Goat Anti-MRC2 Polyclonal Antibody – Cat# MBS621269

Detection of Mrc2 with MBS621269. Cell lysates were resolved by SDS-PAGE, transferred to an Immobilon-P membrane and immunoblotted with 1ug/ml goat anti-hMrc2.

MRC2 Antibody – Goat Polyclonal

Name: MRC2 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS621269
Price: 1090 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS621269

Mrc2 (C-type Mannose Receptor 2; also MMR2, Endocytic Receptor 180 and uPARAP) is a 180-200kD member of the macrophage mannose receptor family of proteins. It is widely expressed, being found on fibroblasts, monocytes/macrophages, endothelial cells,… More details

$1090 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Mrc2, Polyclonal Antibody

Full Product Name

Mrc2 (Macrophage Mannose Receptor 2, uPARAP, Endo180)

Product Gene Name

anti-MRC2 antibody

Product Synonym Names

Anti -Mrc2 (Macrophage Mannose Receptor 2, uPARAP, Endo180)

Clonality

Polyclonal

Isotype

IgG

Host

Goat

Species Reactivity

Human

Form/Format

Supplied as a lyophilized powder from 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with sterile PBS, sterile 40-50% glycerol.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes human Mrc2. Species sequence homology: mouse (87%).

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS, sterile 40-50% glycerol, aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

166,674 Da

Chromosome Location

Chromosome: 17; NC_000017.10 (60704762..60770953). Location: 17q23.2

OMIM

612264

3D Structure

ModBase 3D Structure for Q9UBG0

Immunogen

E. coli-derived, recombinant human Mrc2 (aa800-1059).

Product Categories/Family for anti-MRC2 antibody

Antibodies; Abs to Receptors

Applications Tested/Suitable for anti-MRC2 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-MRC2 antibody

Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1ug/ml
ELISA: 0.5-1ug/ml

Other Notes

Small volumes of anti-MRC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MRC2 purchase

MBS621269 is an antibody targeting MRC2. Also known as Mrc2 (Macrophage Mannose Receptor 2, uPARAP, Endo180). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for MRC2. It may not necessarily be applicable to this product.

NCBI GI #

119614748

NCBI GeneID

9902

UniProt Primary Accession #

Q9UBG0

UniProt Secondary Accession #

Q7LGE7; Q9Y5P9; A6H8K4; D3DU08

UniProt Related Accession #

Q9UBG0

NCBI Official Full Name

mannose receptor, C type 2, isoform CRA_a

NCBI Official Synonym Full Names

mannose receptor, C type 2

NCBI Official Symbol

MRC2

NCBI Official Synonym Symbols

CD280; UPARAP; CLEC13E; ENDO180; FLJ35911; KIAA0709

UniProt Protein Name

C-type mannose receptor 2

UniProt Synonym Protein Names

C-type lectin domain family 13 member E; Endocytic receptor 180; Macrophage mannose receptor 2; Urokinase-type plasminogen activator receptor-associated protein

Protein Family

C-type mannose receptor

UniProt Gene Name

MRC2

UniProt Synonym Gene Names

CLEC13E; ENDO180; KIAA0709; UPARAP

UniProt Entry Name

MRC2_HUMAN

NCBI Protein Information

C-type mannose receptor 2; endocytic receptor 180; UPAR-associated protein; macrophage mannose receptor 2; urokinase receptor-associated protein; C-type lectin domain family 13 member E; endocytic receptor (macrophage mannose receptor family); urokinase plasminogen activator receptor-associated protein; urokinase-type plasminogen activator receptor-associated protein

NCBI Summary for MRC2

MRC2 is a recycling endocytic receptor that functions in cell motility and remodeling of the extracellular matrix by promoting cell migration and uptake of collagens for intracellular degradation (Wienke et al., 2007 [PubMed 17974964]).[supplied by OMIM]

UniProt Comments for MRC2

MRC2: May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs).

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q23.2

Cellular Component: focal adhesion; membrane; integral to membrane

Molecular Function: collagen binding; protein binding; carbohydrate binding

Biological Process: osteoblast differentiation; collagen catabolic process; endocytosis

Research Articles on MRC2

1. fibrillar collagen deposition and the collagen internalization receptor endo180 have roles in glioma invasion

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MRC2 antibody

Products by Pathway	Pathway Diagram
Phagosome Pathway antibodies	Phagosome Pathway Diagram
Phagosome Pathway antibodies	Phagosome Pathway Diagram
Tuberculosis Pathway antibodies	Tuberculosis Pathway Diagram
Tuberculosis Pathway antibodies	Tuberculosis Pathway Diagram

Diseases associated with anti-MRC2 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>12 publications with MRC2 and Neoplasms
Breast Neoplasms Antibodies	>5 publications with MRC2 and Breast Neoplasms
Neoplasm Invasiveness Antibodies	>4 publications with MRC2 and Neoplasm Invasiveness
Fibrosis Antibodies	>3 publications with MRC2 and Fibrosis
Liver Diseases Antibodies	>2 publications with MRC2 and Liver Diseases
Adenocarcinoma Antibodies	>2 publications with MRC2 and Adenocarcinoma
Head and Neck Neoplasms Antibodies	>1 publications with MRC2 and Head and Neck Neoplasms
Nervous System Diseases Antibodies	>1 publications with MRC2 and Nervous System Diseases
Intestinal Diseases Antibodies	>1 publications with MRC2 and Intestinal Diseases
Carcinoma, Hepatocellular Antibodies	>1 publications with MRC2 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-MRC2 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>6 publications with MRC2 and Blood
Skin Antibodies	>5 publications with MRC2 and Skin
Vascular Antibodies	>4 publications with MRC2 and Vascular
Liver Antibodies	>3 publications with MRC2 and Liver
Muscle Antibodies	>3 publications with MRC2 and Muscle
Lung Antibodies	>2 publications with MRC2 and Lung
Bone Antibodies	>2 publications with MRC2 and Bone
Kidney Antibodies	>2 publications with MRC2 and Kidney
Mammary Gland Antibodies	>2 publications with MRC2 and Mammary Gland
Embryonic Tissue Antibodies	>2 publications with MRC2 and Embryonic Tissue