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WBSCR14 (MLXIPL) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS621105

ChREBP is a transcription factor involved in activating genes that encode enzymes of fatty acid biosynthesis in liver and adipose. This protein may have relevance to lipid metabolism, obesity, and type II diabetes. More details

$835 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
WBSCR14 (MLXIPL), Polyclonal Antibody
Full Product Name
WBSCR14 (Williams Beuren Syndrome Chromosome Region 14, Williams-Beuren Syndrome Chromosome Region 14 Protein, Carbohydrate Responsive Element Binding Protein, CHREBP, MIO, MLX Interacting Protein-like, MLXIPL, Mlx Interactor, MONDOB, WS Basic Helix-loop-
Product Gene Name
anti-MLXIPL antibody
Product Synonym Names
Anti -WBSCR14 (Williams Beuren Syndrome Chromosome Region 14, Williams-Beuren Syndrome Chromosome Region 14 Protein, Carbohydrate Responsive Element Binding Protein, CHREBP, MIO, MLX Interacting Protein-like, MLXIPL, Mlx Interactor, MONDOB, WS Basic Helix-loop-
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in Tris-citrate/phosphate, pH 7.5, 0.01% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human ChREBP. Species Crossreactivity: mouse (see Dentin et al) and rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
93,073 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (73007524..73038870, complement). Location: 7q11.23
OMIM
605678
3D Structure
ModBase 3D Structure for Q9NP71
Immunogen
Synthetic peptide corresponding to aa800-852 from the C-terminal of human ChREBP (NP_116569.1, isoform 1/alpha).

Product Categories/Family for anti-MLXIPL antibody

Antibodies; Abs to Disease Markers
Applications Tested/Suitable for anti-MLXIPL antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-MLXIPL antibody
Suitable for use in Chromatin Immunoprecipitation, Immunofluorescence, Western Blot and Immunohistochemistry.
Dilution: Immunofluorescence: 1:100-1:500
Immunohistochemistry: Formalin-fixed paraffin-embedded sections
Western Blot: 1:1000 detects a band at ~95kD

Testing Data of anti-MLXIPL antibody

Detection of ChREBP in 20ug of human hepatocyte lysate using MBS621105. 5-10 second film exposure.
Rabbit Anti-MLXIPL Polyclonal Antibody – Cat# MBS621105

Immunofluorescence (IF) of anti-MLXIPL antibody

Immunofluorescent staining of a human hepatocyte using MBS621105. Overlay staining of ChREBP (rhodamine red) and DAPI nuclear staining (blue).
Rabbit Anti-MLXIPL Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS621105

Testing Data of anti-MLXIPL antibody

Colon, Epithelium 40X using MBS621105
Rabbit Anti-MLXIPL Polyclonal Antibody, Testing Data – Cat# MBS621105

Testing Data of anti-MLXIPL antibody

Detection of ChREBP in liver nuclear extracts from well-fed rats. 7% SDS gel, 1:1,000 dilution of MBS621105.
Rabbit Anti-MLXIPL Polyclonal Antibody, Testing Data – Cat# MBS621105

Other Notes

Small volumes of anti-MLXIPL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MLXIPL purchase

MBS621105 is an antibody targeting MLXIPL. Also known as WBSCR14 (Williams Beuren Syndrome Chromosome Region 14, Williams-Beuren Syndrome Chromosome Region 14 Protein, Carbohydrate Responsive Element Binding Protein, CHREBP, MIO, MLX Interacting Protein-like, MLXIPL, Mlx Interactor, MONDOB, WS Basic Helix-loop-. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MLXIPL. It may not necessarily be applicable to this product.

NCBI GI #
14602439
NCBI GeneID
51085
NCBI Accession #
NP_116572.1
UniProt Primary Accession #
Q9NP71
UniProt Secondary Accession #
Q96E48; Q9BY03; Q9BY04; Q9BY05; Q9BY06; Q9Y2P3; C5HU02; C5HU03; C5HU04
UniProt Related Accession #
Q9NP71
GenBank Nucleotide #
NM_032954.2
NCBI Official Full Name
Williams-Beuren syndrome chromosomal region 14 protein isoform delta
NCBI Official Synonym Full Names
MLX interacting protein-like
NCBI Official Symbol
MLXIPL
NCBI Official Synonym Symbols
MIO; CHREBP; MONDOB; WBSCR14; WS-bHLH; bHLHd14
UniProt Protein Name
Williams-Beuren syndrome chromosomal region 14 protein
UniProt Synonym Protein Names
Class D basic helix-loop-helix protein 14; bHLHd14; MLX interactor; MLX-interacting protein-like; WS basic-helix-loop-helix leucine zipper protein
Protein Family
Carbohydrate-responsive element-binding protein
UniProt Gene Name
MLXIPL
UniProt Synonym Gene Names
BHLHD14; MIO; WBSCR14
UniProt Entry Name
WBS14_HUMAN
NCBI Protein Information
Williams-Beuren syndrome chromosomal region 14 protein; Mlx interactor; OTTHUMP00000160457; OTTHUMP00000160458; OTTHUMP00000211546; OTTHUMP00000211547; OTTHUMP00000225492; OTTHUMP00000225493; MLX-interacting protein-like; class D basic helix-loop-helix protein 14; Williams Beuren syndrome chromosome region 14; carbohydrate response element binding protein; carbohydrate-responsive element-binding protein; WS basic-helix-loop-helix leucine zipper protein; Williams-Beuren syndrome chromosome region 14 protein 1; Williams-Beuren syndrome chromosome region 14 protein 2

