Clostridium Botulinum Neurotoxin Type C1 Heavy Chain Antibody – Sheep Polyclonal

BoNT-C1 (Botulinum Neurotoxin Type C1 [Heavy Chain]) is a 100kD C-terminal fragment of the C1 Clostridum botulinum neurotoxin (holo)precursor. It constitutes a nonenzymatic part of a Zn 2+ -dependent M27 family endoprotease that potently blocks neurosecretion. The inactive 1291aa, 150kD C1 precursor is cleaved between Lys449Thr450 to generate a heterodimeric toxin held together by a preexisting interchain disulfide bond between Cys437 and Cys453. The 100kD C-terminus (heavy chain) acts as a ligand for neuronal membrane ecto-acceptors, its inducing internalization with translocation. The 50kD N-terminal light chain acts as an intracellular peptidase that cleaves SNAP-25 and syntaxin. This is suggested to block noradrenalin release from a readily releasable pool of vesicles. Over aa866-1291, the C1 heavy chain shares less than 40% aa identity with the D-type neurotoxin heavy chain.

Small volumes of anti-Clostridium botulinum Neurotoxin Type C1 Heavy Chain antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS621273 is an antibody targeting Clostridium botulinum Neurotoxin Type C1 Heavy Chain. Also known as Clostridium botulinum Neurotoxin Type C1 Heavy Chain (BoNT-C1). Host: Sheep.