• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CERS1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS621361

This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved… More details

$835 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LASS1 (CERS1), Polyclonal Antibody
Full Product Name
LASS1 (CerS1, LAG1, MGC90349, UOG1, LAG1 longevity assurance homolog 1, Longevity assurance gene 1 protein homolog 1, Protein UOG-1)
Product Gene Name
anti-CERS1 antibody
Product Synonym Names
Anti -LASS1 (CerS1, LAG1, MGC90349, UOG1, LAG1 longevity assurance homolog 1, Longevity assurance gene 1 protein homolog 1, Protein UOG-1)
Clonality
Polyclonal
Host
Goat
Species Reactivity
Human
Form/Format
Supplied as a liquid in Tris, pH 7.2, 0.5% BSA, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Specificity
Recognizes both reported isoforms (NP_067090.1 and NP_937850.1) of human Lass1 at ~37kD. Species sequence homology: mouse, rat, bovine.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
39,536 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (18979361..19006953, complement). Location: 19p12
OMIM
606919
3D Structure
ModBase 3D Structure for P27544
Immunogen
Synthetic peptide with sequence C-KDLREYDTAEAQ, from the internal region of human Lass1.
Positive Control
Human Brain (Cerebellum, Cerebral Cortex and Frontal Cortex) lysates

Product Categories/Family for anti-CERS1 antibody

Antibodies; Abs to Growth Factors; Cytokines
Applications Tested/Suitable for anti-CERS1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CERS1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:64000
Western Blot: 1-3ug/ml

Chemiluminescence of anti-CERS1 antibody

MBS621361 (1ug/ml) staining of Frontal Cortex lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-CERS1 Polyclonal Antibody – Cat# MBS621361

Other Notes

Small volumes of anti-CERS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CERS1 purchase

MBS621361 is an antibody targeting CERS1. Also known as LASS1 (CerS1, LAG1, MGC90349, UOG1, LAG1 longevity assurance homolog 1, Longevity assurance gene 1 protein homolog 1, Protein UOG-1). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for CERS1. It may not necessarily be applicable to this product.

NCBI GI #
38176296
NCBI GeneID
10715
NCBI Accession #
NP_937850.1
UniProt Primary Accession #
P27544
UniProt Related Accession #
P27544; Q5XG75
GenBank Nucleotide #
NM_198207.2
NCBI Official Full Name
LAG1 longevity assurance homolog 1 isoform 2
NCBI Official Synonym Full Names
ceramide synthase 1
NCBI Official Symbol
CERS1
NCBI Official Synonym Symbols
LAG1; UOG1; LASS1; MGC90349
UniProt Protein Name
LAG1 longevity assurance homolog 1
UniProt Synonym Protein Names
Longevity assurance gene 1 protein homolog 1; Protein UOG-1
Protein Family
Ceramide synthase
UniProt Gene Name
LASS1
UniProt Synonym Gene Names
LAG1; UOG1
UniProt Entry Name
LASS1_HUMAN
NCBI Protein Information
LAG1 longevity assurance homolog 1; protein UOG-1; upstream of GDF1; LAG1 homolog, ceramide synthase 1; longevity assurance gene 1 protein homolog 1; longevity assurance (LAG1, S. cerevisiae) homolog 1

UniProt Comments for CERS1

LASS1: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 19p12

Cellular Component: Golgi membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bound organelle; endoplasmic reticulum; integral to membrane

Molecular Function: sphingosine N-acyltransferase activity

Biological Process: negative regulation of telomerase activity; sphingolipid metabolic process; sphingolipid biosynthetic process; ceramide biosynthetic process

Disease: Epilepsy, Progressive Myoclonic, 8
Show more

Research Articles on CERS1

1. The variation in LASS1 is functional, causing enhanced expression of the gene, and it contributes to healthy aging and greater survival in the tenth decade of life.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CERS1 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram

Organs/Tissues associated with anti-CERS1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with CERS1 and Brain
 Nerve Antibodies  >2 publications with CERS1 and Nerve
 Lung Antibodies  >1 publications with CERS1 and Lung
 Skin Antibodies  >1 publications with CERS1 and Skin
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000