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IQGAP2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6212106

This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several… More details

$1140 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IQGAP2, Monoclonal Antibody
Full Product Name
IQGAP2 (Ras GTPase-activating-like Protein IQGAP2) (MaxLight 550)
Product Gene Name
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
1B10
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human IQGAP2.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
OMIM
605401
3D Structure
ModBase 3D Structure for Q13576
Immunogen
Partial recombinant corresponding to aa343-449 from human IQGAP2 (NP_006624) with GST tag. MW of the GST tag alone is 26kD.
Immunogen Sequence
MYQNELFNLQKQNTMNYLAHEELLIAVEMLSAVALLNQALESNDLVSVQNQLRSPAIGLNNLDKAYVERYANTLLSVKLEVLSQGQDNLSWNEIQNCIDMVNAQIQE
Conjugate
MaxLight550

Product Categories/Family for anti-IQGAP2 antibody

Applications Tested/Suitable for anti-IQGAP2 antibody
FLISA, Western Blot (WB)
Application Notes for anti-IQGAP2 antibody
Applications are based on unconjugated antibody.

Other Notes

Small volumes of anti-IQGAP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IQGAP2 purchase

MBS6212106 is an antibody targeting IQGAP2. Also known as IQGAP2 (Ras GTPase-activating-like Protein IQGAP2) (MaxLight 550). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for IQGAP2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
ras GTPase-activating-like protein IQGAP2 isoform 1
NCBI Official Synonym Full Names
IQ motif containing GTPase activating protein 2
NCBI Official Symbol
IQGAP2
UniProt Protein Name
Ras GTPase-activating-like protein IQGAP2
UniProt Gene Name
IQGAP2
UniProt Entry Name
IQGA2_HUMAN
NCBI Protein Information
ras GTPase-activating-like protein IQGAP2

NCBI Summary for IQGAP2

This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been found to play a role in regulating innate antiviral responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
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UniProt Comments for IQGAP2

IQGAP2: Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin. Isoform 2 expression is enhanced in testis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein regulator, misc.; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q13.3

Cellular Component: filamentous actin; microtubule; microvillus; cell surface; lamellipodium; cytoplasm; actin cytoskeleton; filopodium

Molecular Function: calmodulin binding; actin filament binding; phosphatidylinositol-3,4,5-triphosphate binding; Rho GTPase binding; Rac GTPase binding; actin binding; GTPase inhibitor activity

Biological Process: small GTPase mediated signal transduction; negative regulation of catalytic activity; signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IQGAP2 antibody

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