NCBI Summary for MLXIPL

This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. [provided by RefSeq]
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UniProt Comments for MLXIPL

ChREBP: Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. Binds DNA as a heterodimer with TCFL4/MLX. Expressed in liver, heart, kidney, cerebellum and intestinal tissues. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; cytosol; nucleus

Molecular Function: protein homodimerization activity; DNA binding; protein heterodimerization activity; transcription factor binding; transcription factor activity

Biological Process: positive regulation of fatty acid biosynthetic process; anatomical structure morphogenesis; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of cellular metabolic process; negative regulation of peptidyl-serine phosphorylation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of lipid biosynthetic process; glucose homeostasis; glucose mediated signaling; regulation of transcription from RNA polymerase II promoter; regulation of fatty acid biosynthetic process; regulation of transcription, DNA-dependent; fatty acid homeostasis; positive regulation of glycolysis; positive regulation of cell proliferation; energy reserve metabolic process; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent

Disease: Williams-beuren Syndrome
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Research Articles on MLXIPL

1. ChREBP is a critical and direct mediator of glucose repression of PPARalpha gene expression in pancreatic beta-cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MLXIPL antibody

 Reference Product  PubMed Publications
 MLX antibody  >9 publications with MLXIPL and MLX
 NIF3L1 antibody  >1 publications with MLXIPL and NIF3L1

Pathways associated with anti-MLXIPL antibody

 Products by Pathway  Pathway Diagram
 AMPK Inhibits ChREBP Transcriptional Activation Activity Pathway antibodies  AMPK Inhibits ChREBP Transcriptional Activation Activity Pathway Diagram
 ChREBP Activates Metabolic Gene Expression Pathway antibodies  ChREBP Activates Metabolic Gene Expression Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
 PKA-mediated Phosphorylation Of Key Metabolic Factors Pathway antibodies  PKA-mediated Phosphorylation Of Key Metabolic Factors Pathway Diagram
 PP2A-mediated Dephosphorylation Of Key Metabolic Factors Pathway antibodies  PP2A-mediated Dephosphorylation Of Key Metabolic Factors Pathway Diagram

Diseases associated with anti-MLXIPL antibody

 Disease Name  Pubmed Publications
 Obesity Antibodies  >8 publications with MLXIPL and Obesity
 Insulin Resistance Antibodies  >6 publications with MLXIPL and Insulin Resistance
 Hyperinsulinism Antibodies  >5 publications with MLXIPL and Hyperinsulinism
 Fatty Liver Antibodies  >5 publications with MLXIPL and Fatty Liver
 Hypertriglyceridemia Antibodies  >4 publications with MLXIPL and Hypertriglyceridemia
 Myocardial Ischemia Antibodies  >4 publications with MLXIPL and Myocardial Ischemia
 Congenital Abnormalities Antibodies  >4 publications with MLXIPL and Congenital Abnormalities
 Dyslipidemias Antibodies  >4 publications with MLXIPL and Dyslipidemias
 Coronary Artery Disease Antibodies  >4 publications with MLXIPL and Coronary Artery Disease
 Coronary Disease Antibodies  >4 publications with MLXIPL and Coronary Disease

Organs/Tissues associated with anti-MLXIPL antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >12 publications with MLXIPL and Liver
 Lung Antibodies  >3 publications with MLXIPL and Lung
 Brain Antibodies  >3 publications with MLXIPL and Brain
 Nerve Antibodies  >2 publications with MLXIPL and Nerve
 Pancreas Antibodies  >2 publications with MLXIPL and Pancreas
 Kidney Antibodies  >1 publications with MLXIPL and Kidney
 Adipose Tissue Antibodies  >1 publications with MLXIPL and Adipose Tissue
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