ARAP1 Antibody – Goat Polyclonal

The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

CENTD2: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; Motility/polarity/chemotaxis; GAPs, ARF

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: Golgi apparatus; plasma membrane; trans-Golgi network; cytoplasmic vesicle; cytosol

Molecular Function: protein binding; phosphatidylinositol-3,4,5-triphosphate binding; zinc ion binding; type 1 angiotensin receptor binding

Biological Process: positive regulation of filopodium formation; regulation of cell shape; regulation of small GTPase mediated signal transduction; negative regulation of stress fiber formation; small GTPase mediated signal transduction; regulation of cell motility; positive regulation of receptor recycling; actin filament reorganization during cell cycle