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Tankyrase 2 (TNKS2) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS621201

Tankyrase (TRF1-interacting ankyrin-related ADP-ribose polymerase, Tankyase 1, TANK1, TNKS1) is a protein with homology to ankyrins as well as to the catalytic domain of poly (adenosine diphosphate-ribose) polymerase (PARP) (1). Tankyrase localizes to… More details

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Product Overview

Online Datasheet in PDF
Product Name
Tankyrase 2 (TNKS2), Polyclonal Antibody
Full Product Name
Tankyrase 2 (TNKS2, Tankyrase, TRF1-interacting Ankyrin-related ADP-ribose polymerase 2, PARP-5b, PARP-5c, PARP5B, PARP5C, TANK2, TNKL, Tankyrase 2)
Product Gene Name
anti-TNKS2 antibody
Product Synonym Names
Anti -Tankyrase 2 (TNKS2, Tankyrase, TRF1-interacting Ankyrin-related ADP-ribose polymerase 2, PARP-5b, PARP-5c, PARP5B, PARP5C, TANK2, TNKL, Tankyrase 2)
Clonality
Polyclonal
Host
Goat
Species Reactivity
Human
Form/Format
Supplied as a liquid in Tris, pH 7.2, 0.5% BSA, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Specificity
Recognizes human Tankyrase 2 at ~125kD. Species Sequence Homology: mouse and canine
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Molecular Weight
126,918 Da
Chromosome Location
Chromosome: 10; NC_000010.10 (93558151..93625232). Location: 10q23.3
OMIM
607128
3D Structure
ModBase 3D Structure for Q9H2K2
Immunogen
Synthetic peptide with sequence C-HRRKEVSEENHNH, from the internal region of human Tankyrase 2 (NP_079511.1).
Positive Control
Jurkat cell line lysates

Product Categories/Family for anti-TNKS2 antibody

Antibodies; Abs to Enzymes; Polymerase
Applications Tested/Suitable for anti-TNKS2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-TNKS2 antibody
Suitable for use in Peptide ELISA and Western Blot.
Dilution: Peptide ELISA: 1:16,000
Western Blot: 0.5-1.5ug/ml. Observed band at ~125kD. An additional band of unknown identity was observed at ~45kD.

Chemiluminescence of anti-TNKS2 antibody

MBS621201 (0.5ug/ml) staining of Jurkat lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-TNKS2 Polyclonal Antibody – Cat# MBS621201

Other Notes

Small volumes of anti-TNKS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNKS2 purchase

MBS621201 is an antibody targeting TNKS2. Also known as Tankyrase 2 (TNKS2, Tankyrase, TRF1-interacting Ankyrin-related ADP-ribose polymerase 2, PARP-5b, PARP-5c, PARP5B, PARP5C, TANK2, TNKL, Tankyrase 2). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for TNKS2. It may not necessarily be applicable to this product.

NCBI GI #
13376842
NCBI GeneID
80351
NCBI Accession #
NP_079511.1
UniProt Primary Accession #
Q9H2K2
UniProt Secondary Accession #
Q9H8F2; Q9HAS4
UniProt Related Accession #
Q9H2K2
GenBank Nucleotide #
NM_025235.3
NCBI Official Full Name
tankyrase-2
NCBI Official Synonym Full Names
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
NCBI Official Symbol
TNKS2
NCBI Official Synonym Symbols
TNKL; TANK2; pART6; PARP5B; PARP5C; PARP-5b; PARP-5c
UniProt Protein Name
Tankyrase-2
UniProt Synonym Protein Names
Poly [ADP-ribose] polymerase 5B; TNKS-2; TRF1-interacting ankyrin-related ADP-ribose polymerase 2; Tankyrase II; Tankyrase-like protein; Tankyrase-related protein
Protein Family
Tankyrase
UniProt Gene Name
TNKS2
UniProt Synonym Gene Names
PARP5B; TANK2; TNKL
UniProt Entry Name
TNKS2_HUMAN
NCBI Protein Information
tankyrase-2; TNKS-2; tankyrase 2; tankyrase II; OTTHUMP00000020090; tankyrase-like protein; tankyrase-related protein; poly [ADP-ribose] polymerase 5B; TRF1-interacting ankyrin-related ADP-ribose polymerase 2

UniProt Comments for TNKS2

TNKS2: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP- ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.

Protein type: EC 2.4.2.30; Transferase; Nuclear envelope

Chromosomal Location of Human Ortholog: 10q23.3

Cellular Component: Golgi membrane; pericentriolar material; nuclear chromosome, telomeric region; perinuclear region of cytoplasm; cytoplasm; nuclear envelope; cytosol; nucleus

Molecular Function: protein binding; enzyme binding; metal ion binding; NAD+ ADP-ribosyltransferase activity

Biological Process: protein amino acid ADP-ribosylation; Wnt receptor signaling pathway; protein polyubiquitination; multicellular organism growth; regulation of multicellular organism growth; positive regulation of telomere maintenance via telomerase
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Research Articles on TNKS2

1. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TNKS2 antibody

 Reference Product  PubMed Publications
 TNKS antibody  >11 publications with TNKS2 and TNKS
 TERF1 antibody  >4 publications with TNKS2 and TERF1

Diseases associated with anti-TNKS2 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >3 publications with TNKS2 and Carcinoma
 Breast Neoplasms Antibodies  >2 publications with TNKS2 and Breast Neoplasms
 Pancreatic Neoplasms Antibodies  >2 publications with TNKS2 and Pancreatic Neoplasms
 Skin Neoplasms Antibodies  >1 publications with TNKS2 and Skin Neoplasms
 Neoplasm Metastasis Antibodies  >1 publications with TNKS2 and Neoplasm Metastasis
 Necrosis Antibodies  >1 publications with TNKS2 and Necrosis
 Diabetes Mellitus, Type 2 Antibodies  >1 publications with TNKS2 and Diabetes Mellitus, Type 2
 Inflammation Antibodies  >1 publications with TNKS2 and Inflammation
 Kidney Neoplasms Antibodies  >1 publications with TNKS2 and Kidney Neoplasms

Organs/Tissues associated with anti-TNKS2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with TNKS2 and Blood
 Kidney Antibodies  >2 publications with TNKS2 and Kidney
 Lymph Antibodies  >1 publications with TNKS2 and Lymph
 Lymph Node Antibodies  >1 publications with TNKS2 and Lymph Node
 Skin Antibodies  >1 publications with TNKS2 and Skin
 Vascular Antibodies  >1 publications with TNKS2 and Vascular
 Embryonic Tissue Antibodies  >1 publications with TNKS2 and Embryonic Tissue
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