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JARID1B Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6212151

MBS6212151 is an antibody targeting JARID1B. Also known as JARID1B (KDM5B, PLU1, RBBP2H1, Lysine-specific Demethylase 5B, Cancer/Testis Antigen 31, Histone Demethylase JARID1B, Jumonji/ARID Domain-containing Protein 1B, PLU-1, Retinoblastoma-binding Protein 2… More details

$1140 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
JARID1B, Monoclonal Antibody
Full Product Name
JARID1B (KDM5B, PLU1, RBBP2H1, Lysine-specific Demethylase 5B, Cancer/Testis Antigen 31, Histone Demethylase JARID1B, Jumonji/ARID Domain-containing Protein 1B, PLU-1, Retinoblastoma-binding Protein 2 Homolog 1, FLJ10538, FLJ12459, FLJ12491, FLJ16281, FLJ
Product Gene Name
anti-JARID1B antibody
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
1G10
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human JARID1B.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
175,658 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (202696532..202777549, complement). Location: 1q32.1
OMIM
AJ132440 mRNA
3D Structure
ModBase 3D Structure for Q9UGL1
Immunogen
Partial recombinant protein corresponding to aa231-319 from human JARID1B (NP_006609) with GST tag. MW of the GST tag alone is 26kD.
Immunogen Sequence
AKRMRAEAMNIKIEPEETTEARTHNLRRRMGCPTPKCENEKEMKSSIKQEPIERKDYIVENEKEKPKSRSKKATNAVDLYVCLLCGSGN
Conjugate
MaxLight550

Product Categories/Family for anti-JARID1B antibody

Antibodies; Enzymes; Demethylase
Applications Tested/Suitable for anti-JARID1B antibody
FLISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-JARID1B antibody
IF: 10ug/ml
Applications are based on unconjugated antibody.

Other Notes

Small volumes of anti-JARID1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for JARID1B. It may not necessarily be applicable to this product.

NCBI GI #
57242796
NCBI GeneID
10765
NCBI Accession #
NP_006609
UniProt Primary Accession #
Q9UGL1
UniProt Secondary Accession #
O95811; Q15752; Q9Y3Q5
UniProt Related Accession #
O94800; Q6UGB8; Q9NSZ7; Q9UFC7; Q9UFD3; Q9UGL1; Q9UIW7
GenBank Nucleotide #
NM_006618
NCBI Official Full Name
lysine-specific demethylase 5B
NCBI Official Synonym Full Names
lysine (K)-specific demethylase 5B
NCBI Official Symbol
KDM5B
NCBI Official Synonym Symbols
CT31; PLU1; PUT1; PLU-1; JARID1B; FLJ10538; FLJ12459; FLJ12491; FLJ16281; FLJ23670; RBBP2H1A
UniProt Protein Name
Lysine-specific demethylase 5B
UniProt Synonym Protein Names
Cancer/testis antigen 31; CT31; Histone demethylase JARID1B; Jumonji/ARID domain-containing protein 1B; PLU-1; Retinoblastoma-binding protein 2 homolog 1; RBP2-H1
Protein Family
Lysine-specific demethylase
UniProt Gene Name
KDM5B
UniProt Synonym Gene Names
JARID1B; PLU1; RBBP2H1; CT31; RBP2-H1
NCBI Protein Information
lysine-specific demethylase 5B; RBP2-H1; OTTHUMP00000038815; OTTHUMP00000038816; OTTHUMP00000197658; cancer/testis antigen 31; histone demethylase JARID1B; putative DNA/chromatin binding motif; jumonji, AT rich interactive domain 1B; jumonji/ARID domain-c

UniProt Comments for JARID1B

JARID1B: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7. Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer. Belongs to the JARID1 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cancer Testis Antigen (CTA); Demethylase; EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: histone demethylase activity; histone demethylase activity (H3-K4 specific); protein binding; transcription corepressor activity; transcription factor activity
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-JARID1B antibody

 Reference Product  PubMed Publications
 PAX9 antibody  >3 publications with JARID1B and PAX9
 FOXG1 antibody  >1 publications with JARID1B and FOXG1

Diseases associated with anti-JARID1B antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >19 publications with JARID1B and Neoplasms
 Breast Neoplasms Antibodies  >9 publications with JARID1B and Breast Neoplasms
 Melanoma Antibodies  >7 publications with JARID1B and Melanoma
 Mammary Neoplasms, Animal Antibodies  >3 publications with JARID1B and Mammary Neoplasms, Animal
 Skin Neoplasms Antibodies  >2 publications with JARID1B and Skin Neoplasms
 Neoplasm Metastasis Antibodies  >2 publications with JARID1B and Neoplasm Metastasis
 Lung Diseases Antibodies  >2 publications with JARID1B and Lung Diseases
 Carcinoma, Ductal, Breast Antibodies  >1 publications with JARID1B and Carcinoma, Ductal, Breast
 Prostatic Diseases Antibodies  >1 publications with JARID1B and Prostatic Diseases
 Genetic Diseases, Inborn Antibodies  >1 publications with JARID1B and Genetic Diseases, Inborn

Organs/Tissues associated with anti-JARID1B antibody

 Organ/Tissue Name  Pubmed Publications
 Mammary Gland Antibodies  >6 publications with JARID1B and Mammary Gland
 Testis Antibodies  >5 publications with JARID1B and Testis
 Embryonic Tissue Antibodies  >3 publications with JARID1B and Embryonic Tissue
 Brain Antibodies  >3 publications with JARID1B and Brain
 Lung Antibodies  >2 publications with JARID1B and Lung
 Bone Antibodies  >2 publications with JARID1B and Bone
 Blood Antibodies  >2 publications with JARID1B and Blood
 Skin Antibodies  >2 publications with JARID1B and Skin
 Kidney Antibodies  >1 publications with JARID1B and Kidney
 Prostate Antibodies  >1 publications with JARID1B and Prostate
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