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DTX3 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6211226

DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]). More details

$1140 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DTX3, Monoclonal Antibody
Full Product Name
DTX3 (RNF154, Probable E3 Ubiquitin-protein Ligase DTX3, Protein Deltex-3, RING Finger Protein 154, FLJ34766, MGC138863, MGC138864) (MaxLight 550)
Product Gene Name
Clonality
Monoclonal
Isotype
IgG3, lambda
Clone Number
4F10
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human DTX3.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
OMIM
613142
3D Structure
ModBase 3D Structure for Q8N9I9
Immunogen
Partial recombinant protein corresponding to aa201-301 from human DTX3 (NP_848597) with GST tag. MW of the GST tag alone is 26kD.
Immunogen Sequence
MCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGTIVIQYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTSMTT
Conjugate
MaxLight550

Product Categories/Family for anti-DTX3 antibody

Applications Tested/Suitable for anti-DTX3 antibody
FLISA
Application Notes for anti-DTX3 antibody
Applications are based on unconjugated antibody.

Other Notes

Small volumes of anti-DTX3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DTX3 purchase

MBS6211226 is an antibody targeting DTX3. Also known as DTX3 (RNF154, Probable E3 Ubiquitin-protein Ligase DTX3, Protein Deltex-3, RING Finger Protein 154, FLJ34766, MGC138863, MGC138864) (MaxLight 550). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for DTX3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
probable E3 ubiquitin-protein ligase DTX3 isoform a
NCBI Official Synonym Full Names
deltex E3 ubiquitin ligase 3
NCBI Official Symbol
DTX3
NCBI Official Synonym Symbols
RNF154; deltex3
UniProt Protein Name
Probable E3 ubiquitin-protein ligase DTX3
UniProt Synonym Protein Names
Protein deltex-3; Deltex3; RING finger protein 154
UniProt Gene Name
DTX3
UniProt Synonym Gene Names
RNF154; Deltex3
UniProt Entry Name
DTX3_HUMAN
NCBI Protein Information
probable E3 ubiquitin-protein ligase DTX3

UniProt Comments for DTX3

DTX3: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Belongs to the Deltex family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ligase; EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: cytoplasm

Molecular Function: zinc ion binding; ligase activity

Biological Process: Notch signaling pathway; protein ubiquitination
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-DTX3 antibody

Organs/Tissues associated with anti-DTX3 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1 publications with DTX3 and Liver
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