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6210885

Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. COASY is a bifunctional enzyme that catalyzes the 2 last steps in CoA synthesis. These activities are performed by 2 separate… More details

$1140 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

COASY, Monoclonal Antibody

Full Product Name

COASY (Bifunctional Coenzyme A Synthase, NBP, POV-2, Phosphopantetheine Adenylyltransferase, Dephospho-CoA Pyrophosphorylase, Pantetheine-phosphate Adenylyltransferase, Dephospho-CoA Kinase, Dephosphocoenzyme A Kinase, FLJ35179) (MaxLight 550)

Product Gene Name

anti-COASY antibody

Clonality

Monoclonal

Isotype

IgG1,k

Clone Number

1H6

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Specificity

Recognizes human COASY.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

65,339 Da

Immunogen

Full length recombinant corresponding to aa1-249 from COASY (AAH06354) with GST tag. MW of the GST tag alone is 26kD.

Immunogen Sequence

MLGNLLRPPYERPELPTCLYVIGLTGISGSGKSSIAQRLKGLGAFVIDSDHLGHRAYAPGGPAYQPVVEAFGTDILHKDGIINRKVLGSRVFGNKKQLKILTDIMWPIIAKLAREEMDRAVAEGKRVCVIDAAVLLEAGWQNLVHEVWTAVIPETEAVRRIVERDGLSEAAAQSRLQSQMSGQQLVEQSHVVLSTLWEPHITQRQVEKAWALLQKRIPKTHQALD

Conjugate

MaxLight550

Product Categories/Family for anti-COASY antibody

Antibodies; Enzymes; Synthase

Applications Tested/Suitable for anti-COASY antibody

FLISA, Western Blot (WB)

Application Notes for anti-COASY antibody

Applications are based on unconjugated antibody.

Other Notes

Small volumes of anti-COASY antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for COASY purchase

MBS6210885 is an antibody targeting COASY. Also known as COASY (Bifunctional Coenzyme A Synthase, NBP, POV-2, Phosphopantetheine Adenylyltransferase, Dephospho-CoA Pyrophosphorylase, Pantetheine-phosphate Adenylyltransferase, Dephospho-CoA Kinase, Dephosphocoenzyme A Kinase, FLJ35179) (MaxLight 550). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for COASY. It may not necessarily be applicable to this product.

NCBI GI #

13623498

NCBI GeneID

80347

NCBI Accession #

BC006354

NCBI Related Accession #

AAH06354

UniProt Secondary Accession #

Q6GS23; Q8NBM7; Q8NEW1; Q8WXD4; Q9NRM3; B2RA78; B4DLU0

UniProt Related Accession #

Q13057

NCBI Official Full Name

Homo sapiens Coenzyme A synthase, mRNA

NCBI Official Synonym Full Names

Coenzyme A synthase

NCBI Official Symbol

COASY

NCBI Official Synonym Symbols

NBP; DPCK; PPAT; UKR1; NBIA6; pOV-2

Protein Family

Bifunctional coenzyme A synthase

NCBI Protein Information

bifunctional coenzyme A synthase

NCBI Summary for COASY

Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms. [provided by RefSeq, Apr 2014]

Research Articles on COASY

1. Mutations in PANK2 and CoASY lead, respectively, to PKAN and CoPAN forms of Neurodegeneration with brain iron accumulation . Mutations in PLA2G6 lead to PLAN. Mutations in C19orf12 lead to MPAN

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-COASY antibody

Products by Pathway	Pathway Diagram
Coenzyme A Biosynthesis Pathway antibodies	Coenzyme A Biosynthesis Pathway Diagram
Coenzyme A Biosynthesis, Pantothenate => CoA Pathway antibodies	Coenzyme A Biosynthesis, Pantothenate => CoA Pathway Diagram
Coenzyme A Biosynthesis, Pantothenate => CoA Pathway antibodies	Coenzyme A Biosynthesis, Pantothenate => CoA Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Vitamins And Cofactors Pathway antibodies	Metabolism Of Vitamins And Cofactors Pathway Diagram
Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies	Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
Pantothenate And CoA Biosynthesis Pathway antibodies	Pantothenate And CoA Biosynthesis Pathway Diagram
Pantothenate And CoA Biosynthesis Pathway antibodies	Pantothenate And CoA Biosynthesis Pathway Diagram
Vitamin B5 (pantothenate) Metabolism Pathway antibodies	Vitamin B5 (pantothenate) Metabolism Pathway Diagram
Coenzyme A Biosynthesis Pathway antibodies	Coenzyme A Biosynthesis Pathway Diagram

Diseases associated with anti-COASY antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>1 publications with COASY and Neoplasms

Organs/Tissues associated with anti-COASY antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>2 publications with COASY and Brain