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MAGE-1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6215000

MBS6215000 is an antibody targeting MAGE-1. Also known as MAGE-1 (Melanoma-associated Antigen 1, MAGE-1 Antigen, Cancer/testis Antigen, CTA) (MaxLight 550). Reactive in Canine, Human, Rat. Host: Mouse. More details

$1105 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MAGE-1, Monoclonal Antibody
Full Product Name
MAGE-1 (Melanoma-associated Antigen 1, MAGE-1 Antigen, Cancer/testis Antigen, CTA) (MaxLight 550)
Product Gene Name
anti-MAGE-1 antibody
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
MA454
Host
Mouse
Species Reactivity
Canine, Human, Rat
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Protein G Affinity Chromatography
Specificity
Recognizes human MAGE-1. Species Crossreactivity: rat and canine.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
34,342 Da
OMIM
300016
3D Structure
ModBase 3D Structure for P43355
Immunogen
Recombinant protein corresponding to full length human MAGE-1.
Conjugate
MaxLight550
Positive Control
Melanoma cell lines. Melanomas, gliomas, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, and renal cell carcinomas.

Product Categories/Family for anti-MAGE-1 antibody

Antibodies; Cancer Markers
Applications Tested/Suitable for anti-MAGE-1 antibody
Flow Cytometry (FC/FACS), FLISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-MAGE-1 antibody
IP: 1-2ug/500ug protein lysate
IF: 1-2ug/ml
FC/FACS: 0.5-1ug/10e6 cells
Western Blot: 0.5-1ug/ml
Applications are based on unconjugated antibody.

Product References and Citations for anti-MAGE-1 antibody

1. Ma ZY, Khatlani TS, Sasaki K, Okuda M, Inokuma H, Onishi T. Identification of feline MAGE-1 gene product by monoclonal antibodies. Tissue Antigens. 2002 Aug;60(2):133-8. PMID: 12392507 2. Laduron S, Deplus R, Zhou S, Kholmanskikh O, Godelaine D, De Smet C, Hayward SD, Fuks F, Boon T, De Plaen E. MAGE-A1 interacts with adaptor SKIP and the deacetylase HDAC1 to repress transcription. Nucleic Acids Res. 2004 Aug 17;32(14):4340-50. Print 2004. PMID: 15316101 3. Loriot A, De Plaen E, Boon T, De Smet C. Transient down-regulation of DNMT1 methyltransferase leads to activation and stable hypomethylation of MAGE-A1 in melanoma cells. J Biol Chem. 2006 Apr 14;281(15):10118-26. Epub 2006 Feb 22. PMID: 16497664 4. Pereira CM, Gomes CC, De Fatima Correia Silva J, Bucciarelli Rodriguez M, Barbosa AA, Gomez RS. Evaluation of MAGE A1 in oral squamous cell carcinoma. Oncol Rep. 2012 Jun;27(6):1843-8. doi: 10.3892/or.2012.1736. Epub 2012 Mar 19. PMID: 22447174

Other Notes

Small volumes of anti-MAGE-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MAGE-1. It may not necessarily be applicable to this product.

NCBI GI #
148276977
NCBI GeneID
4100
NCBI Accession #
NP_004979
UniProt Primary Accession #
P43355
UniProt Secondary Accession #
O00346; B2RC81
UniProt Related Accession #
P43355; AAB33086
GenBank Nucleotide #
NM_004988
NCBI Official Full Name
melanoma-associated antigen 1
NCBI Official Synonym Full Names
melanoma antigen family A1
NCBI Official Symbol
MAGEA1
NCBI Official Synonym Symbols
CT1.1; MAGE1
UniProt Protein Name
Melanoma-associated antigen 1
UniProt Synonym Protein Names
Antigen MZ2-E; Cancer/testis antigen 1.1; CT1.1; MAGE-1 antigen
Protein Family
Melanoma-associated antigen
UniProt Gene Name
MAGEA1
UniProt Synonym Gene Names
MAGE1; MAGE1A; CT1.1
UniProt Entry Name
MAGA1_HUMAN
NCBI Protein Information
melanoma-associated antigen 1; MAGE-1 antigen; antigen MZ2-E; cancer/testis antigen 1.1; cancer/testis antigen family 1, member 1; melanoma antigen MAGE-1; melanoma antigen family A 1; melanoma antigen family A, 1 (directs expression of antigen MZ2-E); me

UniProt Comments for MAGE-1

MAGE-A1: a tumor antigen expressed in a variety of tumor cells and in the testis. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Protein type: Cell surface

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: cytoplasm; plasma membrane; nucleus

Molecular Function: protein binding; histone deacetylase binding

Biological Process: transcription, DNA-dependent; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MAGE-1 antibody

 Reference Product  PubMed Publications
 HLA-A antibody  >42 publications with MAGE-1 and HLA-A
 GAGE2A antibody  >11 publications with MAGE-1 and GAGE2A
 MAGEA12 antibody  >6 publications with MAGE-1 and MAGEA12
 CTAG2 antibody  >3 publications with MAGE-1 and CTAG2
 DDX43 antibody  >1 publications with MAGE-1 and DDX43

Pathways associated with anti-MAGE-1 antibody

 Products by Pathway  Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram

Diseases associated with anti-MAGE-1 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >89 publications with MAGE-1 and Carcinoma
 Adenocarcinoma Antibodies  >46 publications with MAGE-1 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >29 publications with MAGE-1 and Carcinoma, Hepatocellular
 Head and Neck Neoplasms Antibodies  >25 publications with MAGE-1 and Head and Neck Neoplasms
 Lung Neoplasms Antibodies  >23 publications with MAGE-1 and Lung Neoplasms
 Carcinoma, Squamous Cell Antibodies  >21 publications with MAGE-1 and Carcinoma, Squamous Cell
 Skin Neoplasms Antibodies  >17 publications with MAGE-1 and Skin Neoplasms
 Stomach Neoplasms Antibodies  >17 publications with MAGE-1 and Stomach Neoplasms
 Sarcoma Antibodies  >17 publications with MAGE-1 and Sarcoma
 Neoplasms, Experimental Antibodies  >15 publications with MAGE-1 and Neoplasms, Experimental

Organs/Tissues associated with anti-MAGE-1 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >83 publications with MAGE-1 and Testis
 Lung Antibodies  >28 publications with MAGE-1 and Lung
 Skin Antibodies  >19 publications with MAGE-1 and Skin
 Bone Antibodies  >11 publications with MAGE-1 and Bone
 Ovary Antibodies  >3 publications with MAGE-1 and Ovary
 Connective Tissue Antibodies  >1 publications with MAGE-1 and Connective Tissue
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